Hair grows hair: Dual-effective hair regrowth through a hair enhanced dissolvable microneedle patch cooperated with the pure yellow light irradiation

Hong, Can; Zhang, Guoliang; Zhang, Wei; Liu, Jiaqi; Zhang, Jiao; Chen, Yutong; Peng, Haichuan; Cheng, Yuan; Ding, Xingwei; Xin, Hong‐Bo; Wang, Xiaolei

doi:10.1016/j.apmt.2021.101188

Cited by 18 publications

(14 citation statements)

References 29 publications

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“…Microneedles (MNs) with three-dimensional microstructures with microscale lengths (usually less than 1000 μm) are a potential direction, which can overcome the complex and dynamic barriers of the stratum corneum, control the delivery dose, and improve the efficiency and accuracy of drugs [ 16 , 18 ]. In recent years, microneedle drug delivery systems therapy for alopecia disease has received extensive attention and fueled the hair loss therapy research field [ 19 , 20 , 21 , 22 ]. However, individual differences have led to an ever-increasing need for precise hair growth.…”

Section: Introductionmentioning

confidence: 99%

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

et al. 2022

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Interest in transdermal delivery methods for stimulating hair regrowth has been increasing recently. The microneedle approach can break the barrier of the stratum corneum through puncture ability and improve drug delivery efficiency. Herein, we report a dissolvable microneedle device for the co-delivery of rapamycin and epigallocatechin gallate nanoparticles that can significantly promote hair regeneration. Compared with the mice without any treatment, our strategy can facilitate hair growth within 7 days. Higher hair shaft growth rate and hair follicle density with inconspicuous inflammation were exhibited in C57BL/6 mice, elucidating its potential for clinical application.

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Section: Introductionmentioning

confidence: 99%

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

et al. 2022

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“…Regarding delivery mechanism, a microneedle‐based transdermal drug delivery approach has been shown to have improved efficacy compared to subcutaneous injection or topical administration of exosomes 50 . Another group demonstrated that combination therapy of microneedle patches containing exosomes of human amniotic mesenchymal stem cells combined with low‐color‐temperature yellow light synergistically facilitated hair regrowth in 7 days compared to monotherapy 51 . Another treatment using DPC exosomes encapsulated in oxidized sodium alginate has shown promise 52 .…”

Section: Resultsmentioning

confidence: 99%

“…50 Another group demonstrated that combination therapy of microneedle patches containing exosomes of human amniotic mesenchymal stem cells combined with low-color-temperature yellow light synergistically facilitated hair regrowth in 7 days compared to monotherapy. 51 Another treatment using DPC exosomes encapsulated in oxidized sodium alginate has shown promise. 52 However, all such studies are conducted in animal models.…”

Section: Treatment Optimizationmentioning

confidence: 99%

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Kost

Muskat

Mhaimeed³

et al. 2022

J of Cosmetic Dermatology

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Background: Alopecia is a common chief complaint and is challenging to treat. As such, regenerative treatments to promote hair growth are an emerging area of research. Exosomes, which are extracellular vesicles involved in cell communication, homeostasis, differentiation, and organogenesis, have been shown to play a central role in hair morphogenesis and regeneration with potential for use as alopecia treatment.Aims: This review summarizes and assesses the body of literature surrounding exosomes as regenerative therapeutics for alopecia and identifies areas for improvement in future research.Methods: A review was conducted using a comprehensive list of keywords including "exosome," "alopecia," and "hair loss" on PubMed, EMBASE, and Google Scholar databases published from inception to February 2022. Reference lists of identified articles were included. 47 studies were included. Clinical trial databases were searched using the term "exosome"; however, no trials relevant to hair growth were identified.Results: Our updated and comprehensive review details the history of exosome use in medicine, postulated underlying mechanisms in treating hair loss, and current clinical studies. Preclinical studies demonstrate clear benefits of exosome therapeutics in regenerative medicine and for hair loss treatment. Clinical trials demonstrate safety of exosome use in medicine, but data showing efficacy and safety of exosome therapy for alopecia are lacking. We identified several gaps in knowledge required for effective clinical translation including safety, exosome source, and optimal treatment delivery mechanism and dosage. Conclusion:Exosomes are on the horizon as an exciting therapeutic for the treatment of alopecia. Further studies and clinical trials are required.

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“…When the MN patch was rehydrated, it could be dissolved and transformed into a gel (Figure S3C–D). Next, we explored the chemical composition of the HMPs, which were composed of melanin and keratin. , EDS analysis detected the three basic elements of carbon, oxygen, and nitrogen (C, O, and N) in the HMPs, while the signal of the sulfur (S) peak was attributed to the disulfide between peptide chains (Figure G). Then, the FTIR spectra of the HMPs and melanin were studied.…”

Section: Resultsmentioning

confidence: 99%

Hair Derived Microneedle Patches for Both Diabetic Foot Ulcer Prevention and Healing

Zhang

Liu

et al. 2022

ACS Biomater. Sci. Eng.

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The large amount of reactive oxygen species (ROS) produced by high glucose metabolism in diabetic patients not only induces inflammation but also damages blood vessels, finally resulting in low limb temperature, and the high glucose environment in diabetic patients also makes them susceptible to bacterial infection. Therefore, diabetic foot ulcer (DFU) usually presents as a nonhealing wound. To efficaciously prevent and treat DFU, we proposed a near-infrared (NIR) responsive microneedle (MN) patch hierarchical microparticle (HMP)-ZnO-MN-vascular endothelial growth factor and basic fibroblast growth factor (H-Z-MN-VEGF&bFGF), which could deliver drugs to the limbs painlessly, accurately, and controllably under NIR irradiation. Therein, the hair-derived HMPs exhibited the capacity of scavenging ROS, thereby preventing damage to the blood vessels. Meanwhile, zinc oxide (ZnO) nanoparticles endowed the MN patch with excellent antibacterial activity which could be further enhanced with the photothermal effect of HMPs under NIR irradiation. Moreover, vascular endothelial growth factor and basic fibroblast growth factor could promote the angiogenesis. A series of experiments proved that the MN patch exhibited broad-spectrum antibacterial and anti-inflammatory capacities. In vivo, it obviously increased the temperature of fingertips in diabetic rats as well as promoted collagen deposition and angiogenesis during wound healing. In conclusion, this therapeutic platform provides a promising method for the prevention and treatment of DFU.

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Hair grows hair: Dual-effective hair regrowth through a hair enhanced dissolvable microneedle patch cooperated with the pure yellow light irradiation

Cited by 18 publications

References 29 publications

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

Hair Derived Microneedle Patches for Both Diabetic Foot Ulcer Prevention and Healing

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