Haloperidol and cognitive shifting

Berger, Hans; Hoof, J.J.M. van; Spaendonck, K.P.M. van; Horstink, M.W.I.M.; Bercken, J.H.L. van den; Jaspers, R.M.A.; Cools, A.R.

doi:10.1016/0028-3932(89)90109-7

Cited by 46 publications

(18 citation statements)

References 44 publications

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“…Some aspects of performance indicated that neuroleptic-treated subjects were able to acquire a problem solving routine : cognitive times per move and CTV index progressively decreased while reliability indexes increased throughout the trials, reaching a level in the third block that was not signiÞcantly di¤erent from the placebo-group. It has been reported in haloperidol-treated patients with an idiopathic spasmodic torticollis (Berger et al 1989). These results provided strong evidence that knowledge compilation was not impaired by haloperidol and amisulpride.…”

Section: Discussionsupporting

confidence: 73%

Effects of haloperidol and amisulpride on motor and cognitive skill learning in healthy volunteers

et al. 1997

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The effects of a typical neuroleptic, haloperidol (1 and 2 mg orally), of an atypical neuroleptic, amisulpride (50 and 100 mg) and of a placebo on motor and cognitive skill learning were assessed in 60 healthy volunteers using repeated testing on the Tower of Toronto puzzle. Subjects were asked to solve three blocks of eight trials and, at distance from drug administration, a fourth block. The puzzle was connected to a computer in order to obtain a precise timing of individual moves. Two components of cognitive skill learning were assessed, the ability to learn to solve the puzzle and the acquisition of a problem-solving routine. Subjective feelings of effort and automatisation of the task were assessed using a questionnaire. Like placebo-treated subjects, neuroleptic-treated subjects were able to acquire a motor skill, to learn to solve the puzzle and to acquire a routine. However, haloperidol 2 mg-treated subjects needed significantly more moves to solve the puzzle in blocks 3 and 4, some of them having routinised a non-optimal solution. A significant cognitive slowing was observed in the haloperidol 1 mg group in block 4. The performance pattern and verbal reports suggested that haloperidol impaired the higher cognitive functions such as the ability to shift from one strategy to another and/or to assess one's performance accurately, possibly leading to the development of compensatory strategies. The only deleterious amisulpride effect was a cognitive slowing in block 4, which was observed in the lower dose group.

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Section: Discussionsupporting

confidence: 73%

Effects of haloperidol and amisulpride on motor and cognitive skill learning in healthy volunteers

et al. 1997

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“…In contrast, the selective activation of coupling within limbic circuits that occurs upon withdrawal from repeated amphetamine administration (Onn and Grace 2000) may also lead to a type of "cognitive" stereotypy, such as the perseverative drug-seeking behavior demonstrated as a consequence of drug abuse. Within this context, the present findings on the actions of gap junction inactivators may have relevance for diseases such as obsessive-compulsive disorder, drug abuse, and schizophrenia, or other disorders that are associated with disruption of cognitive and/or motor sequencing (Berger et al 1989;Cools et al 2001;Hymas et al 1991;Ridley 1994;Sullivan et al 2001).…”

Section: The Role Of Gap Junctions and Dopamine In Signal Flow Acrossmentioning

confidence: 90%

A Role for Electrotonic Coupling in the Striatum in the Expression of Dopamine Receptor-mediated Stereotypies,

Moore

Grace

2002

Neuropsychopharmacology

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Stimulation of dopamine (DA) receptors in the striatum evokes a number of alterations in motor behavior in rats, as well as causing several alterations in cellular physiology, including changes in membrane potential, cell excitability, afferent drive, and electrotonic coupling. One cellular property that is potently modulated by DA stimulation is electrotonic coupling, a process shown to subserve motor pattern generation. To examine whether electrotonic coupling plays a role in mediating a specific set of DA receptor-mediated motor behaviors, we tested the effects of two inhibitors of gap junction conductance, carbenoxolone (CARB) and anandamide (AEA), on apomorphine (APO)-induced motor responses. We then used intra-striatal infusions of CARB to determine the role of electrotonic coupling specifically in the ventral striatum in the expression of i.p.) significantly increased motor activity (a composite score) and the frequencies of oral and sniffing stereotypies. APO also disrupted grooming initiation and completion. APO-induced oral stereotypies were selectively blocked by systemic administration of CARB (7.0, 35.0 mg/kg Adaptive behaviors, both learned and spontaneous, consist of sequences of "micro" movements executed by closely-related muscle groups. There is evidence that the initiation and execution of individual movements, such as oral movements involved in feeding, as well as the linking of these movements into a behavioral sequence, depend upon neuronal networks within the Beninger et al. 1991;Braun and Chase 1986;Byrnes et al. 1994;Delfs and Kelley 1990). Thus, in the context of behavioral sequencing, the simple 'repetitive' stereotypy (Berridge and Aldridge 2000a) produced by D2 receptor over-stimulation in the striatum (Delfs and Kelley 1990) can be seen as the inability to release one 'simple' behavior in order to allow initiation of the next simple behavior in a normal, adaptive sequence (Pedro et al. 1994;Szechtman et al. 1999). One means by which neuronal networks may interact within the striatum is via communication among clusters of functionally related striatal neurons. Such a network interaction may be mediated via gap junctions. It is well-established that electrotonic transmission between developing neurons is important in the formation and stabilization of functional networks (Bannerman et al. 2000;Peinado et al. 1993;Roerig and Feller 2000). However, there is also evidence that in the adult brain, electrotonic coupling directly mediates forms of neuronal network activity (Bou-Flores and Berger 2001;Jefferys 1995;Perez Velazquez and Carlen 2000) which, in turn, contribute to rhythmic behavioral patterning (Bou-Flores and Berger 2001;Rothwell 1998). Thus, it is likely that motor patterning may involve activity within neuronal networks coordinated via gap junctions. In the striatum, cells express connexins, the protein building blocks of gap junctions (Belluardo et al. 2000;Bennett et al. 1999). Striatal neurons also exhibit dye coupling, the transfer of dye molecules between neurons thro...

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“…Many of these have involved putative "frontal lobe" tests but, in fact, none of these is likely to be selective for frontal lobe function (22). Moreover, those who have looked for an effect on the shifting of attention have reported opposite findings (23,24).…”

Section: Need For Volunteer Studiesmentioning

confidence: 96%

Psychomotor impairment and cognitive disturbances induced by neuroleptics

King

1994

Acta Psychiatr Scand

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Acra Psj~chintr Sraiid I YY? ' 89 lciippl 380): 53-58 Priiil~d in Br(yiuin -rill ri,qlif.r resevied Psychomotor impairment and cognitive disturbances induced by neuroleptics King DJ. Psychomotor impairment and cognitive disturbances induced by neuroleptics. Acta Psychiatr Scand 1994: 89 (suppl 380): 53-58. 0 Munksgaard 1994.Reviews of the literature have failed to demonstrate any consistent effects of typical or atypical neuroleptics on psychomotor or cognitive function in schizophrenic patients. Better methods and study designs are required, and healthy volunteer studies are necessary to control for variables due to schizophrenic psychopathology. Eye movements are a sensitive, reliable and relatively pure measure of attention and arousal. Two volunteer studies of the effects of single doses of haloperidol (2, 4 and 6 mg), chlorpromazine ( 5 0 mg) and remoxipride (100 and 150 mg) on saccadic and smooth pursuit eye movements are described. All drugs impaired both eye movement measures, but the doses used were not clinically equivalent. No available test is yet able to distinguish between benzodiazepines and neuroleptics.

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Haloperidol and cognitive shifting

Cited by 46 publications

References 44 publications

Effects of haloperidol and amisulpride on motor and cognitive skill learning in healthy volunteers

Effects of haloperidol and amisulpride on motor and cognitive skill learning in healthy volunteers

A Role for Electrotonic Coupling in the Striatum in the Expression of Dopamine Receptor-mediated Stereotypies,

Psychomotor impairment and cognitive disturbances induced by neuroleptics

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