Hair Follicle Targeting and Dermal Drug Delivery with Curcumin Drug Nanocrystals—Essential Influence of Excipients

Pelikh, Olga; Keck, Cornelia M.

doi:10.3390/nano10112323

Cited by 35 publications

(43 citation statements)

References 54 publications

(75 reference statements)

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“…This leads to a longer maintenance of the aqueous meniscus between particle and skin and to a more pronounced local swelling of the SC. Thus, this promotes the passive dermal penetration of curcumin when compared to pure water [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…The fluorescence images (200-fold magnification) were subjected to digital image analysis with ImageJ software [ 47 , 48 ] to determine the mean penetration depth (MPD) of curcumin and the mean gray value (MGV) as a surrogate for the total amount of penetrated curcumin into and through the skin [ 27 , 37 , 49 ]. A possible swelling of the stratum corneum (SC) was also investigated by determining the mean SC thickness.…”

Section: Methodsmentioning

confidence: 99%

“…After the elimination of the skin autofluorescence (class II pixel), the remaining light intensity within the image corresponds to curcumin in the skin biopsy (class I pixel). Consequently, the measured MGV value can be used as a surrogate for the total amount of penetrated curcumin into the skin [ 27 , 37 , 49 ].…”

Section: Methodsmentioning

confidence: 99%

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Improved Dermal and Transdermal Delivery of Curcumin with SmartFilms and Nanocrystals

2021

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Poor aqueous solubility of active compounds is a major issue in today’s drug delivery. In this study, the smartFilm technology was exploited to improve the dermal penetration efficacy of a poorly soluble active compound (curcumin). Results were compared to the dermal penetration efficacy of curcumin from curcumin bulk suspensions and nanocrystals, respectively. The smartFilms enabled an effective dermal and transdermal penetration of curcumin, whereas curcumin bulk- and nanosuspensions were less efficient when the curcumin content was similar to the curcumin content in the smartFilms. Interestingly, it was found that increasing numbers of The effect is caused by an aqueous meniscus that is created between particle and skin if the dispersion medium evaporates. The connecting liquid meniscus causes a local swelling of the curcumin particles within the suspensions increased the passive dermal penetration of curcumin. stratum corneum and maintains a high local concentration gradient between drug particles and skin. This leads to a high local passive dermal penetration of curcumin. The findings suggest a new dermal penetration mechanism for active compounds from nanoparticulate drug delivery systems, which can be the base for the development of topical drug products with improved penetration efficacy in the future.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Improved Dermal and Transdermal Delivery of Curcumin with SmartFilms and Nanocrystals

2021

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“…The formulation contained no water. Hence, the increase is due to occlusion, i.e., the water in the skin was prevented from evaporating, thus causing the SC to swell [36,37]. The ME, NE, and NLC increased the relative SCT to about 175%.…”

Section: Dermal Penetration Efficacymentioning

confidence: 99%

Are lipid nanoparticles really superior? A holistic proof of concept study

Wiemann

Keck

2021

Drug Deliv. and Transl. Res.

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Lipid nanoparticles are a successful carrier system for dermal drug delivery. They possess various beneficial properties, i.e., increased chemical stability for chemically labile compounds, increased dermal penetration of active compounds, or skin carrying properties after dermal application due to the formation of a so-called “invisible patch.” Despite manifold studies showing these properties individually, a study that investigates if one lipid nanoparticle formulation can really combine all the above-mentioned benefits at once is not yet available. In the present study, lipid nanoparticles (NLC) were produced and characterized regarding their physico-chemical properties. The chemical stability of the incorporated active ingredient (AI) was determined, as well as the dermal penetration efficacy of the AI, and the skin carrying properties of the NLC after dermal penetration. The properties of the NLC were compared to classical formulations, i.e., AI dissolved in pure oil, an o/w cream base and a nanoemulsion. All formulations contained similar lipids and emulsifiers, which allowed for a direct comparison of the different properties. NLC were shown to provide most efficient chemical stabilization and most efficient dermal penetration for the AI. The formation of the invisible patch was shown for the NLC but not for the other formulations. Skin hydration and skin carrying properties were also most pronounced for the NLC. Results provide evidence that NLC can combine all beneficial effects that were previously described in one formulation. Thus, providing evidence that NLC are a holistically superior formulation principle when compared to other formulation principles. Graphical abstract

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“…To maximize the binding of the proteins to the hair fiber, their penetration into the hair cortex and the curling effect, the proteins were incorporated into a phosphate buffer with different pH values (5, 7 and 9). To promote the swelling of the hair fibers and the lifting of the cuticles [29,30], the hair tresses were pretreated with an urea solution followed by the ethanolic formulation prepared at pH 5, 7 and 9 prior to treatment with the proteins. To curl and fix the new shape, the hair tresses were thermally treated using a hot BaByliss for 50 s.…”

Section: Perming Efficiencymentioning

confidence: 99%

Proteins as Hair Styling Agents

et al. 2021

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The perming of hair is a common styling procedure with negative impact on the overall properties of the hair fibers. Usually, this process uses harsh chemicals to promote the disruption of disulfide bonds and the formation of new bonds to change the shape of hair. Here, we explored bovine serum albumin (BSA), silk fibroin (SF), keratin and two fusion recombinant proteins (KP-UM and KP-Cryst) as new perming agents. A phosphate buffer prepared at different pH values (5, 7 and 9) was used to apply the proteins to virgin Asian hair, and a hot BaByliss was used to curl the hair fibers. To assess the potential of the protein formulations for hair styling, the perming efficiency and the perming resistance to wash were measured. Furthermore, the fiber water content was evaluated to assess if the proteins protected the hair during the styling process. Despite all of the proteins being able to assist in the curling of Asian hair, the best perming efficiency and perming resistance to wash results were observed for BSA and keratin. These proteins showed perming efficiency values close to that measured for a commercial perming product (chemical method), particularly at pH 5 and 9. The increase in the hair’s internal and external water contents revealed a protective effect provided by the proteins during the application of heat in the styling procedure. This study shows the potential of proteins to be used in the development of new eco-friendly hair styling products.

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Hair Follicle Targeting and Dermal Drug Delivery with Curcumin Drug Nanocrystals—Essential Influence of Excipients

Cited by 35 publications

References 54 publications

Improved Dermal and Transdermal Delivery of Curcumin with SmartFilms and Nanocrystals

Improved Dermal and Transdermal Delivery of Curcumin with SmartFilms and Nanocrystals

Are lipid nanoparticles really superior? A holistic proof of concept study

Proteins as Hair Styling Agents

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