Hair cortisol levels as a retrospective marker of hypothalamic–pituitary axis activity throughout pregnancy: Comparison to salivary cortisol

D’Anna-Hernandez, Kimberly; Ross, Randal G.; Natvig, Crystal; Laudenslager, Mark L.

doi:10.1016/j.physbeh.2011.02.041

Cited by 298 publications

(294 citation statements)

References 37 publications

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“…Consequently, a loss of the substances may occur by washout effects, for example, cosmetic treatment (permanent waving, dyeing), or leaching out caused by mechanical damages of the hair structure. 43,44 The washout was also observed by several others 9,19,21,45 but not by all 46,47 groups. Manenschijn et al 46 assumed that washout of steroids results from hair sample decontamination steps before analysis.…”

mentioning

confidence: 63%

“…[16][17][18] Various studies were concerned with the question whether this increased cortisol concentration is also detectable in hair. [19][20][21] Compared with control samples, the cortisol concentrations (measured by immunoassays) showed the highest values (40-50 pg/mg) in the proximal segments of hair samples correlated to the third trimester. Elevated cortisol concentrations were reported to be detectable up to 3 months after pregnancy.…”

Section: Introductionmentioning

confidence: 88%

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Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Krumbholz¹,

Anielski²,

Reisch

et al. 2013

Therapeutic Drug Monitoring

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Background: Endogenous corticosteroids and endocannabinoids are both known to be involved in stress adaption and anti-inflammatory and immuneregulatory effects. The application of hair as retrospective specimen for long-term recording of corticosteroids and its association with stress-induced biochemical alterations was intensively examined. Methods:To evaluate the stability and correlation of various parameters of the endocannabinoid and corticosteroid systems, a prospective study was carried out. Hair samples were collected monthly over a pregnancy cycle (sixth week of pregnancy to 9 weeks postpartum). By comparison of hair concentrations in particular segments (ie, grown in the same time span but collected at different times), an examination of analyte stability in hair was achieved. Additionally, the comparison of proximal segments provided on biochemical information that is independent of alteration due to physical instability. The detection limits of a validated procedure using solid-phase extraction cleanup and liquid chromatography-mass spectrometry proved to be suitable to identify the endogenous levels of cortisol (limits of detection = 1.6 pg/mg), cortisone (2.1 pg/mg), anandamide (AEA, 0.3 pg/mg), and 2-arachidonoylglycerol (15 pg/mg).Results: Corticosteroid concentrations in corresponding hair segments were found to be reduced with increasing hair age; an average decline of cortisol and cortisone by 50% in 4 months was estimated. Independently, an increase of cortisol and cortisone in proximal segments collected during pregnancy was confirmed, which is assumed to be stress related. Endocannabinoids proved to be by far more stable, as demonstrated by subsequent monthly collection of corresponding segments and there was hardly any washout of AEA detectable. Elevated hair concentrations of AEA and 2-arachidonoylglycerol were detected in the first-second trimester of pregnancy, which corresponds to negative correlations between AEA, cortisol, and cortisone.

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mentioning

confidence: 63%

Section: Introductionmentioning

confidence: 88%

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Krumbholz¹,

Anielski²,

Reisch

et al. 2013

Therapeutic Drug Monitoring

View full text Add to dashboard Cite

show abstract

“…In the past years, several laboratories have expanded hair analysis to measure long-term levels of cortisol and other steroid hormones (5,6,7,8,9,10). This has allowed researchers to investigate cortisol exposure over much longer periods of time (months to years) than previously possible with samples of blood, saliva or urine.…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of cortisol measurements in hair

Wester

Rossum

2015

European Journal of Endocrinology

171

141

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Cortisol measurements in blood, saliva and urine are frequently used to examine the hypothalamus-pituitary-adrenal (HPA) axis in clinical practice and in research. However, cortisol levels are subject to variations due to acute stress, the diurnal rhythm and pulsatile secretion. Cortisol measurements in body fluids are not always a reflection of long-term cortisol exposure. The analysis of cortisol in scalp hair is a relatively novel method to measure cumulative cortisol exposure over months up to years. Over the past years, hair cortisol concentrations (HCC) have been examined in association with a large number of somatic and mental health conditions. HCC can be used to evaluate disturbances of the HPA axis, including Cushing's syndrome, and to evaluate hydrocortisone treatment. Using HCC, retrospective timelines of cortisol exposure can be created which can be of value in diagnosing cyclic hypercortisolism. HCC have also been shown to increase with psychological stressors, including major life events, as well as physical stressors, such as endurance exercise and shift work. Initial studies show that HCC may be increased in depression, but decreased in general anxiety disorder. In posttraumatic stress disorder, changes in HCC seem to be dependent on the type of traumatic experience and the time since traumatization. Increased hair cortisol is consistently linked to obesity, metabolic syndrome and cardiovascular disease. Potentially, HCC could form a future marker for cardiovascular risk stratification, as well as serve as a treatment target.

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“…e Kirschbaum group used 25-50 mg in their rst publications [8] and 10-15 mg in their recent studies [10] while the Laudenslager group [3] used 50 mg.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, hair cortisol has become a topic of global interest as a biomarker of chronic stress [2]. An increasing body of evidence has shown that hair cortisol levels re ect systemic plasma levels of the hormone over time, allowing estimation of chronic stress, both psychological and physiological, as well as disorders of the hypothalamic-pituitaryadrenal axis, including Cushing syndrom and Addison's disease [2][3][4].…”

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confidence: 99%

Human hair cortisol analysis: Comparison of the internationally-reported ELISA methods

Albar¹,

Russell²,

Koren³

et al. 2013

CIM

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Purpose: Recently, hair cortisol has become a topic of global interest as a biomarker of chronic stress. Different research groups have been using different methods for extraction and analysis, making it difficult to compare results across studies. A critical examination of the reported analytical methods is important to facilitate standardization and allow for a uniform interpretation. Methods: This study qualitatively compared four published procedures from laboratories in Germany, the Netherlands, USA and Canada. Multiple aspects of their procedures were compared. Results: A major difference among the laboratories was the ELISA kit used: the Canadian laboratory used the kit from ALPCO Diagnostics (Salem, MA, USA), the American laboratory used the kit from DRG International (Springfield, NJ, USA), the German laboratory used the kit from DRG Instruments GmbH (Marburg, Germany), or IBL (Hamburg, Germany), and the Dutch used the kit from Salimetrics (Suffolk, UK). In addition, there are noted differences in hair mass used as well as washing and extraction procedures. The range of hair cortisol levels determined in healthy volunteers by the four groups was within 2.3-fold: Koren, 46.1 pg/mg; Van Rossum, 29.72 pg/mg; Kirschbaum, 20 pg/mg and Laudenslager ~ 27 pg/mg. Conclusions: The relative similarities in hair cortisol values in volunteers among the four laboratories should facilitate a quality assurance exchange program, as a necessary step toward clinical use of this novel test.

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Hair cortisol levels as a retrospective marker of hypothalamic–pituitary axis activity throughout pregnancy: Comparison to salivary cortisol

Cited by 298 publications

References 37 publications

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair

Clinical applications of cortisol measurements in hair

Human hair cortisol analysis: Comparison of the internationally-reported ELISA methods

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