Hairy-cell Leukaemia-associated Polyarthritis: a Report of Two Cases

Cancer polyarthritis resembling rheumatoid arthritis as a first sign of hidden neoplasms: Report of two cases and review of the literature

“…The arthritis of acute leukemia is commonly asymmetric, polyarticular, and often part of the initial manifestation of the disease; the arthritis associated with chronic leukemia is similar, but more often symmetric and usually appears as a late manifestation of the malignant disorder (28). Malignant cell in® ltration of the synovium as a cause of polyarthritis has been reported in patients with T cell (29) and B cell lymphomas and leukemias (7). In a detailed review of``leukemic arthritis' ' (LA), Evans 1994 (25) has described LA as a commonly asymmetric pauciarticular disorder (occurring in both children and adults) with direct in® ltration of the synovium and highlighted the importance of synovial biopsy for differential diagnosis.…”

Lymphomatous variant of hairy cell leukaemia: a distinctive presentation mimicking low‐grade B‐cell lymphoma

“…Lymphadenopathy is uncommon in HCL patients, unless the disease is advanced or progressive. Patients with HCL rarely develop a solitary mass involving extranodal sites, such as the skeletal bones, breast, brain, skin, and joints, and extranodal masses most often occur during relapse of long‐standing disease. Fortunately, most patients who have extranodal sites of disease also show simultaneous classic leukaemic manifestations, making the diagnosis straightforward.…”

Hairy Cell Leukemia (HCL) Presenting with Joint Swelling: Case Report and Literature Review of a Rare Rheumatological Manifestation of a Hematological Disease

“…The case reported by L'Hirondel et al describes short-lived polyarthritis symptoms resolved rapidly with alpha-2 interferon therapy [12]. Establishing a diagnosis is often complicated as HCL has also been observed to cause nonimmune polyarthritis with synovial fluid identification of hairy cells as demonstrated by Zervas et al [13]. HCL-V has been reported to develop painful joint disease due to leukemic infiltration causing bony expansion [7].…”

“…Interestingly, HCL is recognized as a rare predisposing factor for RA [10]. Zervas et al describe a case of HCL later developing RA [13]. Taylor et al report a case of seropositive inflammatory arthritis that developed in an HCL patient who received alpha interferon therapy [14].…”