Halogenated non-innocent vanadium(<scp>v</scp>) Schiff base complexes: chemical and anti-proliferative properties

Haase, Allison A.; Markham, Skyler A.; Murakami, Heide A.; Hagan, John; Kostenkova, Kateryna; Koehn, Jordan T.; Uslan, Canan; Beuning, Cheryle N.; Brandenburg, Lee; Zadrozny, Joseph M.; Levina, Aviva; Lay, Peter A.; Crans, Debbie C.

doi:10.1039/d4nj01223b

New J. Chem.

2024

DOI: 10.1039/d4nj01223b

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Halogenated non-innocent vanadium(v) Schiff base complexes: chemical and anti-proliferative properties

Allison A. Haase,

Skyler A. Markham,

Heide A. Murakami

et al.

Abstract: A series of non-innocent halogen substituted Schiff base vanadium catecholate added different electron donating and withdrawing substituents on the catecholate to investigate the electronic effects on the properties of this...

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Exploring the Potential of N‐Benzylidenebenzohydrazide Derivatives as Antidiabetic and Antioxidant Agents: Design, Synthesis, Spectroscopic, Crystal Structure, DFT and Molecular Docking Study

Waziri,

Yusuf,

Kelani

et al. 2024

ChemistrySelect

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Hydrazone‐type Schiff bases have been widely explored owing to their therapeutic properties. These compounds are known to have antibacterial, antifungal, anticancer, and antioxidant properties, among others. In the present study, six hydrazone‐based Schiff bases (BB1–BB6) were synthesized by the reaction between derivatives of benzaldehyde and benzo hydrazide in methanolic medium in the presence of catalytic amount of formic acid. The synthesized compounds were characterized using various spectroscopic techniques such as NMR (1H, 13C, COSY, DEPT, HSQC, HMBC, and NOESY), FTIR, UV‐Vis, elemental (CHN) analysis, and high‐resolution mass spectroscopy. In addition, single crystal structures of BB2, BB4, and BB6 were obtained. In vitro antidiabetic and antioxidant potential of the compounds was evaluated on glucosidase, amylase, NO, FRAP, and DPPH assays, respectively. In all the assays, compounds BB6, BB4, and BB2 showed higher activity than the others. To further explore the chemical reactivity properties and their mechanism of action against the tested assays, DFT and molecular docking study were performed, and the results obtained reinforce the experimental study data.

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Exploring the Potential of N‐Benzylidenebenzohydrazide Derivatives as Antidiabetic and Antioxidant Agents: Design, Synthesis, Spectroscopic, Crystal Structure, DFT and Molecular Docking Study

Waziri,

Yusuf,

Kelani

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

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Halogenated non-innocent vanadium(v) Schiff base complexes: chemical and anti-proliferative properties

Abstract: A series of non-innocent halogen substituted Schiff base vanadium catecholate added different electron donating and withdrawing substituents on the catecholate to investigate the electronic effects on the properties of this...

Cited by 1 publication

References 69 publications

Exploring the Potential of N‐Benzylidenebenzohydrazide Derivatives as Antidiabetic and Antioxidant Agents: Design, Synthesis, Spectroscopic, Crystal Structure, DFT and Molecular Docking Study

Exploring the Potential of N‐Benzylidenebenzohydrazide Derivatives as Antidiabetic and Antioxidant Agents: Design, Synthesis, Spectroscopic, Crystal Structure, DFT and Molecular Docking Study

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