“…As a result of these combined advantages, increasingly sophisticated and potent XB sensors have been developed, in particular in the last z5 years. This includes, for example, systems capable of anion sensing in increasingly competitive media, including pure water, 101,162,166 as well as continuous, real-time sensing systems. 71,72,131,171,172 These signicant advances in a comparably short amount of time attest to the enormous future potential of sigma-hole based sensors for real-life relevant applications and provide an excellent foundation for a broad range of research activities in sensor development and related applications as well as fundamental host-guest studies.…”