Haloarchaea: A Promising Biosource for Carotenoid Production

Rodrigo-Baños, Montserrat; Montero, Zaida; Torregrosa-Crespo, Javier; Garbayo, Inés; Vı́lchez, C.; Martínez‐Espinosa, Rosa María

doi:10.1007/978-981-15-7360-6_13

Cited by 6 publications

(9 citation statements)

References 61 publications

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“…Archaea, especially Haloarchaea, mostly synthesize an uncommon C 50 carotenoid called bacterioruberin (BR) and its intermediates: bisanhydrobacterioruberin (BABR), monoanhydrobacterioruberin (MABR), and 2-isopentenyl-3,4-dehydrorhodopin (IDR) [ 75 , 76 , 77 , 78 ]. These 50-carbon carotenoids function to increase membrane rigidity [ 79 ] and provide protection against UV light [ 80 ].…”

Section: Archaea Pigments: Bacteriorhodopsin and Carotenoidsmentioning

confidence: 99%

Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential

et al. 2022

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For more than 40 years, marine microorganisms have raised great interest because of their major ecological function and their numerous applications for biotechnology and pharmacology. Particularly, Archaea represent a resource of great potential for the identification of new metabolites because of their adaptation to extreme environmental conditions and their original metabolic pathways, allowing the synthesis of unique biomolecules. Studies on archaeal carotenoids are still relatively scarce and only a few works have focused on their industrial scale production and their biotechnological and pharmacological properties, while the societal demand for these bioactive pigments is growing. This article aims to provide a comprehensive review of the current knowledge on carotenoid metabolism in Archaea and the potential applications of these pigments in biotechnology and medicine. After reviewing the ecology and classification of these microorganisms, as well as their unique cellular and biochemical characteristics, this paper highlights the most recent data concerning carotenoid metabolism in Archaea, the biological properties of these pigments, and biotechnological considerations for their production at industrial scale.

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Section: Archaea Pigments: Bacteriorhodopsin and Carotenoidsmentioning

confidence: 99%

Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential

et al. 2022

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“…It acts as cellular membrane reinforcement since it increases membrane rigidity and decreases water permeability. It also protects haloarchaeal cells from DNA damage resulting from radiography, ultraviolet radiation, and hydrogen peroxide exposure (Rodrigo-Baños et al 2021).…”

Section: Carotenoid Profile Of Haloarcula Sp Bt9mentioning

confidence: 99%

“…Moreover, extraction process may be simpler and faster since the exposure of the cells to low salt concentrations induces membrane lysis, and consequently avoids cost investments in terms of energy required to enable efficient cell breaking. Also, C 50 carotenoids biosynthesis can be easily enhanced by modifying several cultivation aspects (Giani et al 2019;Rodrigo-Baños et al 2021).…”

Section: Introductionmentioning

confidence: 99%

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Characterization and biological activities of carotenoids produced by three haloarchaeal strains isolated from Algerian salt lakes

Sahli¹,

Gomri²,

Esclapez

et al. 2021

Arch Microbiol

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Halophilic archaea represent a promising natural source of carotenoids. However, little information is available about these archaeal metabolites and their biological effects. In the present work, carotenoids of strains Haloferax sp. ME16, Halogeometricum sp. ME3 and Haloarcula sp. BT9, isolated from Algerian salt lakes, were produced, extracted and identified by high-performance liquid chromatography-diode array detector and liquid chromatography-mass spectrometry. Analytical results revealed a variation in the composition depending on the strain with a predominance of bacterioruberin. The evaluation of antioxidant capacity using ABTS [(2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] and DPPH (2,2-diphenyl-1-picrylhydrazyl) assays showed that these extracts have a strong antioxidant potential, in particular those of Haloferax sp. ME16 which displayed antioxidant power significantly higher than that of ascorbic acid used as standard. Antibacterial activity of carotenoid extracts against four human-pathogenic strains and four fish-pathogenic strains was evaluated by agar disk diffusion method. The results showed a good antibacterial activity. These findings suggest that the C 50 carotenoids from the studied strains offer promising prospects for biotechnological applications.

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“…Haloarchaea synthesize mainly a rare C 50 carotenoid called bacterioruberin (BR) and its derivatives: bisanhydrobacterioruberin (BABR), monoanhydrobacterioruberin (MABR), and 2-isopentenyl-3,4-dehydrorhodopin (IDR) [171][172][173][174]. Other derivatives have been detected at lower concentrations, such as haloxanthin and 3,4-dehydromonoanhydrobacterioruberin; and depending on the haloarchaeal species, such as 3,4-epoxymonoanhydrobacterioruberin, which has only been described in Haloferax volcanii carotenoid extracts [175].…”

Section: Rare Carotenoids From Halophilic Microorganisms: the Future Of Biomedicine? Bacterioruberin From Haloarchaeamentioning

confidence: 99%

Halophilic Carotenoids and Breast Cancer: From Salt Marshes to Biomedicine

Giani

Montoyo-Pujol²,

Peiró³

et al. 2021

Marine Drugs

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Breast cancer is the leading cause of death among women worldwide. Over the years, oxidative stress has been linked to the onset and progression of cancer. In addition to the classical histological classification, breast carcinomas are classified into phenotypes according to hormone receptors (estrogen receptor—RE—/progesterone receptor—PR) and growth factor receptor (human epidermal growth factor receptor—HER2) expression. Luminal tumors (ER/PR-positive/HER2-negative) are present in older patients with a better outcome. However, patients with HER2-positive or triple-negative breast cancer (TNBC) (ER/PR/HER2-negative) subtypes still represent highly aggressive behavior, metastasis, poor prognosis, and drug resistance. Therefore, new alternative therapies have become an urgent clinical need. In recent years, anticancer agents based on natural products have been receiving huge interest. In particular, carotenoids are natural compounds present in fruits and vegetables, but algae, bacteria, and archaea also produce them. The antioxidant properties of carotenoids have been studied during the last years due to their potential in preventing and treating multiple diseases, including cancer. Although the effect of carotenoids on breast cancer during in vitro and in vivo studies is promising, clinical trials are still inconclusive. The haloarchaeal carotenoid bacterioruberin holds great promise to the future of biomedicine due to its particular structure, and antioxidant activity. However, much work remains to be performed to draw firm conclusions. This review summarizes the current knowledge on pre-clinical and clinical analysis on the use of carotenoids as chemopreventive and chemotherapeutic agents in breast cancer, highlighting the most recent results regarding the use of bacterioruberin from haloarchaea.

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Haloarchaea: A Promising Biosource for Carotenoid Production

Cited by 6 publications

References 61 publications

Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential

Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential

Characterization and biological activities of carotenoids produced by three haloarchaeal strains isolated from Algerian salt lakes

Halophilic Carotenoids and Breast Cancer: From Salt Marshes to Biomedicine

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