Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integration

Bazyan, A. S.; Getsova, V. M.; Orlova, N. V.

doi:10.1016/s0306-4522(00)00183-4

Cited by 13 publications

(6 citation statements)

References 57 publications

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“…Also, the DA system is involved in the modification of various epileptiform states (Al Tajir & Starr, 1991;Ogren & Pakh, 1993;Amabeoku & Chikuni, 1994). The results shown in our work (Bazyan et al, 2000b), allow us to suggest that in the process of learning the receptors of the DA system and GABA A receptors of the brain interact and become modified and integrated, thus forming a learning-depended emotional state. We suggest that this integration is accomplished by the mechanism of intracellular integration of glutamate, GABA A and DA receptors by means of transduction signal.…”

Section: Interaction Of Ptz-induced Seizures With Learning Memory Ansupporting

confidence: 65%

“…At the same time, anxiogenic effects of PTZ are also known [Biggio et al, 1990;Venault et al, 1992;Simon et al, 1993]. It was shown [Bazyan et al, 2000b] [Bazyan et al, 2001a] was designed to study the modification of seizures by learning; the facilitation of amnesic memory trace retrieval by a pharmacological reminder of the emotional state which accompanied the learning processes. Passive avoidance conditioning was performed (Bazyan et al, 2001a).…”

Section: Interaction Of Ptz-induced Seizures With Learning Memory Anmentioning

confidence: 99%

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Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain

Bazyan¹

2011

Underlying Mechanisms of Epilepsy

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Section: Interaction Of Ptz-induced Seizures With Learning Memory Ansupporting

confidence: 65%

Section: Interaction Of Ptz-induced Seizures With Learning Memory Anmentioning

confidence: 99%

Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain

Bazyan¹

2011

Underlying Mechanisms of Epilepsy

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“…It was suggested that (Maas and Leckman, 1983;Uzbekov et al, 1988;Uzbekov et al, 1991) and that the dopaminergic system plays an important role in the central mechanisms of motor function and its activation is responsible for the locomotor hyperactivity (Bazyan et al, 2000;Kobayashi et al, 1997;Maj et al, 1997;Tucci et al, 1994). These results emphasize the important role of dopamine and noradrenaline in the regulation of motor activity and different behavioural reactions.…”

Section: Discussionmentioning

confidence: 98%

Changes in urinary monoamine excretion in hyperkinetic children

Узбеков¹,

Misionzhnik²

2003

Human Psychopharmacology

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The pathogenetic mechanisms of hyperkinetic syndrome are not clear and need further investigation. The aim of the study was to find certain features of monoamine metabolism that are characteristic of children with hyperkinetic syndrome (HKS) with special regard to different degrees of severity (i.e. mild HKS and severe HKS ). The levels of L-dopa, dopamine, noradrenaline, adrenaline, homovanillic, vanillylmandelic and 5-hydroxyindoleacetic acids were measured in daily urine of children (7-11 years old) with mild and severe HKS using fluorimetric and chromatographic methods. Severe HKS was characterized by a significant increase of L-dopa (by 186%), dopamine (by 201%) and adrenaline (by 160%) excretion but an unchanged excretion of noradrenaline compared with those with mild HKS. The study revealed principle differences in monoamine metabolism between the mild and severe forms of HKS which may be of importance in deciding different pharmacotherapeutic approaches to use in patients with HKS of differing severity.

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“…At the same time, anxiogenic effects of PTZ are also known [Biggio et al, 1990;Venault et al, 1992;Simon et al, 1993]. It was shown [Bazyan et al, 2000b] that haloperidol-induced catalepsy, which produces a long-term modification of DA receptors, is modified by defensive conditioning. So, the next investigation [Bazyan et al, 2001a] was designed to study the modification of seizures by learning; the facilitation of amnesic memory trace retrieval by a pharmacological reminder of the emotional state which accompanied the learning processes.…”

Section: Interaction Of Ptz-induced Seizures With Learning Memory and Emotional Statementioning

confidence: 99%

Underlying Mechanisms of Epilepsy

Kaneez¹

2011

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She has been teaching Neurosciences, General and Medical Sciences, and other Biological Sciences for the last thirty years to Science, Medical and Paramedical graduates and post-graduates in Australia, USA, UAE, Bahrain, Pakistan and Brunei Darussalam. She has also been involved in developing, writing, interacting and getting General and Medical Research grants around the world. She completed her first post doc in Prof White's lab at Allegheny University of Health Sciences, Philadelphia, USA. There she was involved in mutating serotonin type 3 channel lumen and identifying the amino acids responsible for ionic selectivity of the channel by using site directed mutagenesis in conjunction with patch clamping. During her PhD she was the first to exhibit the presence of glycine receptor channels in postnatal hippocampal neurons. She has experience in multiple techniques including: Patch Clamp, Tissue culture, Single Cell RT PCR, Proteomics and Bioinformatics. She is a member of 14 learned societies including her role as regional representative of Women in World Neurosciences (WWN) and coordinator of the Neuroscience Program Network, IBRO (NPN). She has achieved many awards and scholarships, is the author of 20 full refereed papers published in International Tier 1 and 2 journals and 66 refereed conference and short communications. She is the editor of 3 books and 4 journals and has contributed a number of book chapters and reviews.

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Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integration

Cited by 13 publications

References 57 publications

Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain

Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain

Changes in urinary monoamine excretion in hyperkinetic children

Underlying Mechanisms of Epilepsy

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