Hair cycle-specific expression of versican in human hair follicles

Soma, Tsutomu; Tajima, Masahiro; Kishimoto, Jiro

doi:10.1016/j.jdermsci.2005.03.010

Cited by 95 publications

(102 citation statements)

References 18 publications

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“…Consistent with this, we found that Asc 2-P induces expression of versican in human dermal papilla cells [4]. Versican is known as a target gene of canonical Wnt/b-catenin signaling pathway [5] and is suggested to play an important role in anagen induction and maintenance of the normal growing phase [6]. Versican promoter is known to be activated by nuclear accumulation of b-catenin which complexes with TCF transcription factors in vascular smooth muscle cells [7].…”

Section: To the Editorsupporting

confidence: 75%

Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

Sung¹,

Kwack²,

Kim

et al. 2008

Journal of Dermatological Science

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Section: To the Editorsupporting

confidence: 75%

Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

Sung¹,

Kwack²,

Kim

et al. 2008

Journal of Dermatological Science

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“…Hypertrophic wounds and cycling hair follicles are instances in which proliferation-induced apoptosis is avoided. Interestingly, versican expression is strongly increased in each of these locations (29,30). The shown antiapoptotic effects of versican may therefore be at least partially responsible for cell survival as a component of the microenvironment.…”

Section: Discussionmentioning

confidence: 99%

The Ability of Versican to Simultaneously Cause Apoptotic Resistance and Sensitivity

LaPierre

Lee

et al. 2007

Cancer Research

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Expression of the extracellular matrix proteoglycan versican is associated with more than 10 types of cancers, often being secreted by stromal cells in response to tumor signals. Previous work in our lab has shown that overexpression of the V1 versican isoform in cultured fibroblasts (V1 cells) increases both proliferation and apoptotic resistance. We show here that V1 cells induced tumor formation in nude mice and that, in keeping with previously shown apoptotic resistance, V1 cells have down-regulated Fas mRNA and protein levels. Unexpectedly, however, V1 cells were found to be sensitized to a wide range of cytotoxic agents. This combination of selective apoptotic resistance and sensitivity is often seen in cancer cells. V1 cells were also shown to have high resting levels of p53 and murine double minute-2 proteins, correlating with apoptotic sensitivity. Treatment with UV radiation induced p21 expression in vector-transfected cells but not in V1 cells. As p21 induces cell cycle arrest and inhibits apoptosis, its loss in V1 cells, coupled with high resting levels of proapoptotic p53, may be at least partially involved in their premature death following cytotoxic treatment. This study further supports the importance of versican in cancer cell biology and the complexity of apoptosis regulation. [Cancer Res 2007;67(10):4742-50]

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“…In vivo hair growth assays showed that GFP-positive cells could induce hair when grafted with epithelial cells, whereas GFP-negative cells grafted with epithelium did not [2]. Also, specific expression of versican in the dermal papilla of anagen hair follicles and apparent down-regulation of versican expression in dermal papilla of vellus-like hair follicles in balding scalp suggest that versican plays an important role in anagen induction and maintenance of the normal hair growing phase [3]. Recently, versican was identified as a target gene of Wnt signaling through the b-catenin pathway [4], which is sufficient to maintain anagenphase characteristics of dermal papilla cells [5].…”

Section: To the Editormentioning

confidence: 99%