Hair cortisol concentration and glycated hemoglobin in African American adults

Lehrer, H. Matthew; Dubois, Susan K.; Maslowsky, Julie; Steinhardt, M

doi:10.1016/j.psyneuen.2016.06.018

Cited by 26 publications

(23 citation statements)

References 48 publications

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“…Preliminary investigations have documented associations between higher hair cortisol and various indices of chronic stress, including chronic pain [26], long-term unemployment [27], self-reported perceived stress in pregnancy [28] and psychological conditions such as post-traumatic stress disorder [29]. Pertinent to the current examination, hair cortisol has been positively associated with BMI [24, 30, 31], waist circumference, waist-to-hip ratio (WHR) [32], metabolic syndrome [32], a history of cardiovascular disease [33] and glycemic control [34]. In fact, hair cortisol may predict acute myocardial infarction in men [35].…”

Section: Introductionmentioning

confidence: 99%

Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health

2019

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Animal models have shown that chronic stress increases cortisol, which contributes to overeating of highly palatable food, increased abdominal fat and lower cortisol reactivity. Few studies in humans have simultaneously examined these trajectories. We examined premenopausal women, either mothers of children with a diagnosis of an autism spectrum disorder ( n = 92) or mothers of neurotypical children ( n = 91). At baseline and 2-years, we assessed hair cortisol, metabolic health, and reward-based eating. We compared groups cross-sectionally and prospectively, accounting for BMI change. Caregivers, relative to controls, had lower cumulative hair cortisol at each time point, with no decreases over time. Caregivers also had stable levels of poor metabolic functioning and greater reward-based eating across both time points, and evidenced increased abdominal fat prospectively (all ps ≤.05), independent of change in BMI. This pattern of findings suggest that individuals under chronic stress, such as caregivers, would benefit from tailored interventions focusing on better regulation of stress and eating in tandem to prevent early onset of metabolic disease, regardless of weight status.

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Section: Introductionmentioning

confidence: 99%

Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health

2019

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“…A meta-analysis of 11 studies has corroborated the positive association of hair cortisol with systolic blood pressure, whereas the relationship with diastolic blood pressure was overall non-significant [68••]. Elevated hair cortisol levels have also been related to adverse metabolic blood markers such as cholesterol, triglycerides and glycated haemoglobin [91–93, 95], although associations were not significant in all cases [94]. Thus, the relationship of hair cortisol with lipids varied considerably across studies.…”

Section: Research Evidence For the Relationship Of Hair Cortisol Withmentioning

confidence: 99%

Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress

2019

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Purpose of Review This review focuses on the concentration of cortisol in human hair as a biomarker of chronic stress in cardiovascular disease (CVD). We outline the cardiovascular consequences of cortisol excess and provide a comprehensive overview of recent studies investigating the relationship of hair cortisol with CVD. In addition, clinical implications and limitations of the evidence are discussed, together with directions for future research. Recent Findings Hair cortisol may be a reliable biomarker of chronic stress since it provides quantification of total cortisol secreted into hair over several weeks. A growing body of evidence suggests that elevated hair cortisol levels are associated with both the incidence of CVD and poorer recovery and treatment outcomes. Moreover, increased hair cortisol concentration has been linked with established cardiometabolic risk factors for CVD including high blood pressure, diabetes, and adiposity. Summary Hair cortisol is a promising biomarker of chronic cortisol excess which may contribute to both the pathogenesis and prognosis of CVD. However, the current evidence relies on small-scale cross-sectional studies. Further research adopting longitudinal designs across larger samples of CVD patients and healthy participants is required to inform the development of novel evidence-based interventions.

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“…Hair samples were wrapped in foil and stored at room temperature until shipped to the University of Colorado Anschutz Medical Center for analysis. Hair was ground, cortisol was extracted, and then measured by immunoassay (Salimetrics, LLC, State College, PA) according to previously published methods with average intra and inter-assay CVs 2.7% and 13.3%, respectively (Hoffman, Mazzoni, Wagner, Laudenslager, & Ross, 2016;Lehrer, Dubois, Maslowsky, Laudenslager, & Steinhardt, 2016).…”

Section: Cortisol Stress Responsementioning

confidence: 99%

Impact of a nutritional supplement during gestation and early childhood on child salivary cortisol, hair cortisol, and telomere length at 4–6 years of age: a follow-up of a randomized controlled trial

Oaks

Adu‐Afarwuah

Kumordzie

et al. 2020

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Dysregulation of the stress response can occur early in life and may be affected by nutrition. Our objective was to evaluate the long-term effect of nutritional supplementation during gestation and early childhood on child cortisol and buccal telomere length (a marker of cellular aging) at 4-6 years of age. We conducted a follow-up study of children born to women who participated in a nutritional supplementation trial in Ghana. In one group, a lipid-based nutrient supplement (LNS) was provided to women during gestation and the first 6 months postpartum and to their infants from age 6 to 18 months. The control groups received either iron and folic acid (IFA) during gestation or multiple micronutrients during gestation and the first 6 months postpartum, with no infant supplementation. At age 4-6 years, we measured hair cortisol, buccal telomere length, and salivary cortisol before and after a stressor. Salivary cortisol was available for 364 children across all three trial arms and hair cortisol and telomere length were available for a subset of children (n ¼ 275 and 278, respectively) from the LNS and IFA groups. Telomere length, salivary cortisol, and hair cortisol did not differ by supplementation group. Overall, these findings suggest that nutritional supplementation given during gestation and early childhood does not have an effect on child stress response or chronic stress in children at 4-6 years.Trial registration: ClinicalTrials.gov Identifier NCT00970866. LAY SUMMARYThis study addressed a research gap about whether improved nutrition during pregnancy and early childhood impacts telomere length and cortisol in preschool children. There was no difference in child telomere length or cortisol between two trial arms of a nutritional supplementation trial that began during pregnancy. The research outcomes indicate lipid-based nutrient supplements, a relatively new form of supplementation, do not have an effect on markers of stress or cellular aging measured in later childhood. ARTICLE HISTORY

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Hair cortisol concentration and glycated hemoglobin in African American adults

Cited by 26 publications

References 48 publications

Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health

Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health

Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress

Impact of a nutritional supplement during gestation and early childhood on child salivary cortisol, hair cortisol, and telomere length at 4–6 years of age: a follow-up of a randomized controlled trial

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