Half-life measurement of the medical radioisotope 177Lu produced from the 176Yb(n,γ) reaction

Ferreira, Kelley; Collins, S.M.; Fenwick, Andrew

doi:10.1051/epjconf/201714608002

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…iii) The undesirable 177m Lu (t 1/2 ≈160 d) is produced in the direct route, 0.05%, whereas in the indirect route it is less than 10 -5 % [16]. 177m Lu creates important problems, the urine of the patient must be treated as radioactive waste, and the patient receives an undesirable dose.…”

Section: Introductionmentioning

confidence: 99%

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First high resolution measurement of neutron capture resonances in ¹⁷⁶Yb at the n_TOF CERN facility

García-Infantes¹,

Praena²,

Casanovas³

et al. 2023

EPJ Web of Conf.

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Several international agencies recommend the study of new routes and new facilities for producing radioisotopes with application to nuclear medicine. 177Lu is a versatile radioisotope used for therapy and diagnosis (theranostics) of cancer with good success in neuroendocrine tumours that is being studied to be applied to a wider range of tumours. 177Lu is produced in few nuclear reactors mainly by the neutron capture on 176Lu. However, it could be produced at high-intensity celeratorbased neutron facilities. The energy of the neutrons in accelerator-based neutron facilities is higher than in thermal reactors.Thus, experimental data on the 176Yb(n,γ) cross-section in the eV and keV region are mandatory to calculate accurately the production of 177Yb, which beta decays to 177Lu. At present, there are not experimental data available from thermal to 3 keV of the 176Yb(n,γ) cross-section. In addition, there is no data in the resolved resonance region (RRR). This contribution shows the first results of the 176Yb capture measurement performed at the n_TOF facility at CERN.

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Section: Introductionmentioning

confidence: 99%

“…These properties have a direct impact on the quality of the diagnosis and the therapy. The higher specific activity allows a much better tumour uptake; thus, the dose deliver to tumour for the same activity is much higher in case of the indirect route, and in addition, the quality of imaging of the tumour is much better [15,16].…”

Section: Introductionmentioning

confidence: 99%

First high resolution measurement of neutron capture resonances in ¹⁷⁶Yb at the n_TOF CERN facility

García-Infantes¹,

Praena²,

Casanovas³

et al. 2023

EPJ Web of Conf.

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“…With the enhanced rigor in experimental execution and data analysis, the metrological community is currently achieving better consistency at a higher level of accuracy than in the past. Examples of recently achieved convergence are the improved half-life values for 55 Fe [7,8], 109 Cd [9][10][11], 177 Lu [12][13][14][15][16], 209 Po [17][18][19], 225 Ac [20,21], 223 Ra [22,23], and 227 Th [24,25].…”

Section: Introductionmentioning

confidence: 99%

Empirical decomposition and error propagation of medium-term instabilities in half-life determinations

Pommé

Pelczar

2021

Metrologia

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A least-squares fit of exponential functions to a measured radioactive decay rate curve provides an estimate of the half-life and its statistical uncertainty in the assumption that all deviations from the theoretical curve are purely of a random nature. The result may be biased and the error underestimated as soon as the experiment suffers instabilities that exceed the duration of individual measurements. Contrary to long-term systematic errors, medium-frequency cyclic perturbations may be observable as autocorrelated structures in the residuals. In this work, an empirical decomposition algorithm is used to separate medium-frequency effects from the random statistical component in the fit residuals, such that custom error propagation factors can be calculated. A theoretical study of error propagation is made for sine and square wave perturbations. The empirical decomposition method is demonstrated on a synthetic spectrum, a time series of solar neutrino detection rates, and two experimental decay curves of 134Cs measured in an ionisation chamber.

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Need for enrichment of lutetium isotope and design of a laser based separator module

Majumder,

Pulhani,

Ghosh

et al. 2023

Applied Radiation and Isotopes

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Half-life measurement of the medical radioisotope ¹⁷⁷Lu produced from the ¹⁷⁶Yb(n,γ) reaction

Cited by 4 publications

References 21 publications

First high resolution measurement of neutron capture resonances in ¹⁷⁶Yb at the n_TOF CERN facility

First high resolution measurement of neutron capture resonances in ¹⁷⁶Yb at the n_TOF CERN facility

Empirical decomposition and error propagation of medium-term instabilities in half-life determinations

Need for enrichment of lutetium isotope and design of a laser based separator module

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Half-life measurement of the medical radioisotope 177Lu produced from the 176Yb(n,γ) reaction

Cited by 4 publications

References 21 publications

First high resolution measurement of neutron capture resonances in 176Yb at the n_TOF CERN facility

First high resolution measurement of neutron capture resonances in 176Yb at the n_TOF CERN facility

Empirical decomposition and error propagation of medium-term instabilities in half-life determinations

Need for enrichment of lutetium isotope and design of a laser based separator module

Contact Info

Product

Resources

About

Half-life measurement of the medical radioisotope ¹⁷⁷Lu produced from the ¹⁷⁶Yb(n,γ) reaction

First high resolution measurement of neutron capture resonances in ¹⁷⁶Yb at the n_TOF CERN facility

First high resolution measurement of neutron capture resonances in ¹⁷⁶Yb at the n_TOF CERN facility