Hair Sample Preparation, Extraction, and Screening Procedures for Drugs of Abuse and Pharmaceuticals

Kronstrand, Robert; Forsman, Malin; Seldén, Tor

doi:10.1016/b978-0-12-801700-5.00002-9

Cited by 2 publications

(2 citation statements)

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“…7 To gain this level of sensitivity, different steps are implemented for hair specimen screening such as extraction, decontamination, purication, and detection followed by quantication at the sub-picogram level. 8 Analysis of drugs from hair samples depends on parameters such as sensitivity of the analytical method and the ingested dose of cannabis. 9 Hair analysis also depends on the route of administration of a compound, duration of administration, purity of drug, amount of available hair sample, and pH of solvent used for sample preparation.…”

Section: Introductionmentioning

confidence: 99%

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Analytical techniques for screening of cannabis and derivatives from human hair specimens

Kale,

Chaturvedi,

Dandekar

et al. 2024

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

“…7 To gain this level of sensitivity, different steps are implemented for hair specimen screening such as extraction, decontamination, purification, and detection followed by quantification at the sub-picogram level. 8…”

Section: Introductionmentioning

confidence: 99%

Analytical techniques for screening of cannabis and derivatives from human hair specimens

Kale,

Chaturvedi,

Dandekar

et al. 2024

Anal. Methods

View full text Add to dashboard Cite

show abstract

Pulverization Is a Crucial Step—A Comparative Study of Different Pretreatments in Hair Drug Testing

Chen

Liu

et al. 2023

Journal of Analytical Toxicology

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In forensic toxicology, hair has become a hot biological material for drug testing due to its wider detection window and noninvasive sampling process compared to traditional liquid biological materials (e.g., blood and urine). However, hair as a matrix differs from body fluids, as it is not as easily aliquoted for analysis. Nevertheless, pretreatment methods for hair detection have gradually improved from the first chemical methods, such as alkali digestion and acid hydrolysis, to now include the physical method of pulverization, and further improvements beyond “pulverization” protocols. In a previous study, we updated and developed a “micropulverized extraction” method. In the present study, our aim was to gain a more complete understanding of the “micropulverized extraction” method by comparing pulverization temperature and hair particle size, as these two factors are known to influence the effectiveness of sample processing. The analytes we selected were those commonly encountered in traditional drug abuse cases: (±)-methamphetamine, (±)-amphetamine, morphine, 6-acetylmorphine, cocaine, benzoylecgonine, (-)-Δ9-tetrahydrocannabinol, ketamine, (±)-norketamine, and (±)3,4-methylenedioxymethamphetamine. The analysis method was liquid chromatography-tandem mass spectrometry.

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Hair Sample Preparation, Extraction, and Screening Procedures for Drugs of Abuse and Pharmaceuticals

Cited by 2 publications

References 54 publications

Analytical techniques for screening of cannabis and derivatives from human hair specimens

Analytical techniques for screening of cannabis and derivatives from human hair specimens

Pulverization Is a Crucial Step—A Comparative Study of Different Pretreatments in Hair Drug Testing

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