Hair follicle plasticity with complemented immune-modulation following follicular unit extraction

Azar, Reza P.; Thomas, Alexander; Lindner, G

doi:10.4103/0974-7753.153451

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…The hair follicles transplanted from the occipital to the frontal region exhibited the most noticeable reduction in length. Still, this diminution of FUs was irrespective of the follicle region of origin [20] . In the study in our hands, the post-transplantation changes were examined after 10 to 14 months of FUE.…”

Section: Discussionmentioning

confidence: 85%

Evaluation of Morphological and Histological Changes in Transplanted Hair Follicles

Khalil,

El Mofty,

Nasef

et al. 2023

International Journal of Medical Arts

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Article informationBackground: For the management of extensive loss of hair, the follicular unit extraction technique [FUE] procedure for hair transplantation is a popular operative operation. The Aim of the work:The goal of this investigation was to evaluate the morphological and histological changes in the transplanted hair follicles [HFs] after FUE for cases of androgenetic alopecia [AGA].Patients and Methods: It's a prospective interventional study that was carried out at Al Azhar University Hospitals between May 2018 and May 2023. In this investigation, 15 patients, ages 25 to 60, who were candidates for FUE hair transplantation and suffered from androgenetic alopecia were included.After 10-14 months following the procedure, the morphological and histological alterations in the transplanted FUs were contrasted with those of the native donor follicles. Results: There was a substantial variation [p-value = 0.002] between the donor and recipient sites regarding sebaceous gland degeneration. The donor site in all studied patients [100%] had no Arrector pili muscle degeneration while at recipient site, there were 5 patients [33.3%] with no Arrector pili muscle degeneration, four patients [26.7%] with [+] Arrector pili muscle degeneration, four patients [26.7%] with [++] Arrector pili muscle degeneration and two patients [13.3%] with [+++] Arrector pili muscle degeneration. Regarding outer root sheath degeneration, this data demonstrates a very substantial variation [p-value < 0.001] between the donor and recipient sites. Regarding inner root sheath degeneration, this data demonstrates a very substantial variation [p-value < 0.001] between the donor and recipient sites. Conclusion:The effect of the FUE procedure on the transplanted follicles is obvious morphologically and histologically, so it needs more interest, especially in the long run.

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Section: Discussionmentioning

confidence: 85%

Evaluation of Morphological and Histological Changes in Transplanted Hair Follicles

Khalil,

El Mofty,

Nasef

et al. 2023

International Journal of Medical Arts

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Hair Transplantation in Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

et al. 2020

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Objective: Evolving hair transplantation (HT) techniques have offered new possibilities for hair restoration. However, the role of HT in patients with frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP) remains unclear. This study aims to evaluate the outcomes and temporal relationship of HT in this population. Methods: A literature search of three databases was conducted. We reviewed 1) literature reporting outcomes of patients with LPP or FFA who received HT, and 2) studies reporting the development of LPP or FFA resulting from HT. Results: Thirteen articles included 42 patients that provided data for evaluation. Fifteen patients had previously been diagnosed with FFA or LPP, and the remaining 27 patients developed disease after undergoing HT. Seven patients with FFA and eight patients with LPP received HT, with a mean sustained disease remission of 2.69 years prior to HT. In total, two of seven (29%) patients with FFA and five of eight (75%) patients with LPP experienced positive HT results over a follow‐up period of 8–72 months. Interestingly, 27 patients without evidence of previous disease developed FFA or LPP following HT after a median duration of 16 months. Conclusions: HT for LPP and FFA is feasible but results may be less favorable compared to HT for other causes. Outcomes may be more favorable for LPP than FFA but this was not statistically significant and evidence is very limited. FFA and LPP can also develop following HT in patients without previous evidence of disease. Level of Evidence: NA Laryngoscope, 131:59–66, 2021

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Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation

Azar

Thomas

Maurer

et al. 2016

The American Journal of Dermatopathology

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Follicular unit transplantation is the most commonly performed technique in modern restorative hair transplantation surgery. It relies on the acquisition of intact follicular units from microdissected scalp skin strips and their subsequent transplantation into the recipient regions affected by alopecia. Ideally, the translocation of follicular units from the balding-resistant areas of the scalp (usually the occipital region) to the recipient site should not result in any morphological change in the grafts. Nevertheless, the insults associated with surgical intervention present grafted follicles to mechanical and chemical cues differently from those of the physiological steady-state conditions in undamaged skin. This disruption of the normal follicular microenvironment might alter important aspects of hair biology in grafts, for example, hair cycle and pigmentation, and, in turn, could lead to differences in hair appearance, eventually culminating in a diminished esthetical outcome of the surgery. In this study, the authors analyzed native and grafted scalp hair follicles (HFs) from 2 patients who had undergone follicular unit transplantation surgeries formerly. Scanning electron microscopy and light microscopy-based histomorphometry revealed a marked enlargement of follicular structures in the grafts with a concomitant increase in hair shaft diameter. Immunohistological staining confirmed a thickening of the dermal sheath in transplanted HFs that also harbored a denser vascular network. Taken together, these results show that the grafted HFs analyzed were subjected to marked morphological changes during their residence in the recipient site and that this phenomenon is associated with a modulation of follicular vascularization.

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Hair follicle plasticity with complemented immune-modulation following follicular unit extraction

Cited by 5 publications

References 22 publications

Evaluation of Morphological and Histological Changes in Transplanted Hair Follicles

Evaluation of Morphological and Histological Changes in Transplanted Hair Follicles

Hair Transplantation in Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation

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