Hairy cell leukemia with ringed-shaped nuclei

Woessner, S; Lafuente, R; Florensa, Lourdes; Marill, M. R.; Sans-Sabrafén, J

doi:10.1007/bf00349070

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…We speculate that administration of prednisone (steroids) as well as probably other factors might increase numbers of HC with a ring-shaped nucleus, because of the known cytotoxic effect of steroids on cells originating from the B-lymphocytic lineage. In the literature, we found only two other patients with HCL and ringshaped (or doughnut-like) HC nuclei, but the use of corticosteroids or influence of other factors was not reported in them [5,9].…”

Section: Discussionmentioning

confidence: 89%

“…Other cytological forms of HC nuclei, except round, oval or indented, were described in HCL as kidney-shaped [4,5], folded [21], convoluted/overlapped [9,22,23], lobulated or multilobular [5,[23][24][25], dumb-bell, spindle or horseshoe-shaped nuclei [5,22,26]. In our series, none of these types represented more than 7% of the total HC, and the sum of cells with these types of nuclei was highest (19.5%) in the patient with the highest number of ring-shaped HC nuclei.…”

Section: Discussionmentioning

confidence: 99%

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Variations of hairy cell nuclei shapes with regard to ring‐shaped nuclei simulating dysplastic neutrophilic granulocytes and review of the literature

Lemez

Kačírková

2014

Int J Lab Hematology

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Variations of hairy cell nuclei shapes with regard to ring‐shaped nuclei simulating dysplastic neutrophilic granulocytes and review of the literature

Lemez

Kačírková

2014

Int J Lab Hematology

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Hairy cell leukemia with ring-shaped nuclei

Lemez

Friedmann

Vaňásek

et al. 1990

Blut

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Unusual nuclear form hairy cells in hairy cell leukemia discovered using a lymphocyte-binding anti-CD antibody microarray.

Khvastunova

Al-Radi²,

Fedyanina

et al. 2018

Klin. med.

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Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder constituting about 2% from all leukemia cases and characterized by typical “hairy” morphology of tumor lymphocytes. We describe an HCL case with atypical nuclear shapes (lymphocytes with clover-leaf-like, horse-shoe-like, ring-shaped nuclei and binuclear cells were present). Morphology and immunophenotype of circulating leukemic cells were studied using a cell-binding microarray - a transparent plastic slide with immobilized monoclonal antibodies against surface antigens of lymphocytes. The cell-binding microarray with immobilized anti-CD11c, anti-CD103 and anti-CD123 permits to study a lymphocyte population enriched with hairy cells. Hairy cells with atypical nuclei constituted 3% of all lymphocytes and 15% of all hairy cells. This unusual hairy cell morphology is the first described in Russia and was found in one out of 85 HCL cases in our practice.

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Hairy cell leukemia with ringed-shaped nuclei

Cited by 3 publications

References 5 publications

Variations of hairy cell nuclei shapes with regard to ring‐shaped nuclei simulating dysplastic neutrophilic granulocytes and review of the literature

Variations of hairy cell nuclei shapes with regard to ring‐shaped nuclei simulating dysplastic neutrophilic granulocytes and review of the literature

Hairy cell leukemia with ring-shaped nuclei

Unusual nuclear form hairy cells in hairy cell leukemia discovered using a lymphocyte-binding anti-CD antibody microarray.

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