Hair follicle–containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial

Martínez, M.L. Martínez; Escario, Eduardo; Poblet, Enrique; Sanchez, David Martin; Buchón, Fernando-Francisco; Izeta, Ander; Jiménez, Francisco

doi:10.1016/j.jaad.2016.02.1161

Cited by 67 publications

(46 citation statements)

References 36 publications

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“…However, with yields and proliferation rates low, primary cells have obvious limitations, and do not always guarantee the desired outcome. In a randomized controlled study, autologous transplantation of terminal hair follicles using scalp punch grafts induced signifi cantly better healing of chronic venous leg ulcers than punch grafts harvested from nonhairy areas [ 88 ] . This might be explained by the fact that these areas include more hair follicle stem cells.…”

Section: Challenges and Perspectives In The Treatment Of Chronic Wounmentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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Summary The elderly constitute the age group most susceptible to wound healing disorders and chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic foot ulcers. However, other age‐associated diseases should also be taken into consideration in the diagnostic workup of chronic wounds, and not be underestimated. A better understanding of the pathomechanisms involved in the wound healing process is of key importance in combatting the difficulties associated with the treatment of chronic wounds. In recent decades, considerable progress has been made in the development of pioneering therapeutic strategies for chronic wounds. In this context, the use of growth factors and cytokines, tissue engineering, and cell therapy – including stem cells – have proven very promising. Nevertheless, prior to their introduction into routine clinical practice, large controlled clinical trials are required to assess the safety of these techniques.

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Section: Challenges and Perspectives In The Treatment Of Chronic Wounmentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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“…However, more recent evidence suggests their contribution to wound healing is temporary, and inevitably the cells disappear from the scar architecture once healed [110]. Because of their role in early wound healing, it is therefore not surprising that hair follicle stem cells may represent a reasonable method of autologous cell engraftment [111], but, like ASCs and BM-MSCs, require a surgery for procurement. Skin-derived precursor cells (SKPs) can also differentiate into glial, epidermal, and dermal cell types [112].…”

Section: Experimental Biomaterials and Future Directionsmentioning

confidence: 99%

“…In the case of keratinocytes, or hair follicle bulge cells, procurement of enough cell numbers to influence chronic or acute wound healing may be difficult. As such, even with autologous transplantation, it may be impossible to obtain adequate cell numbers to influence wound healing [66,103,111]. With rapid cultured expansion, other dermal stem cell precursors could be available as allogenic stem cell therapies [108,111,119].…”

Section: Experimental Biomaterials and Future Directionsmentioning

confidence: 99%

Minimizing Skin Scarring through Biomaterial Design

Moore

Longaker

2017

JFB

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Wound healing continues to be a major burden to patients, though research in the field has expanded significantly. Due to an aging population and increasing comorbid conditions, the cost of chronic wounds is expected to increase for patients and the U.S. healthcare system alike. With this knowledge, the number of engineered products to facilitate wound healing has also increased dramatically, with some already in clinical use. In this review, the major biomaterials used to facilitate skin wound healing will be examined, with particular attention allocated to the science behind their development. Experimental therapies will also be evaluated.

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“…Hemos probado nuestra técnica en un ensayo clínico aleatorizado realizado en pacientes con úlceras crónicas de la pierna (Martínez et al 2016). …”

Section: Estado Actual De Nuestro Sistemaunclassified

Procesamiento Automatizado De Modelos Tridimensionales De Úlceras Cutáneas

Sánchez-Jiménez¹,

Buchón-Moragues²,

Palomar-Vázquez³

et al. 2017

Proceedings - 1st Congress in Geomatics Engineering - CIGeo

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Abstract:Geomatics includes techniques such as photogrammetry, remote sensing and geographic information systems, which provide applicable tools in various areas of biomedicine, for example skin ulcer measurement. In previous projects we developed procedures for acquiring data and measuring skin ulcers using a digital photo camera, a manual scanner and photogrammetry software based on correlation. We have tested our technique in a randomized clinical trial in patients with chronic leg ulcers. In the present project an application system is created with the following objectives: automate the processing of three-dimensional models of cutaneous ulcers and generate documentation that ease the interpretation of the evolution of skin ulcers by medical personnel (including PDF report, AVI animation and XOS augmented reality project). We also created a website prototype that stores the documentation, allowing registered users to upload photographs and consult or modify the database of skin ulcers. A test is performed with 50 cutaneous leg ulcers, in order to debug and improve the application system and the website prototype.Key words: Skin ulcers, Wounds, 3D Modelling, Geomatics, Photogrammetry Resumen:La geomática utiliza técnicas como la fotogrametría, teledetección y sistemas de información geográfica, que proporcionan herramientas aplicables a diversas áreas de la biomedicina como, por ejemplo, la medición de úlceras cutáneas. En proyectos anteriores desarrollamos los procedimientos de toma de datos y medición de las dimensiones de las úlceras mediante cámara fotográfica digital, escáner manual y software fotogramétrico de escaneado basado en correlación. Hemos probado nuestra técnica en un ensayo clínico aleatorizado realizado en pacientes con úlceras crónicas de la pierna. En el presente proyecto se crea un sistema de aplicaciones con los siguientes objetivos: automatizar el procesamiento de los modelos tridimensionales de las úlceras cutáneas; generar una documentación que facilite la interpretación de la evolución de la úlcera cutánea por personal médico (incluyendo informe PDF, animación AVI y proyecto de realidad aumentada XOS). También se crea un prototipo de página web que almacene la documentación, permita subir fotografías y consultar o modificar la base de datos de úlceras cutáneas. Se realiza una prueba con datos de 50 úlceras cutáneas de pierna, para depurar y mejorar el sistema de aplicaciones y el prototipo de página web.

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Hair follicle–containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial

Cited by 67 publications

References 36 publications

Pathogenesis of wound healing disorders in the elderly

Pathogenesis of wound healing disorders in the elderly

Minimizing Skin Scarring through Biomaterial Design

Procesamiento Automatizado De Modelos Tridimensionales De Úlceras Cutáneas

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