Halogenation of Imidazo[4,5‐b]pyridin‐2‐one Derivatives

Abstract

Fused pyridine derivatives R 0450 Halogenation of Imidazo[4,5-b]pyridin-2-one Derivatives -[with a view to obtaining pharmacologically interesting products]. -(YUTILOV, Y. M.; LOPATINSKAYA, K. Y.; SMOLYAR, N. N.; GRES'KO, S. V.; Russ. J. Org. Chem. 41 (2005) 4, 575-579; Litvinenko Inst. Phys. Org. Coal Chem., Natl. Acad. Sci. Ukr., Donetsk 340114, Ukraine; Eng.) -R. Langenstrassen 42-166

6-Bromo-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

“…The synthesis of 1,3-dimethyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one involves several steps (Yutilov et al, 1998(Yutilov et al, , 2005). The 6-bromo derivative (Scheme I) is conveniently synthesized by the direct reaction of 6-bromo-1,3-dihydroimidazo[4,5-b]pyridin-2-one with methyl iodide.…”