Half-lives of serum PCB congener concentrations in environmentally exposed early adolescents

Wimmerová, Soňa; Lancz, Kinga; Tihányi, Juraj; Šovčíková, Eva; Kočan, Anton; Drobná, Beata; Palkovičová, Ľubica; Jurečková, Dana; Fabišíková, Anna; Čonka, Kamil; Trnovec, T.

doi:10.1016/j.chemosphere.2010.10.099

Cited by 32 publications

(14 citation statements)

References 25 publications

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“…This finding appears to be in line with what is previously reported in the literature [42, 43]. PCBs 52, 101, 110, and 66 were detected at fairly high levels in both urine and sweat.…”

Section: Resultssupporting

confidence: 93%

Biomonitoring and Elimination of Perfluorinated Compounds and Polychlorinated Biphenyls through Perspiration: Blood, Urine, and Sweat Study

Genuis

Beesoon

Birkholz³

2013

ISRN Toxicology

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Perfluorinated compounds (PFCs) are man-made organofluorine chemicals manufactured and marketed for their stain-resistant properties. Polychlorinated biphenyls (PCBs) are anthropogenic organochlorine compounds previously used in various industrial and chemical applications prior to being banned in the Western world in the 1970s. Both PFCs and PCBs are persistent contaminants within the human organism and both have been linked to adverse health sequelae. Data is lacking on effective means to facilitate clearance of PFCs and PCBs from the body. Methods. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for PFCs and PCBs using high performance liquid chromatography tandem mass spectrometry. Results. Some individual PCB congeners, but not all, were released into sweat at varying concentrations. None of the PFCs found in serum testing appeared to be excreted efficiently into perspiration. Conclusions. Induced perspiration may have some role in facilitating elimination of selected PCBs. Sweat analysis may be helpful in establishing the existence of some accrued PCBs in the human body. Sweating does not appear to facilitate clearance of accrued PFHxS (perfluorohexane sulfonate), PFOS (perfluorooctane sulfonate), or PFOA (perfluorooctanoic acid), the most common PFCs found in the human body.

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“…This finding appears to be in line with what is previously reported in the literature [42, 43]. PCBs 52, 101, 110, and 66 were detected at fairly high levels in both urine and sweat.…”

Section: Resultssupporting

confidence: 93%

Biomonitoring and Elimination of Perfluorinated Compounds and Polychlorinated Biphenyls through Perspiration: Blood, Urine, and Sweat Study

Genuis

Beesoon

Birkholz³

2013

ISRN Toxicology

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“…The same holds for PCB waste stores. This assumption is supported by observation of exposure to PCBs in adolescents living in this area (Wimmerova et al 2011). …”

Section: Discussionsupporting

confidence: 59%

The spatial distribution of human exposure to PCBs around a former production site in Slovakia

Wimmerová

Watson²,

Drobná

et al. 2015

Environ Sci Pollut Res

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We evaluated concentrations of 15 PCB congeners in blood serum of 2,047 adults, 431 8-9-years old children and 1,134 mother-child pairs born in 2001-2003. These subjects were long-standing residents living up to 70 km (to the north) and up to 50 km (to the south) of the former Chemko Strážske PCB production facility in the Michalovce district of Slovakia. We plotted serum concentration against distance from the plant both with and without consideration of the direction of their homes from the site. The decrease in exposure with distance could be described by an exponential function which was dependent on direction and climatic parameters. By kriging we created maps depicting predicted isoconcentration contours for sex- and age-adjusted serum concentration of ΣPCBs for the same group of children, adults and mothers. The principle of our risk analysis was to relate serum concentration data, reflecting PCB body burden, using the critical concentrations established by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES 2010) as thresholds below which the probability of effects on health is regarded as negligible. We conclude that 10 years ago around 200,000 residents were at risk in this densely populated area. Exposure has since decreased but the mechanism for this has not yet been studied.

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“…These can occur with normal food, but in infancy may be rare. If the child is living in an area highly polluted by PCBs and after weaning is fed by food produced locally (Sonneborn et al, 2008a, 2008b), reuptakes at adolescent age can occur, as we have shown previously (Wimmerová et al, 2011). A slight modification of the weaning time usually improved the fit.…”

Section: Resultssupporting

confidence: 57%

Duration of breastfeeding and serum PCB 153 concentrations in children

Lancz¹,

Hertz‐Picciotto²,

Jusko³

et al. 2015

Environmental Research

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Polychlorinated biphenyls (PCBs) are toxic, persistent, and bioaccumulative chemicals which, because of their lipophilic properties, are abundant in human breast milk. Breastfed infants are therefore at risk of being exposed to considerable amounts of PCBs. The commonly used exposure estimations, based solely on breast milk PCB levels and duration of breastfeeding, may lead to exposure misclassification. To improve assessments of exposure to PCBs, we determined PCB 153 serum concentration, as a model substance for PCBs, at the critical time of weaning for each child in 305 breastfed infants from 5 single time point concentration measurements spread over 7 years and data on duration of breastfeeding, using an earlier developed model of the system type. We approximated the dependence of PCB 153 serum concentration, Ctbf, adjusted to cord serum concentration, C0, on nursing period, by a polynomial function Ctbf/C0=0.596+0.278t−0.0047t2 which reliably predicts exposure to PCB 153 of breastfed infants, important for assessment of dose-outcome relationships. Adjustment of current serum concentrations to cord serum concentration improved validity of exposure assessment.

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Half-lives of serum PCB congener concentrations in environmentally exposed early adolescents

Cited by 32 publications

References 25 publications

Biomonitoring and Elimination of Perfluorinated Compounds and Polychlorinated Biphenyls through Perspiration: Blood, Urine, and Sweat Study

Biomonitoring and Elimination of Perfluorinated Compounds and Polychlorinated Biphenyls through Perspiration: Blood, Urine, and Sweat Study

The spatial distribution of human exposure to PCBs around a former production site in Slovakia

Duration of breastfeeding and serum PCB 153 concentrations in children

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