Hair regrowth and maintenance in alopecia universalis patient treated with nonablative Er:YAG laser

McCarthy, Madison; Day, Doris; Talaber, Iva

doi:10.1002/ccr3.4948

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…However, all such studies are conducted in animal models. Finally, a case report of significant hair regrowth in a patient with alopecia universalis following treatment with nonablative Er:YAG laser treatment, PRP, and exosome injections has been described 53 . Further definitive research is required in human clinical trials.…”

Section: Resultsmentioning

confidence: 99%

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Kost

Muskat

Mhaimeed³

et al. 2022

J of Cosmetic Dermatology

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Background: Alopecia is a common chief complaint and is challenging to treat. As such, regenerative treatments to promote hair growth are an emerging area of research. Exosomes, which are extracellular vesicles involved in cell communication, homeostasis, differentiation, and organogenesis, have been shown to play a central role in hair morphogenesis and regeneration with potential for use as alopecia treatment.Aims: This review summarizes and assesses the body of literature surrounding exosomes as regenerative therapeutics for alopecia and identifies areas for improvement in future research.Methods: A review was conducted using a comprehensive list of keywords including "exosome," "alopecia," and "hair loss" on PubMed, EMBASE, and Google Scholar databases published from inception to February 2022. Reference lists of identified articles were included. 47 studies were included. Clinical trial databases were searched using the term "exosome"; however, no trials relevant to hair growth were identified.Results: Our updated and comprehensive review details the history of exosome use in medicine, postulated underlying mechanisms in treating hair loss, and current clinical studies. Preclinical studies demonstrate clear benefits of exosome therapeutics in regenerative medicine and for hair loss treatment. Clinical trials demonstrate safety of exosome use in medicine, but data showing efficacy and safety of exosome therapy for alopecia are lacking. We identified several gaps in knowledge required for effective clinical translation including safety, exosome source, and optimal treatment delivery mechanism and dosage. Conclusion:Exosomes are on the horizon as an exciting therapeutic for the treatment of alopecia. Further studies and clinical trials are required.

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Section: Resultsmentioning

confidence: 99%

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Kost

Muskat

Mhaimeed³

et al. 2022

J of Cosmetic Dermatology

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“…Indeed, several groups have demonstrated that microneedling may be effective in treating AGA ( 24 ) and AA ( 25 ). Both ablative and non-ablative settings of Er:YAG lasers have been used in AGA and AA, with promising results ( 26 – 28 ).…”

Section: The Immune System Interaction With the Hair Follicle Nichementioning

confidence: 99%

Targeted immunotherapy for hair regrowth and regeneration

Toh,

Wang

2023

Front. Med.

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“…7 Traditional treatments, that is, finasteride and minoxidil, have not shown the ability to reverse the fate of terminal atrophic hair follicles in clinical trials. 8 New treatments include stem cells and their products, 9 peroxidases, 10 prostaglandin derivatives, 11 Chinese medicine molecules, 12 and photoelectric therapy, 13 all of which mediate hair follicle regeneration by regulating apoptosis. The stability and regulatory mechanisms of the above treatments remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

CircAGK regulates high dihydrotestosterone‐induced apoptosis in DPCs through the miR‐3180‐5p/BAX axis

Wei

Yang

et al. 2023

The FASEB Journal

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The incidence of androgen alopecia (AGA), also known as seborrheic alopecia, has surged in recent years, and onset is occurring at younger ages. Dermal papilla cells (DPCs) are key to maintaining hair cycling, and apoptosis‐driven processes in DPCs are closely related to hair follicle regeneration. Circular RNAs (circRNAs) are widely present in the human body and are closely related to the occurrence and development of many diseases. Currently, the biological functions of circRNAs in AGA are largely unknown. Whole‐transcriptome sequencing was used to screen differential circRNA expression profiles between AGA patients and non‐AGA patients. We found that hsa_circ_0002980 (circAGK) was significantly highly expressed in the AGA group. CircAGK promoted DPC apoptosis in the presence of high dihydrotestosterone (DHT) (15 nmol/L). By regulating the miR‐3180‐5p/BAX axis, circAGK promotes DPC apoptosis in a high DHT environment in vitro and inhibits hair growth in AGA mice in vivo, indicating that circAGK is a potential target for the clinical treatment of AGA.

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Hair regrowth and maintenance in alopecia universalis patient treated with nonablative Er:YAG laser

Cited by 5 publications

References 15 publications

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Targeted immunotherapy for hair regrowth and regeneration

CircAGK regulates high dihydrotestosterone‐induced apoptosis in DPCs through the miR‐3180‐5p/BAX axis

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