Hair versus urine for the biomonitoring of pesticide exposure: Results from a pilot cohort study on pregnant women

Hardy, Emilie; Dereumeaux, Clémentine; Guldner, Laurence; Briand, Olivier; Vandentorren, Stéphanie; Oleko, Amivi; Zaros, Cécile; Appenzeller, Brice

doi:10.1016/j.envint.2021.106481

Cited by 48 publications

(19 citation statements)

References 50 publications

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“…Fipronil can be degraded into metabolites in the environment, mainly including fipronil desulfinyl, fipronil sulfone, and fipronil sulfide . Fipronil and its metabolites have been found in environmental samples, such as surface water, drinking water, indoor and outdoor dust, − and food samples, − including vegetables, dietary samples, eggs, milk, teas, etc., as well as biological samples, ,− such as urine, serum, and hair. All of these indicate that fipronil is ubiquitous in the environment.…”

Section: Introductionmentioning

confidence: 99%

Human Exposure of Fipronil Insecticide and the Associated Health Risk

Chen

Zhao

et al. 2021

J. Agric. Food Chem.

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Fipronil, as an emerging phenylpyrazole insecticide, is ubiquitous in the environment and food due to its broad spectrum and persistent characteristics, but the research on pathways of human exposure to fipronil and the associated health risk is relatively unclear. In this regard, we summarize potential human exposures to fipronil through ingestion and inhalation, as well as results of human biomonitoring studies. This scientific information will contribute to future assessment of fipronil exposure and subsequent characterization of human health risks. Additionally, this Perspective highlights the lack of epidemiological studies and total diet studies for the general population on fipronil.

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Section: Introductionmentioning

confidence: 99%

Human Exposure of Fipronil Insecticide and the Associated Health Risk

Chen

Zhao

et al. 2021

J. Agric. Food Chem.

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“…Hair matrix has proven to be efficient in assessing pesticide exposure over a period covering weeks to months 32 , 33 , despite not providing toxicokinetic information. Moreover, the hair matrix offers another advantage in epidemiological studies, as it is not sensitive to intraday variabilities like urine and plasma compartments 34 , 35 . However, there is hitherto no reference range available to classify pesticide poisoning in the hair so that we can congruently estimate the level of intoxication Andean people face.…”

Section: Discussionmentioning

confidence: 99%

“…10 UMR 224 MIVEGEC, IRD, CNRS UMR 5290, Université de Montpellier, Montpellier, France. 11 Faculté de Pharmacie, UMR 152 PHARMADEV, 35 Chemin des Maraîchers, 31000 Toulouse, France. 12 These authors contributed equally: Jorge Honles and Claire Clisson.…”

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confidence: 99%

Exposure assessment of 170 pesticide ingredients and derivative metabolites in people from the Central Andes of Peru

Honles

Clisson²,

Monge

et al. 2022

Sci Rep

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The Central Andes of Peru are a region of great concern regarding pesticide risk to the health of local communities. Therefore, we conducted an observational study to assess the level of pesticide contamination among Andean people. Analytical chemistry methods were used to measure the concentrations of 170 pesticide-related compounds in hair samples from 50 adult Andean subjects living in rural and urban areas. As part of the study, a questionnaire was administered to the subjects to collect information regarding factors that increase the risk of pesticide exposure. Our results indicate that Andean people are strongly exposed to agrochemicals, being contaminated with a wide array of pesticide-related compounds at high concentration levels. Multivariate analyses and geostatistical modeling identified sociodemographic factors associated with rurality and food origin that increase pesticide exposure risk. The present study represents the first comprehensive investigation of pesticide-related compounds detected in body samples collected from people living in the Central Andes of Peru. Our findings pinpoint an alarming environmental situation that threatens human health in the region and provide a rationale for improving public policies to protect local communities.

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“…(1) Pesticides, PCBs, PBDEs and bisphenols: Once the samples were dried, they were placed in a stainless grind jar for pulverization using a ball mill Retsch MM200 at 25 Hz. 50 mg of hair powder per sample were placed in a 4 ml screw neck glass vials (La-Pha-Pack) with 10 µl of internal standard solution (stable isotope labelled analogues (Hardy et al, 2015) The methodology followed was validated and fully described in Hardy et al (2015) and Beranger et al (2018), and used in previous publications (Beranger et al 2018;Iglesias-González et al 2020;Peng et al 2020bPeng et al , 2020aHardy et al 2021).…”

Section: Decontamination and Extractionmentioning

confidence: 99%

Comprehensive Assessment of Local Population Chemical Exposome by Combination of Organic Pollutant- and Metal-Multi-Residue Analysis in Hair

et al. 2021

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Awareness of the adverse effects of exposure to pollutant mixtures, possibly much more severe than individual chemicals, has drawn attention towards the necessity of using multi-residue methods to obtain the most possible comprehensive information on exposome. Among the different biological matrices used for exposure assessment, hair enables to detect the largest number of chemicals, including many classes such as persistent pollutants, hydrophilic metabolites and metals. Most biomonitoring studies are however focused on a limited number of pollutants and only give a partial information on exposure. Combining several multi-residue methods, the present study aimed at assessing the exposure of a population to an extensive variety of chemicals by hair analysis. One hair sample was collected from each participant (55 children and 134 adults). Samples were analysed with three different multi-residue methods, targeting, respectively, 152 organic pollutants (pesticides, PCBs, bisphenols, PBDEs), 62 polycyclic aromatic hydrocarbons (PAHs) and metabolites, nicotine and cotinine and 36 metals. From 33 to 70 organic chemicals were detected in each child’s hair sample, and from 34 up to 74 in adults. From 7 to 26 PAH were detected per child, and 7 to 21 in adults. Twenty-three to 27 metals were detected per child and 21 to 28 per adult. The highest median concentration were observed for zinc (143 μg /mg in children; 164 μg /mg in adults), bisphenol A (95.9 pg/mg in children; 64.7 pg/mg in adults) and nicotine (66.4 pg/mg in children; 51.9 pg/mg in adults). The present study provides the most comprehensive exposure assessment ever and highlights the simultaneous exposure to multiple classes of pollutants in the general population. The results support the use of multi-residue methods for future studies on exposure-associated effects, to document exposome and better consider the effect of chemical mixtures.

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Hair versus urine for the biomonitoring of pesticide exposure: Results from a pilot cohort study on pregnant women

Cited by 48 publications

References 50 publications

Human Exposure of Fipronil Insecticide and the Associated Health Risk

Human Exposure of Fipronil Insecticide and the Associated Health Risk

Exposure assessment of 170 pesticide ingredients and derivative metabolites in people from the Central Andes of Peru

Comprehensive Assessment of Local Population Chemical Exposome by Combination of Organic Pollutant- and Metal-Multi-Residue Analysis in Hair

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