Hair, nail, and pigment changes in major systemic disease

Relapsing features of bile salt export pump deficiency after liver transplantation in two patients with progressive familial intrahepatic cholestasis type 2

“…The presence of associated extra-hepatic phenomena, not yet reported in this condition, further supports the immune-mediated nature of this entity. Indeed, atrial-fibrillation may be caused by an immune-mediated mechanism [16], and melanonychia is known to be associated with immune-mediated disorders [17]. Interestingly, the baby from patient 1 developed neonatal normal GGT cholestasis that spontaneously resolved within 4 months.…”

A Case of Poliosis Caused by Halo Nevus

“…[3][4][5] Poliozis ile ilişkili diğer tablolar arasında Marfan sendromu, Vogt-Koyanagi-Harada sendromu, Alezzandrini sendromu, Rubinstein-Taybi sendromu, Waardenburg sendromu, nörofibromatozis, sarkoidoz, idiyopatik üveit, tüberöz skleroz, piebaldizm, alopesi areata, diskoid lupus eritematozus ve psöriyazis gibi çeşitli tablolar bulunmaktadır. [12][13][14][15] Poliozisin patogenezi tam olarak bilinmemektedir. Nevüsler ve melanom üzerinde gelişen poliozisin oluşumunda, T-hücre aracılı otoimmün yanıtın foliküler melanositlerin yıkılmasından sorumlu olduğu düşünülmektedir.…”

Diseases of the Hair and Nails

“…Systemic lupus erythematosus can cause anagen arrest and anagen hair loss, although diffuse telogen hair loss is usually more frequent. 10 The form of chronic cutaneous lupus, discoid lupus erythematosus, causes a scarring type of hair loss 39 and features of systemic lupus erythematosus are not usually present. Scarring alopecias are characterized by the loss of visible follicular openings and destruction to the regenerative stem cells in the bulge area of the hair follicle.…”