Haloperidol blood levels and clinical outcome: a meta-analysis of studies relevant to testing the therapeutic window hypothesis

Oliveira, Ivanka Rosada de; Sena, Eduardo Pondé de; Pereira, Érika Sales Joviano; Miranda, AA; Oliveira, N. F. de; Ribeiro, Marcos Borges; Castro-e-Silva, Emilio De; Dardennes, Roland; Samuel-Lajeunesse, B; Marcílio, C.

doi:10.1111/j.1365-2710.1996.tb01143.x

Cited by 27 publications

(10 citation statements)

References 29 publications

(27 reference statements)

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“…According to a systematic review carried out by our group involving trials performed over the past 30 years on the blood levels of this drug, the efficacy of haloperidol was 55% in schizophrenia and schizoaffective disorder; therefore, the failure rate was only 45% 30 . Nevertheless, following the exclusion of patients with blood levels outside the suggested therapeutic window (8-30 ng/ml), efficacy increased to 62%, i.e.…”

Section: Discussionmentioning

confidence: 99%

Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics

Oliveira

Nunes

Coutinho

et al. 2009

Rev. Bras. Psiquiatr.

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Section: Discussionmentioning

confidence: 99%

Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics

Oliveira

Nunes

Coutinho

et al. 2009

Rev. Bras. Psiquiatr.

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“…A range of clozapine and haloperidol doses encompassing previously reported plasma therapeutic ranges of 350–420 ng/mL for clozapine (Mauri et al, 2007) and 4–26 ng/mL for haloperidol (de Oliveira et al, 1996) were used to treat cultured lymphocytes. Stock solutions of clozapine and haloperidol were prepared in methanol.…”

Section: Methodsmentioning

confidence: 99%

Telomerase levels in schizophrenia: A preliminary study

Porton

DeLisi

Bertisch

et al. 2008

Schizophrenia Research

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We previously demonstrated that telomere length was markedly reduced in peripheral blood lymphocytes from individuals with schizophrenia. Since reduced telomere length can be caused by decreased telomerase activity, we quantitated basal telomerase activity in peripheral blood lymphocytes derived from individuals with schizophrenia (n=53), unaffected relatives (n=31) and unrelated controls (n=59). Telomerase activity varied greatly among individuals, suggesting that this enzymatic activity is affected by various factors. We observed a nominally significant decrease in telomerase activity among individuals with schizophrenia compared to unaffected individuals (unaffected relatives and unrelated controls). Further studies are needed to investigate the role of telomerase in schizophrenia.

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“…High-quality studies appeared to show positive effect and low-quality were equivalent. Identified trend of effectiveness of myofeedback not conclusive owing to methodological limitations de Oliveira, 1996 246 Quantitative All studies bar one scored >0.6. When the lower-quality study was excluded from the meta-analysis the results Excluded lower quality studies did not change (no data presented) Detsky, 1987 309 Quantitative Quality scores were negatively correlated with the differences in complication (correlation coefficient -0.56, Correlation analysis p = 0.13) and fatality rates (coefficient -0.51, p = 0.031) between groups, i.e.…”

Section: Quantitativementioning

confidence: 99%

Evaluating non-randomised intervention studies

Deeks¹,

Dinnes²,

D’Amico³

et al. 2003

Health Technol Assess

2,146

1,464

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Haloperidol blood levels and clinical outcome: a meta-analysis of studies relevant to testing the therapeutic window hypothesis

Cited by 27 publications

References 29 publications

Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics

Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics

Telomerase levels in schizophrenia: A preliminary study

Evaluating non-randomised intervention studies

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