Hallucinations as an adverse effect of angiotensin converting enzyme inhibition

Haffner, C. A.; Smith, B. S.; Pepper, Chris

doi:10.1136/pgmj.69.809.240

Cited by 12 publications

(7 citation statements)

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“…Third, study of Wahlbeck et al revealed increased expression of the ACE in response to some stimuli in chronic schizophrenia patients [30]. Finally, clinical observation also found that acute psychosis could be developed as an adverse effect of angiotensin I-converting enzyme inhibition (such as captopril and quinapril) [31,32].…”

Section: Discussionmentioning

confidence: 96%

Genetic polymorphism of the angiotensin converting enzyme and l-dopa-induced adverse effects in Parkinson's disease

Lin

Yueh

Lin

et al. 2007

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 96%

Genetic polymorphism of the angiotensin converting enzyme and l-dopa-induced adverse effects in Parkinson's disease

Lin

Yueh

Lin

et al. 2007

Journal of the Neurological Sciences

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“…Some studies report anecdotal evidence of confusion, psychosis, and delirium in patients receiving calcium channel blocker therapy 46–52 . Angiotensin‐converting enzyme inhibitors have also been associated with symptoms of delirium including psychosis and visual hallucinations 53,54 …”

Section: Risk Factors For Pcdmentioning

confidence: 99%

Delirium in the Postoperative Cardiac Patient: A Review

et al. 2005

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A multifactorial model should be applied when considering risk stratification for and prevention of delirium postoperatively. Pharmacologically, conventional antipsychotic agents, such as haloperidol, have long been used to manage delirium. In light of haloperidol's side effects, particularly those applicable to the cardiac patient, further research is required into the role of second generation antipsychotics. These agents are common in clinical use, and may be the preferred medications.

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“…Commonly reported adverse effects of ACE inhibitors include cough, rash, angioedema, hypotension, hyperkalemia, and renal insufficiency . Visual hallucinations as an adverse effect of ACE inhibitors are not listed in recent reviews of this drug class but have been reported, primarily in elderly persons . Given the rapid aging of Western populations and the increasing use of antihypertensive therapy to reduce cardiovascular events in the very elderly, it is important for clinicians to be aware of this potential adverse effect of ACE inhibitor therapy.…”

mentioning

confidence: 99%

“…1,3 Visual hallucinations as an adverse effect of ACE inhibitors are not listed in recent reviews of this drug class but have been reported, primarily in elderly persons. [5][6][7][8][9][10][11] Given the rapid aging of Western populations and the increasing use of antihypertensive therapy to reduce cardiovascular events in the very elderly, it is important for clinicians to be aware of this potential adverse effect of ACE inhibitor therapy. In this paper we report 4 cases of visual hallucinations associated with lisinopril therapy.…”

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confidence: 99%

Visual Hallucinations Related to Angiotensin‐Converting Enzyme Inhibitor Use: Case Reports and Review

Doane

Stults

2013

J of Clinical Hypertension

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Four patients experienced visual hallucinations that appear to have been precipitated by lisinopril. Other cases of visual hallucinations have been reported with other angiotensin‐converting enzyme (ACE) inhibitors. Older patients, particularly those with a history of either dementia or mild cognitive impairment, may be at higher risk. Hallucinations resolved within 1 to 30 days after cessation of ACE inhibitors. Development of visual hallucinations after initiation of ACE inhibitors should prompt discontinuation of therapy. Visual hallucinations have been reported in one case involving an ARB. Visual hallucinations have not been associated with direct renin inhibitors. Consideration should be given to use of alternative, unrelated antihypertensive drug classes.

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Hallucinations as an adverse effect of angiotensin converting enzyme inhibition

Cited by 12 publications

References 1 publication

Genetic polymorphism of the angiotensin converting enzyme and l-dopa-induced adverse effects in Parkinson's disease

Genetic polymorphism of the angiotensin converting enzyme and l-dopa-induced adverse effects in Parkinson's disease

Delirium in the Postoperative Cardiac Patient: A Review

Visual Hallucinations Related to Angiotensin‐Converting Enzyme Inhibitor Use: Case Reports and Review

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