Haloperidol and amisulpride cause different side-effects and negative symptoms in healthy volunteers

Louwerens, Jw; Ramaekers, J.G.; Bie, Anaïs De; Millius, H.; Muntjewerff, N.; Rosenzweig, P.; O’Hanlon, John

doi:10.1016/s0006-3223(97)87847-x

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“…Amisulpride belongs to the atypical neuroleptics group. So far, nausea, insomnia or tiredness, gastrointestinal symptoms, and somewhat more seldom, extrapyramidal and endocrine symptoms have come to be known as fairly common adverse effects of this drug, whereas cardiovascular adverse effects appear to be rare [2,6,12].…”

Section: Introductionmentioning

confidence: 99%

Asymptomatic Bradycardia Associated with Amisulpride

Gil¹,

Grohmann²,

Rüther³

2001

Pharmacopsychiatry

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Well-known adverse effects of amisulpride include nausea, insomnia or tiredness, gastrointestinal, extrapyramidal and endocrine symptoms. Cardiac disorders, however, appear to be an extremely rare complication of the drug. Only a few case reports on this complication have been published so far, which deal with QT prolongation, hypotension, hypertension and palpitations. Bradycardia has not yet been mentioned. Here, we will report on a case of asymptomatic bradycardia that developed subsequent to therapeutic doses of amisulpride in a 25-year-old male patient with chronic paranoid-hallucinatory schizophrenia. The patient had been rehospitalized for an acute exacerbation of the psychosis. When the patient failed to respond at the beginning of hospitalization, the treatment was changed from clozapine to amisulpride. After a complete switchover to amisulpride, the patient's ECG showed sinus bradycardia and QT prolongation. When the daily dose of amisulpride was reduced from 800 mg/d to 600 mg/d, the patient's ECG quickly normalized (including blood pressure and pulse rate) within a few days. The patient did not report any cardiovascular-related complaints. Since the cardiovascular-specific diagnostics did not yield any indicative results, bradycardia may be a rare complication of amisulpride treatment.

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Section: Introductionmentioning

confidence: 99%