Hallucinations: Synchronisation of thalamocortical γ oscillations underconstrained by sensory input

Behrendt, Ralf-Peter

doi:10.1016/s1053-8100(03)00017-5

Cited by 60 publications

(49 citation statements)

References 132 publications

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“…The formation of the γ rhythm is considered to be related to the development of resonance states in neuronal networks; this provides the extensive spreading of γ oscillations within the cerebral cortex [2]. The γ-frequency oscillations and their synchronization are supposed to contribute to the formation and development of interconnected neuronal ensembles and mechanisms playing important roles in learning, memory, and behavior [22]. Functional rearrangement of cell groups (in the case of transition from a simple state to a more complex state) is a neurophysiological mechanism responsible for generation of the γ rhythm, and this process is realized with participation of the mesencephalic reticular formation and cholinergic reticulo-cortical pathways [23].…”

Section: Discussionmentioning

confidence: 99%

Interrelations between Peculiarities of the Motivational Sphere of a Personality and Characteristics of the Current EEG

Konareva

2009

Neurophysiology

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In a group of 70 adult subjects of both sexes, we estimated the levels of the need for achievement and its motivation (interpreted as generalized characteristics of the state of the motivational sphere of a personality and diagnosed using questionnaires of Orlov and Mehrabian) and examined the correlations of these estimates with spectral powers (SPs) of the frequency components (rhythms) of the current background EEG (С3 and С4 leads according to the 10-20 system). Despite the fact that naturally high interindividual variability exists, high estimates of the need for achievement correlated with medium values of the SPs of most EEG frequency components (δ, θ, α, and β 1 rhythms), low SPs of the β 2 and γ rhythms, and higher values of the coefficient of reactivity (CR) of the α rhythm. A high level of the need for achievement corresponded to higher SPs of the θ and γ rhythms and high CR of the α rhythm, a medium SP of this EEG component, and lower SPs of the δ and β rhythms. The coefficient of interhemisphere asymmetry of the α rhythm was the highest at low values of the studied psychological indices. Interrelations that we found in our study can be explained as follows: both the characteristics of the need for achievement and motivation typical of a certain personality and the amplitude parameters of the EEG rhythms observed in this individual depend significantly on genetically determined factors (in particular, on neurochemical ones). These peculiarities of neurodynamic constitution of the individual are, to a considerable extent, due to the specificity of organization and functioning of a few neurotransmitter (aminergic, in particular) and neurohumoral systems.

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Section: Discussionmentioning

confidence: 99%

Interrelations between Peculiarities of the Motivational Sphere of a Personality and Characteristics of the Current EEG

Konareva

2009

Neurophysiology

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“…Since then several other rhythms have been recorded in association with the wake -sleep cycle, with cognitive tasks and/or with clinical disorders (e.g., Refs. [18,32,82,135,272]). Studies by Adrian and Matthews [1] and by Bremer [25] led electrophysiologists to conclude that rhythms recorded on the brain surface were generated by deep structures, including the thalamus [6,117,171,173,209].…”

Section: Thalamocortical Oscillationsmentioning

confidence: 99%

The thalamic reticular nucleus: structure, function and concept

Pinault

2004

Brain Research Reviews

556

480

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“…Since sensory and cognitive-related GFO are altered in schizophrenia, one may predict that baseline GFO could somehow modulate them (Hakami et al, 2009). Increased baseline GFO have been recorded in patients during psychotic episodes, including somatic and visual hallucinations (Baldeweg et al, 1998;Becker et al, 2009;Behrendt, 2003;Ffytche, 2008;Spencer et al, 2004), and in early psychosis (Bartha et al, 1997;Theberge et al, 2002). Increases in the amount of baseline GFO are a significant source of excessive network noise in the brain (Baldeweg et al, 1998; Gandal et al, 2011;Hakami et al, 2009;Rolls et al, 2008).…”

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confidence: 99%

Opposite effects of ketamine and deep brain stimulation on rat thalamocortical information processing

Kulikova

Tolmacheva

Anderson

et al. 2012

Eur J of Neuroscience

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Opposite effects of ketamine and deep brain stimulation on rat thalamocortical information processing Sofya P Kulikova (1,2)*, Elena A Tolmacheva (1,2)**, Paul Anderson (1,2,3), Julien Gaudias (1,2)***, Brendan E Adams (1,2)****, Thomas Zheng (1,2,3), and Didier Pinault (1,2)(1) INSERM U666, physiopathologie et psychopathologie cognitive de la schizophrénie, Strasbourg, France. Abstract:Sensory and cognitive deficits are common in schizophrenia. They are associated with abnormal brain rhythms, including disturbances in γ frequency (30-80 Hz) oscillations (GFO) in cortex-related networks. However, the underlying anatomo-functional mechanisms remain elusive. Clinical and experimental evidence suggest that these deficits result from a hyporegulation of glutamate N-Methyl d-Aspartate receptors (NMDAr). Here we modeled these deficits in rats with ketamine, a non-competitive NMDAr antagonist and a translational psychotomimetic substance at subanesthetic doses. We tested the hypothesis that ketamine-induced sensory deficits involve an impairment of the ability of the thalamocortical (TC) system to discriminate the relevant information from the baseline activity. Furthermore we wanted to assess whether ketamine disrupts synaptic plasticity in TC systems. We conducted multisite network recordings in the rat somatosensory TC system, natural stimulation of the vibrissae and high-frequency electrical stimulation (HFS) of the thalamus.A single systemic injection of ketamine increased the amount of baseline GFO, reduced the amplitude of the sensory-evoked TC response and decreased the power of the sensoryevoked GFO. Furthermore, cortical application of ketamine elicited local and distant increases in baseline GFO. The ketamine effects were transient. Unexpectedly, HFS of the TC pathway had opposite actions. In conclusion, ketamine and thalamic HFS have opposite effects on the ability of the somatosensory TC system to discriminate the sensory-evoked response from the baseline GFO during information processing. Investigating the link between the state and function of the TC system may conceptually be a key strategy to design innovative therapies against neuropsychiatric disorders. 3The anatomofunctional mechanisms of sensory and cognitive deficits in schizophrenia are unknown. These deficits are commonly associated with abnormal brain rhythms, including disturbances in γ frequency (30-80 Hz) oscillations (GFO) in corticocortical and thalamocortical (TC) circuits (Bokde et al., 2009;Clinton and Meador-Woodruff, 2004;de Haan W. et al., 2009;Friston, 2002;Herrmann and Demiralp, 2005;Light et al., 2006;Lisman, 2011;Meyer-Lindenberg, 2010;Pinault, 2011;Spencer et al., 2003;Uhlhaas and Singer, 2006). At least four types of GFO should be considered: 1) Spontaneously-occurring (baseline) GFO, which are dominant during desynchronized state of the electroencephalogram (Jasper, 1936;Sheer, 1975); 2) Sensory-evoked GFO, which are phase-locked to the stimulus onset (Pantev et al., 1991;Spencer et al., 2008b); 3) Steadystate GFO during r...

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Hallucinations: Synchronisation of thalamocortical γ oscillations underconstrained by sensory input

Cited by 60 publications

References 132 publications

Interrelations between Peculiarities of the Motivational Sphere of a Personality and Characteristics of the Current EEG

Interrelations between Peculiarities of the Motivational Sphere of a Personality and Characteristics of the Current EEG

The thalamic reticular nucleus: structure, function and concept

Opposite effects of ketamine and deep brain stimulation on rat thalamocortical information processing

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