Hair graying and loss induced by imatinib mesylate

Yun, Seok Kweon; Song, Ki Hun; Hwang, Su Ran; Kim, Han Uk; Lee, Na Ri; Park, Jin

doi:10.1111/1346-8138.12342

Cited by 8 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Imatinib inhibits BCR-ABL, PDGFR, and c-kit. Both hair depigmentation (lightening) [28,29] and hair darkening (repigmentation of grey hair) [30,31] have been reported during imatinib treatment at a dosage of 300-800 mg daily, with onset occurring after a median time of four weeks (range: 1-14 months) following treatment initiation. In the majority of cases, the pigmentary abnormalities were reversible after dose reduction or drug withdrawal.…”

Section: Imatinibmentioning

confidence: 99%

Drug-induced hair colour changes

Ricci¹,

Simone²,

Regno³

et al. 2016

European Journal of Dermatology

View full text Add to dashboard Cite

Drug-induced hair colour changesHair colour modifications comprise lightening/greying, darkening, or even a complete hair colour change, which may involve the scalp and/or all body hair. Systemic medications may cause hair loss or hypertrichosis, while hair colour change is an uncommon adverse effect. The rapidly increasing use of new target therapies will make the observation of these side effects more frequent. A clear relationship between drug intake and hair colour modification may be difficult to demonstrate and the underlying mechanisms of hair changes are often unknown. To assess whether a side effect is determined by a specific drug, different algorithms or scores (e.g. Naranjo, Karch, Kramer, and Begaud) have been developed. The knowledge of previous similar reports on drug reactions is a key point of most algorithms, therefore all adverse events should be recognised and reported to the scientific community. Furthermore, even if hair colour change is not a life-threatening side effect, it is of deep concern for patient's quality of life and adherence to treatment. We performed a review of the literature on systemic drugs which may induce changes in hair colour.

show abstract

Section: Imatinibmentioning

confidence: 99%

Drug-induced hair colour changes

Ricci¹,

Simone²,

Regno³

et al. 2016

European Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Dermatologic side effects like skin rash, dermatitis, and pruritus are common in patients treated with imatinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST) . However, hair‐related side effects like graying and hair loss are rare . Here we report a female patient, after 6 months of imatinib ingestion, who experienced patchy hair loss with broken hair, hair depigmentation, and thinning, and discuss the possible mechanism.…”

mentioning

confidence: 95%

“…Hair graying and mild hair loss in patients undergoing imatinib therapy was reported by a few authors . The mechanism of hair graying is related to inhibition of stem cell factor (SCF) and its receptor c‐kit (CD117), which are responsible for survival, differentiation, and proliferation of the melanocyte .…”

mentioning

confidence: 99%

Hair loss associated with imatinib treatment: a dermoscopic study

2017

View full text Add to dashboard Cite

Acquired Disorders of Hair

Harries,

Holmes,

McMichael

et al. 2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

This chapter reviews acquired hair disorders, including common scarring and non‐scarring alopecia presentations, conditions characterised by excessive body hair growth and acquired hair shaft disorders. We also describe the biology of normal hair follicles, including structure, hair cycle control and immunity, to better understand the mechanisms underlying these conditions. We present methods for clinical assessment, recommended investigation and management of each disease, and present summaries of frequently used therapeutics and cosmetic options employed when treating these problems.

show abstract

Hair graying and loss induced by imatinib mesylate

Cited by 8 publications

References 4 publications

Drug-induced hair colour changes

Drug-induced hair colour changes

Hair loss associated with imatinib treatment: a dermoscopic study

Acquired Disorders of Hair

Contact Info

Product

Resources

About