Hair regrowth boosting via minoxidil cubosomes: Formulation development, in vivo hair regrowth evaluation, histopathological examination and confocal laser microscopy imaging

Makhlouf, Amal; Elnawawy, Tayseer

doi:10.1016/j.ijpharm.2023.122665

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…ZP is an important parameter to evaluate the stability and biodistribution of colloidal dispersions (Zhang and Wu, 2021). Generally, high surface charges lead to electrostatic repulsion between particles, thereby preventing them from aggregation (Makhlouf and Elnawawy, 2023). In this study, the prepared PCcubosomes showed a high absolute ZP values ranged from −26.4 ± 1.3 mV (F9) to −33.9 ± 1.1 mV (F1) (Table 3), which could effectively avoid particle aggregation.…”

Section: Zpmentioning

confidence: 67%

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Improving the stability and transdermal permeability of phycocyanin loaded cubosomes

Zhu,

Duan,

Jing

et al. 2024

Front. Nanotechnol.

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Instability and low transdermal permeability of protein antioxidants are major obstacles to resist oxidative stress in transdermal drug delivery system. To overcome these shortcomings, cubosomes were developed as an advanced transdermal delivery system to improve stability and transdermal absorption of the model antioxidant phycocyanin in this study. Glyceryl monooleate and poloxamer 407 (P407) were used to prepare cubosomes as carrier matrix and stabilizer, respectively. Phycocyanin loaded cubosomes (PC-cubosomes) were prepared by the emulsification and homogenization method. A 33 full factorial design was used to optimize the cubosome formulations. The final optimal PC-cubosomes possessed an average particle size of 183.2 ± 0.5 nm and a negative surface charge as well as achieved a high encapsulation efficiency of 87.2% ± 2.7%. PC-cubosomes appeared as nano-sized and well-shaped spheres with highly ordered cubical structures. The residual amount of phycocyanin in PC-cubosomes was 3-fold higher than that in the free drug solution after 10 days ultraviolet radiation exposure. In vitro release kinetics of phycocyanin from PC-cubosomes fitted to the Higuchi kinetic model, indicating that phycocyanin released from cubosomes mainly attributed to drug diffusion and dissolution. PC-cubosomes also exhibited higher permeability (39.79 μg⋅cm−2⋅hour−1) across the rat skin than phycocyanin solution (16.33 μg⋅cm−2⋅hour−1). Furthermore, PC-cubosomes were easily taken up by keratinocytes, thereby achieving a prolonged anti-oxidative stress effect. These results therefore suggested that cubosomes could be a promising transdermal delivery system to improve the stability and transdermal permeability of phycocyanin.

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Section: Zpmentioning

confidence: 67%

“…PC-cubosomes were prepared by melt dispersion emulsification technique with some modifications (Makhlouf and Elnawawy, 2023). As showed in Figure 1, the dispersed phase consisting of GMO and P407 was heated at 50 °C in a water bath to form oil phase.…”

Section: Preparation Of Pc-cubosomesmentioning

confidence: 99%

Improving the stability and transdermal permeability of phycocyanin loaded cubosomes

Zhu,

Duan,

Jing

et al. 2024

Front. Nanotechnol.

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“…The MXD release curve fits well with the Higuchi diffusion kinetics on the basis of the higher regression coefficient value ( R 2 ). The exponent “ n ” in the Korsmeyer–Peppas equation was calculated to be 0.6792, indicating non-Fickian or anomalous drug release (i.e., diffusion and erosion-controlled release) [ 99 ].…”

Section: Mechanism Of Drug Release From Cbsmentioning

confidence: 99%

“…Moreover, the lipid present in the CBs functions as a skin adhesive, increasing the therapeutic action of the drug by increasing the retention time of the drug on the skin. The histopathological photomicrographs explained the effectiveness of treatment with MXD-CBs (group II) in the different layers of the skin, and hair follicles were observed when compared to the control (group I), as shown in Figure 7(b) [ 99 ].…”

Section: Applications Of Cbs In Various Skin Diseasesmentioning

confidence: 99%

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Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Nath,

Dubey,

Kumar

et al. 2024

Journal of Lipids

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Topical drug delivery employing drug nanocarriers has shown prominent results in treating topical ailments, especially those confined to the skin and eyes. Conventional topical formulations persist with drug and disease‐related challenges during treatment. Various nanotechnology‐driven approaches have been adopted to mitigate the issues associated with conventional formulations. Among these, cubosomes have shown potential applications owing to their liquid crystalline structure, which aids in bioadhesion, retention, sustained release, and loading hydrophilic and hydrophobic moieties. The phase transition behavior of glyceryl monooleate, the concentration of stabilizers, and critical packing parameters are crucial parameters that affect the formation of cubosomes. Microfluidics‐based approaches constitute a recent advance in technologies for generating stable cubosomes. This review covers the recent topical applications of cubosomes for treating skin (psoriasis, skin cancer, cutaneous candidiasis, acne, and alopecia) and eye (fungal keratitis, glaucoma, conjunctivitis, and uveitis) diseases. The article summarizes the manufacturing and biological challenges (skin and ocular barriers) that must be considered and encountered for successful clinical outcomes. The patented products are successful examples of technological advancements within cosmeceuticals that support various topical applications with cubosomes in the pharmaceutical field.

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Development and Synthesis of Block Co-polymer and their Role in Nanotechnology

Gautam,

Kaurav,

Kanwar

et al. 2023

Block Co-Polymeric Nanocarriers: Design, Concept, and Therapeutic Applications

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Hair regrowth boosting via minoxidil cubosomes: Formulation development, in vivo hair regrowth evaluation, histopathological examination and confocal laser microscopy imaging

Cited by 9 publications

References 46 publications

Improving the stability and transdermal permeability of phycocyanin loaded cubosomes

Improving the stability and transdermal permeability of phycocyanin loaded cubosomes

Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Development and Synthesis of Block Co-polymer and their Role in Nanotechnology

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