Halloysite for Controllable Loading and Release

Abdullayev, Elshad; Lvov, Yuri

doi:10.1016/b978-0-08-100293-3.00022-4

Cited by 34 publications

(15 citation statements)

References 75 publications

(79 reference statements)

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“…It was estimated about 5 mg of T1 and T3 and 10 mg of T2, for 100 mg of HAL, were effectively retained by the nanotubular powder ( Figure 2 ). Lower measures of drug retention by HAL, than ones calculated for laminar and fibrous clays [ 13 , 14 ], were in accordance with HAL loading efficiency values ranging between 5 and 13%, reported for several drugs [ 7 ].…”

Section: Resultssupporting

confidence: 83%

“…In this field, halloysite (HAL), an aluminosilicate clay of the kaolin group, was extensively used as carrier of drugs for its advantageous nanosized tubular structure of around 600–800 nm in length and ~0.1 μm in external diameter [ 5 , 6 ]. Morphologically, HAL consists of a rolled bilayer of an outer negatively charged tetrahedral silicate sheet and an inner positively charged octahedral aluminum sheet, which offer the possibility of neutralization with different chemical entities [ 7 ]. HAL was investigated as an inorganic material able to retain essential oils, particularly carvacrol (CAR), a phenolic monoterpene with various biological and pharmacological properties [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Wound-Healing Properties of Water-Soluble Terpenoids Loaded on Halloysite Clay

et al. 2021

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Recently, mineral healing clays have gained much attention for wound-dressing applications. Here, we selected halloysite (HAL) clay as a biocompatible, non-toxic material that is useful as a drug delivery system to enhance the healing properties of water-soluble terpenoids 1-3 (T1-3). Terpenoids-loaded HAL clay (TH1-3) was prepared and characterized by adsorption equilibrium studies, X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy, and release studies. The results reveal that T1-3 were adsorbed at the HAL surface with good efficiency. The prevalent mechanism of drug retention is due to the adsorption via electrostatic interactions between the cationic groups of the T1-3 and the HAL’s external surface. Release studies demonstrated that T3 was released in a higher percentage (>60%) compared to T1-2 (≈50%). Additionally, TH1-3 were assessed for their antimicrobial activity and capability to promote the re-epithelialization of scratched HaCat monolayers, through the time-kill test and the wound-healing assays, respectively. The results reveal that all the tested formulations were able to reduce the microbial growth after 1 h of incubation and that they ensured complete wound closure after 48 h. Furthermore, at the concentration of 1 µg/mL, TH3 exhibited 45% wound closure at 24 h, compared to TH1 (27%) and TH2 (30%), proving to be the best candidate in making the tissue-repair process easier and faster.

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Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

In Vitro Wound-Healing Properties of Water-Soluble Terpenoids Loaded on Halloysite Clay

et al. 2021

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“…One of the most remarkable features of HNTs is their different surface chemistries at the inner and outer sides of the tubes: silica sheets make up the external surfaces of the tubes and aluminum oxide makes up the inner (lumen) surface chemistry. Furthermore, alumina has a positive charge up to pH 8.5, and silica has a negative charge at pH values above 1.5 [10,11]. Due to differently charged outer and inner sides, it is possible to utilize HNTs as multifunctional nanocontainers for the selective modification of the outer and inner sides of nanotubes [7,[11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineering

et al. 2022

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Due to its slow degradation rate, polycaprolactone (PCL) is frequently used in biomedical applications. This study deals with the development of antibacterial nanofibers based on PCL and halloysite nanotubes (HNTs). Thanks to a combination with HNTs, the prepared nanofibers can be used as low-cost nanocontainers for the encapsulation of a wide variety of substances, including drugs, enzymes, and DNA. In our work, HNTs were used as a nanocarrier for erythromycin (ERY) as a model antibacterial active compound with a wide range of antibacterial activity. Nanofibers based on PCL and HNT/ERY were prepared by electrospinning. The antibacterial activity was evaluated as a sterile zone of inhibition around the PCL nanofibers containing 7.0 wt.% HNT/ERY. The morphology was observed with SEM and TEM. The efficiency of HNT/ERY loading was evaluated with thermogravimetric analysis. It was found that the nanofibers exhibited outstanding antibacterial properties and inhibited both Gram- (Escherichia coli) and Gram+ (Staphylococcus aureus) bacteria. Moreover, a significant enhancement of mechanical properties was achieved. The potential uses of antibacterial, environmentally friendly, nontoxic, biodegradable PCL/HNT/ERY nanofiber materials are mainly in tissue engineering, wound healing, the prevention of bacterial infections, and other biomedical applications.

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“…Also, several chapters in the book Nanosized Tubular Clay Minerals -Halloysite and Imogolite 21 give an excellent overview on HNTs mineralogy, 22,23 methods for characterization, 24,25 safety considerations, 26 modification strategies, 27,28 and applications. [29][30][31][32][33] Additional more recent reviews which highlight the physical and chemical modification of HNTs for a range of future applications are. 15,34,35 Other noteworthy reviews by leading research groups in the field focus on the prominent biomedical avenues [16][17][18][19]35,36 in general, and drug delivery in particular.…”

Section: Noteworthy Background Literaturementioning

confidence: 99%