Hair EDX Analysis—A Promising Tool for Micronutrient Status Evaluation of Patients with IBD?

Gîlcă-Blanariu, Georgiana-Emmanuela; Coroabă, Adina; Ciocoiu, Manuela; Trifan, Anca; Dimofte, Gabriel; Diaconescu, Smaranda; Afrăsânie, Vlad-Adrian; Balan, Gheorghe G.; Pinteală, Tudor; Ştefănescu, Gabriela

doi:10.3390/nu13082572

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…As we know, the accurate determination of trace elements in bone tissue mainly includes flame atomic absorption spectrometry (FAAS), inductively coupled plasma–mass spectrometry (ICP-MS), and EDX. 15–17 The bone tissue measured by the first two methods is incomplete because atomic absorption spectrometry (AAS) and ICP-MS require the removal of collagen, fat, bone marrow, and other components of bone samples through combustion or solvent dissolution, which may cause the loss of some trace elements. EDX is characterized by nondestructive sample analysis with the minimum amount of sample preparation, and samples can be detected under atmospheric pressure or in a low vacuum environment by polishing the sample surface.…”

Section: Discussionmentioning

confidence: 99%

Association between bone trace elements and osteoporosis in older adults: a cross-sectional study

Lin

Yang

Ling

et al. 2022

Therapeutic Advances in Musculoskeletal

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Objectives: Metal micronutrients deficiency may be one of the risk factors for the development of osteoporosis. This study aimed to measure the trace element contents in human bone tissue to analyze the relationship between micronutrients and osteoporosis. Design: A cross-sectional survey was performed on data from 51 elderly patients with proximal femoral fracture. Methods: The concentrations of calcium, phosphorus, manganese, iron, copper, and zinc in bone tissue samples from 51 elderly patients with proximal femoral fracture were determined by energy-dispersive X-ray fluorescence (EDX). Subjects were divided into osteoporosis and non-osteoporosis groups according to their bone mineral density (BMD) T-score values. The difference in metal elements concentrations in bone tissue between the two groups was compared, and the role of metal elements in osteoporosis was discussed. Results: There was no statistical difference in age, sex, body mass index (BMI), serum albumin, biochemical blood indices, and bone turnover markers between the two groups. The Mann–Whitney U test was used to compare the difference in metal elements concentrations in bone tissue samples between the two groups. The results showed that manganese, copper, and zinc concentrations in the cancellous bone were significantly higher in the non-osteoporosis group than in the osteoporosis group. Multivariate logistic regression analysis indicated that high bone zinc concentration [odds ratio = 0.26, 95% confidence interval (CI) = 0.075–0.928, p = 0.038] was negatively correlated with osteoporosis. Conclusion: Manganese, copper, and zinc play an essential role in bone mineralization and metabolism. Among them, zinc may be most closely related to osteoporosis and play a key role in bone development and maintenance of bone mass. Therefore, we believe that the design of zinc-rich compounds or nutrients as a new complementary factor to increase the intake of zinc for the elderly could be able to prevent and intervene in the occurrence of osteoporosis in the early stage.

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Section: Discussionmentioning

confidence: 99%

Association between bone trace elements and osteoporosis in older adults: a cross-sectional study

Lin

Yang

Ling

et al. 2022

Therapeutic Advances in Musculoskeletal

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“…We have conducted an ancillary study derived from a single prospective center casecontrol study in which we evaluated the mineral and trace elements status among patients with inflammatory bowel disease (IBD) by measuring hair concentration using Scanning Electron Microscope (SEM) and Energy Dispersive X-ray spectroscopy (EDX), and we also investigated the relationship between the micronutrients' status, disease activity, and systemic inflammatory markers [10].…”

Section: Methodsmentioning

confidence: 99%

Magnesium—A Potential Key Player in Inflammatory Bowel Diseases?

et al. 2022

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The altered magnesium status in inflammatory bowel disease (IBD) patients may have a significant clinical imprint considering its role in cell signaling and genomic stability, as well as its involvement in IBD patients’ fatigue. Our study pioneers the investigation of magnesium hair concentration patterns in an adult population of IBD patients. The hair magnesium concentration in IBD patients is compared to healthy controls in order to identify correlations between the magnesium status and relevant parameters related to disease activity, psychological status, and sleep quality. We report a significantly lower hair magnesium concentration within the IBD group compared to healthy controls (95%CI: 0.006–0.062; p = 0.017) and lower levels in CD compared to UC (95%CI: −0.061–−0.002; p = 0.038). We identified a borderline statistical significance between the hair magnesium concentration and UC disease activity (95%CI; −0.679–0.008; p = 0.055) and a significantly lower magnesium concentration in patients who reported increased sleep latency (95%CI −0.65–−0.102; p = 0.011) or decreased sleep duration (95%CI −0.613–−0.041; p = 0.028). Our results advance several hypotheses with substantial clinical impact to be confirmed in future studies. Magnesium levels appear to be modified in IBD patients, which suggests it either plays a primary role in disease pathophysiology or a is result of the disease’s evolution. Magnesium could be used in predictive models for clinical/subclinical disease activity. Moreover, magnesium supplementation may improve IBD evolution and sleep quality for patients with a deficit of this mineral. However, confirmatory evidence-based studies are needed to generate specific dosing, time of supplementation, and optimum monitoring of magnesium status in IBD patients.

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“…Together with SEM, EDX can provide both qualitative and quantitative elemental analysis of samples as small as 1 nanometer in diameter. EDX analysis of hair has various applications in medicine, including detecting levels of micronutrients to assess the nutritional status in patients with inflammatory bowel disease 6 and identifying exposure to other heavy metals, such as nickel and molybdenum 7 …”

Section: Figurementioning

confidence: 99%