Hair Loss and the Applied Techniques for Identification of Novel Hair Growth Promoters for Hair Re-Growth

Damodaran, Rajesh Guruswamy; Gupta, Ramkrishna

doi:10.5530/pj.2011.22.1

Cited by 8 publications

(10 citation statements)

References 19 publications

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“…e condition a ects both male and female but a ect males mostly because of the high levels of testosterone in males. Testing for the extract's e ect on androgenic alopecia will require other animal models like stump tailed macaque which develop similar scalp baldness due to the generation of androgens in its body [9,27].…”

Section: Determination Of Hair Lengthmentioning

confidence: 99%

“…Oral finasteride worked effectively against male pattern baldness. Few reports of mild sexual related problems such as irregular ejaculation, lower sperm volume, and poor sexual performance which normally subside upon discontinuation of treatment were observed on clinical trials [8,9]. Considering that both finasteride (a dihydrotestosterone-suppressing 5a-reductase inhibitor) and minoxidil (an antihypertensive potassium channel opener) are products of serendipity [6], more focus should be given in an attempt to design drugs of specific pharmacological action against hair loss.…”

Section: Introductionmentioning

confidence: 99%

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Hair Growth Promoting Effect of Dicerocaryum senecioides Phytochemicals

Rambwawasvika

Dzomba

Gwatidzo

2019

International Journal of Medicinal Chemistry

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Phytochemicals from Dicerocaryum senecioides were studied for hair rejuvenation activity using BalB/c mice. Solvent extractions and thin layer chromatography (TLC) were used to extract and isolate the phytochemicals respectively. Phytochemicals were identi ed by spraying with target-speci c revealing reagents. In vivo hair growth stimulating activity for each extract was tested on denuded dorsal skin of 5-week old BalB/c mice against the controls and the standard drug minoxidil. e parameters used to evaluate hair growth were hair growth completion time, hair length, hair weight, hair follicle length, and relative hair follicle area. e identi ed phytochemicals from the active ethanol extract were steroidal glycosides, triterpenoid glycosides, and avonoid glycosides. Flavonoid glycosides treatment had the uppermost hair rejuvenation capacity as measured by the shortest hair growth completion time (19 days) versus control (29 days) and longest hair length (11.04 mm and 11.86 mm for male and female mice respectively while the control group had 5.15 mm for male mice and 5.33 mm for female mice). Hair growth stimulation by avonoid glycosides was also dependent on dose concentration. It can be concluded from this study that avonoid glycosides extracted from the leaves of Dicerocaryum senecioides have remarkable hair rejuvenation capacity in BalB/c mice. e present results provides insights on the use of Dicerocaryum senecioides for hair rejuvenation in traditional practices and on the potential of the plant as a source of novel compounds that can be used as hair growth promoters.

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Section: Determination Of Hair Lengthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hair Growth Promoting Effect of Dicerocaryum senecioides Phytochemicals

Rambwawasvika

Dzomba

Gwatidzo

2019

International Journal of Medicinal Chemistry

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“…To test the in vivo effects of Ea and Ec extract, we took advantage of the short hair cycle of beard hair of less than one year [27]. By observing the hair follicles of the participants on an annual basis, we calculated the yearly increase of hair cycle‐associated greying.…”

Section: Resultsmentioning

confidence: 99%

Eriodictyonangustifolium extract, but not Eriodictyon californicum extract, reduces human hair greying

Taguchi

Hata

Kamiya

et al. 2020

Intern J of Cosmetic Sci

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OBJECTIVE: Yerba Santa (Eriodictyon angustifolium and Eriodictyon californicum) has been used for many years in traditional medicine. However, the effect of Yerba Santa on melanogenesis has not yet been investigated. We aimed to assess the biological effects of Yerba Santa on hair pigmentation. METHODS: Yerba Santa extracts were assessed for their cytological effects following X-ray irradiation treatment and then tested directly for the prevention of human hair greying. Ultra-performance liquid chromatography (UPLC) was utilized to identify the individual extract components. RESULTS: Eriodictyon angustifolium extract significantly increased melanin synthesis in the melanoma cell line through activation of the WNT/MITF/tyrosinase-signalling pathway. In contrast, E. californicum had no effect on melanin synthesis. E. angustifolium extract also demonstrated a protective effect against the damage induced by X-ray irradiation in human keratinocytes. Application of the extracts to subjects who had grey beards demonstrated a reduced number of grey beard hair per year specifically with the E. angustifolium extract. A significant decrease in grey head hair was also observed after application of E. angustifolium extract. Upregulation of gene expression related to melanin production and WNT signalling was observed after the application of E. angustifolium extract. Sterubin was the most abundant flavonoid detected by UPLC in E. angustifolium extract. In addition, sterubin showed the highest difference in terms of quantity, between E. angustifolium and E. californicum extract. CONCLUSION: Eriodictyon angustifolium extract, which is abundant in sterubin, may be suitable as a potential cosmetic and medical agent for the prevention and improvement of hair greying. et E. californicum. CONCLUSION: L'extrait d'E. angustifolium, qui est abondant en st erubine, peut convenir comme agent cosm etique et m edical potentiel pour la pr evention et l'am elioration du grisonnement des cheveux.

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“…In humans, the main function of the hair is mainly related to appearance [1]. Various factors like genetic predisposition and hormonal factors have predominantly contributed to the major reason of hair fall [2].…”

Section: Introductionmentioning

confidence: 99%

Hair Growth Activity of Seeds and Fruit Pulp of Eugenia jambolana (Jamun)

Gupta

2015

PPIJ

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Preparation of formulation:The ethanolic extracts were incorporated into hair cream base for the preparation of ointment by using fusion method with o/w base [12]. The ointment base consisted of white soft paraffin (90%), cetosteryl alcohol (5%), bees wax (20%) and hard paraffin (3%). Research ArticlePharm Pharmacol Int J 2015, 2(6): 00039 AbstractObjective: Alopecia is a psychologically distressing condition. Androgenetic alopecia, which affects millions of men and women, is an androgen-driven disorder. This paper evaluates the use of Eugenia jambolana seeds and fruit pulp for hair growth activity.Aim: The present study was aimed to investigate the efficacy of seeds and pulp extracts of Eugenia jambolana as a potential hair growth promoter.Method: Ethanolic extracts of seeds and fruit pulp were incorporated in oleaginous base that was applied topically on shaved skin of albino mice. Albino mice were screened for hair growth activity, on four parameters; the hair initiation time, hair completion time, hair length and hair count. Treated groups were compared with 2% ethanolic solution of minoxidil.Result: From this study, it can be concluded that the ethanolic extract of fruit pulp exhibited more pronounced effects when compared to the seeds extract. Conclusion:The generated data proved that the Eugenia jambolana fruit pulp extract exhibit a significant potency in promoting hair growth.

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Hair Loss and the Applied Techniques for Identification of Novel Hair Growth Promoters for Hair Re-Growth

Cited by 8 publications

References 19 publications

Hair Growth Promoting Effect of Dicerocaryum senecioides Phytochemicals

Hair Growth Promoting Effect of Dicerocaryum senecioides Phytochemicals

Eriodictyonangustifolium extract, but not Eriodictyon californicum extract, reduces human hair greying

Hair Growth Activity of Seeds and Fruit Pulp of Eugenia jambolana (Jamun)

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