Halofantrine and Pruritus

Hallwood, P M; Horton, Ralph; O'sullivan, K.; Parr, S N

doi:10.1016/s0140-6736(89)90582-5

Cited by 6 publications

(1 citation statement)

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“…As with other antimalarial drugs, allergic side-effects can occur after administration of halofantrine. Pruritus is commonly observed, but its incidence with halofantrine, estim ated at 2%± 13%, is lower than with chloroquine (Hallwood et al, 1989;Sowunm i et al, 1989). More recently, anaphylactic shock following a second treatment with halofantrine has been reported (Fourcade et al, 1996).…”

Section: Oth Er Com Plicationsmentioning

confidence: 99%

Is halofantrine still advisable in malaria attacks

Touze

Fourcade

Peyron

et al. 1997

Annals of Tropical Medicine And Parasitology

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Halofantrine is an antimalarial drug which is widely prescribed for the treatment of infections with chloroquine-resistant strains of Plasmodium falciparum. Chemically, it is a phenanthrene methanol, belonging to the aryl-amino-alcohol family. It has recently been recognized that this drug may induce rare but serious, cardiotoxic effects, including lengthening of the QTc interval, 'torsade de pointes' and induction of late ventricular potentials. These events are thought to be related to a quinidine-like action of the drug. In addition, severe haemolytic accidents have been reported, mimicking blackwater fever and indicating an immunological process. As a result of these side-effects, new guidelines for prescription and more cautious use of halofantrine, particularly as a stand-by treatment for febrile access among travellers, are required.

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Section: Oth Er Com Plicationsmentioning

confidence: 99%