Hairy cell leukemia: splenectomy after alpha 2b-interferon therapy [letter] [see comments]

Ga, Pangalis; Boussiotis, VA; Kittas, C; Panayiotidis, PG; Loukopoulos, D; Fessas, P; Mitsoulis-Mentzikoff, C

doi:10.1182/blood.v78.5.1385a.bloodjournal7851385a

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Role Ofsplenectomy In Hcl In the 'Tfnera"1

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1995

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“…The role of splenectomy in HCL after IFN treatment was introduced is still a matter of debate. Several groups have reported a slower and somewhat inferior response to IFN treatment in non-splenectomized compared to splenectomized patients (y162, 166), and there is evidence for HC remaining in the spleen after clearance from other sites (196). As a high number of patients respond with long-lasting partial remissions after splenectomy (10,158), it has, therefore, been proposed to splenectomize some, or maybe even all, HCL patients either before or after IFN therapy (197).…”

Section: Role Ofsplenectomy In Hcl In the 'Tfnera"mentioning

confidence: 99%