Hair Loss and Telogen Effluvium Related to COVID-19: The Potential Implication of Adipose-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma as Regenerative Strategies

Gentile, Pietro

doi:10.3390/ijms23169116

Cited by 23 publications

(19 citation statements)

References 73 publications

(135 reference statements)

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“…94 The use of MSCs and platelet-rich plasma has also been included in treatment studies for patients with hair loss caused by COVID-19 infection. 95 3.4. Pluripotent Stem Cells.…”

Section: Mechanical Properties Of the Substratementioning

confidence: 99%

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Innovative Approaches and Advances for Hair Follicle Regeneration

Zheng

2023

ACS Biomater. Sci. Eng.

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Pathological hair loss (also known as alopecia) and shortage of hair follicle (HF) donors have posed an urgent requirement for HF regeneration. With the revelation of mechanisms in tissue engineering, the proliferation of HFs in vitro has achieved more promising trust for the treatments of alopecia and other skin impairments. Theoretically, HF organoids have great potential to develop into native HFs and attachments such as sweat glands after transplantation. However, since the rich extracellular matrix (ECM) deficiency, the induction characteristics of skin-derived cells gradually fade away along with their trichogenic capacity after continuous cell passaging in vitro. Therefore, ECM-mimicking support is an essential prelude before HF transplantation is implemented. This review summarizes the status of providing various epidermal and dermal cells with a threedimensional (3D) scaffold to support the cell homeostasis and better mimic in vivo environments for the sake of HF regeneration. HF-relevant cells including dermal papilla cells (DPCs), hair follicle stem cells (HFSCs), and mesenchymal stem cells (MSCs) are able to be induced to form HF organoids in the vitro culture system. The niche microenvironment simulated by different forms of biomaterial scaffold can offer the cells a network of ordered growth environment to alleviate inductivity loss and promote the expression of functional proteins. The scaffolds often play the role of ECM substrates and bring about epithelial−mesenchymal interaction (EMI) through coculture to ensure the functional preservation of HF cells during in vitro passage. Functional HF organoids can be formed either before or after transplantation into the dermis layer. Here, we review and emphasize the importance of 3D culture in HF regeneration in vitro. Finally, the latest progress in treatment trials and critical analysis of the properties and benefits of different emerging biomaterials for HF regeneration along with the main challenges and prospects of HF regenerative approaches are discussed.

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“…94 The use of MSCs and platelet-rich plasma has also been included in treatment studies for patients with hair loss caused by COVID-19 infection. 95 3.4. Pluripotent Stem Cells.…”

Section: Mechanical Properties Of the Substratementioning

confidence: 99%

“…That indicates that MSCs could be DPC substitutes for the treatment of hair loss . The use of MSCs and platelet-rich plasma has also been included in treatment studies for patients with hair loss caused by COVID-19 infection …”

Section: Available Potential Cellsmentioning

confidence: 99%

Innovative Approaches and Advances for Hair Follicle Regeneration

Zheng

2023

ACS Biomater. Sci. Eng.

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“…Es un potente inhibidor del crecimiento del pelo, así Como de la diferenciación y proliferación de células de la matriz. Al igual que TNFα induce la fase catágena prematuramente, produce estrés oxidativo y promueve la apoptosis de células foliculares 17 …”

Section: Citocinas Proinflamatoriasunclassified

“…Los queratinocitos responden al estrés químico liberando IL 1, especies reactivas de oxígeno, prostaglandinas e histamina, los cuales potencialmente inhiben el crecimiento del pelo y la supervivencia del folículo. 17 …”

Section: Citocinas Proinflamatoriasunclassified

Efluvio telógeno inducido por COVID-19

Martínez Jiménez

2023

Piel

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“…Hair loss can be classified in several forms including male‐ or female‐androgenetic alopecia (AGA and FAGA, respectively), and telogen effluvium (TE). AGA is one of the most frequent hair loss causes, 1 affecting 50% of men by 50 years of age and nearly 50% of women 2 . This condition is characterized by hair follicular miniaturization.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3‐month, controlled, assessor‐blinded study

Milani

Colombo

2023

Skin Research and Technology

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Background: Oral supplementation with some amino acids (like methionine, taurine, and cysteine) could be useful in subjects with hair loss conditions such as androgenic alopecia (AGA or FAGA) or telogen effluvium (TE). Hydrolysed collagen (HC) oral supplementation has demonstrated to have beneficial effects on nail and skin health and could improve hair growth. A food supplement in tablet formulation containing hydrolysed fish-origin collagen (300 mg/dose), taurine, cysteine, methionine, iron, and selenium has been recently available. To date no controlled data are available regarding the clinical efficacy of this product as adjuvant to hair loss specific treatments in these clinical conditions. Study aims:To evaluate and compare the efficacy and tolerability of an oral supplementation based on HC and amino acids in subjects with hair loss due to AGA/FAGA or chronic TE in combination with drug treatments in comparison with drug treatments alone. Methods and subjects:In a prospective, 12-week, randomized, assessor-blinded controlled trial 83 subjects (mean age 41 ± 16 years; 26 men and 57 women) were enrolled in the study. Fifty-nine subjects suffered from AGA/FAGA (Hamilton I-VA, Ludwig I-1, II-2) and 24 from chronic TE. Subjects were randomized to oral supplementation (1 tablet day) in combination with the specify drug treatment decided by the investigator according to the type of hair loss (AGA/FAGA or TE) (Group A; N = 48) or to specific drugs treatment only (Group B; N = 35). The main outcome of the trial wasThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Hair Loss and Telogen Effluvium Related to COVID-19: The Potential Implication of Adipose-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma as Regenerative Strategies

Cited by 23 publications

References 73 publications

Innovative Approaches and Advances for Hair Follicle Regeneration

Innovative Approaches and Advances for Hair Follicle Regeneration

Efluvio telógeno inducido por COVID-19

Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3‐month, controlled, assessor‐blinded study

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