Hair-follicle dermal papilla and sheath fibroblasts provide a supportive microenvironment for human skin regeneration

Kaur, Pritinder

doi:10.1111/bjd.15474

Cited by 2 publications

(1 citation statement)

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“…102 Specialized dermal papilla (DP) and dermal sheath (DS) fibroblasts support hair follicles and differentiate from papillary precursors during embryonic development. Specific markers and gene expression signatures of DP have been described in both human and mouse skin, and they display several distinctive features 92,103 (Figure 2). DP fibroblasts have a high tendency to aggregate in culture and in tissues; in mouse dermis they provide a signaling niche for epithelial hair follicle stem cells.…”

Section: Fibroblast Heterogeneity In the Skinmentioning

confidence: 99%

A story of fibers and stress: Matrix‐embedded signals for fibroblast activation in the skin

Sawant

Hinz

Schönborn

et al. 2021

Wound Repair Regeneration

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Our skin is continuously exposed to mechanical challenge, including shear, stretch, and compression. The extracellular matrix of the dermis is perfectly suited to resist these challenges and maintain integrity of normal skin even upon large strains. Fibroblasts are the key cells that interpret mechanical and chemical cues in their environment to turnover matrix and maintain homeostasis in the skin of healthy adults. Upon tissue injury, fibroblasts and an exclusive selection of other cells become activated into myofibroblasts with the task to restore skin integrity by forming structurally imperfect but mechanically stable scar tissue. Failure of myofibroblasts to terminate their actions after successful repair or upon chronic inflammation results in dysregulated myofibroblast activities which can lead to hypertrophic scarring and/or skin fibrosis. After providing an overview on the major fibrillar matrix components in normal skin, we will interrogate the various origins of fibroblasts and myofibroblasts in the skin. We then examine the role of the matrix as signaling hub and how fibroblasts respond to mechanical matrix cues to restore order in the confusing environment of a healing wound.

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Section: Fibroblast Heterogeneity In the Skinmentioning

confidence: 99%