Hair Cortisol Analysis: A Promising Biomarker of HPA Activation in Older Adults: Figure 1.

Wright, Kathy; Hickman, Ron Lee; Laudenslager, Mark L.

doi:10.1093/geront/gnu174

Cited by 81 publications

(62 citation statements)

References 37 publications

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“…However, an analysis of 654 participants in middle and old adulthood (aged 47-82 y) from the German cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) study 23 could not confirm an association between HCC and obesity after adjustment for confounding variables. In addition to these contrary findings, it should also be noted that HCC is unable to disentangle impaired dynamics of the diurnal cortisol secretion patterns and may be less appropriate to identify blunted cortisol reactions 24 .…”

Section: Discussionmentioning

confidence: 95%

Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-Age study

Ladwig

Schriever

Atasoy

et al. 2020

Sci Rep

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The study aimed to examine the sex specific association of obesity with cortisol metabolism in a sample of older community dwelling people. The cross-sectional analysis included 394 men and 375 women (aged 65-90 years) of the population-based KORA-Age study. Multivariable regression analyses were employed to examine the association between cortisol samples (serum and salivary samples of morning after awakening (M1), 30 min later (M2) and at late night (LNSC)). Obesity was calculated as waist-to-hip ratio (WHR) and body mass index (BMI). Cortisol levels were not significantly different between obesity measures except for elevated serum cortisol (P = 0.02) levels in individuals with a low WHR. Higher M1 levels were especially apparent in women with normal BMI. Serum cortisol levels were inversely related to WHR (P = 0.004) and CAR AUc was inversely associated with BMi (P = 0.007). Sex-stratified analytic models revealed that both obesity measures showed a non-linear association with cortisol diurnal pattern (M1/LNSC) in men. Impaired cortisol patterns emerged at both very ends of the body weight distribution. These findings do not support a cortisol driven obesity etiology in an older population and even point to an inverse association of body weight with cortisol levels. Differences of cortisol secretion patterns in generalized and abdominal fat distribution were marginal.

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Section: Discussionmentioning

confidence: 95%

Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-Age study

Ladwig

Schriever

Atasoy

et al. 2020

Sci Rep

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“…A new technique to obtain more relevant measures of chronic stress is to collect cortisol from hair samples. That approach, a proxy measure of the HPA axis activity over the previous months, evaluates chronic stress, which is less influenced by immediate variables, and may better capture parenting intervention effects not seen in the studies reviewed here [ 61 , 62 ]. The single study using this method found that parent-training intervention can reduce chronic cortisol levels [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of parenting interventions on child and caregiver cortisol levels: systematic review and meta-analysis

et al. 2020

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Background Nurturing care, in which children are raised in engaging and safe environments, may reduce child stress and shape hypothalamic-pituitary-adrenal axis functioning. Hence, parent-training programs may impact child cortisol levels, as well as behavioral, social and health outcomes. We conducted a systematic review of the impact of parent-training interventions on children’s and caregivers’ cortisol levels, and meta-analyzed the results. Methods In January 2020, searches in PubMed, LILACS, ERIC, Web of Science, Scielo, Scopus, PsycNET and POPLINE databases were conducted, and two independent researchers screened the results for eligible studies – randomized trials that assessed the impact of parent-training interventions on child or caregiver cortisol levels. Random effects were used to pool the estimates, separately for children and caregivers, and for children’s morning and evening cortisol levels, as well as change across the day. Results A total of 27 eligible studies were found. Data from 19 studies were extracted and included in the meta-analyses, with 18 estimates of child cortisol levels and 5 estimates for caregiver cortisol levels. The pooled effect size (standardized mean difference) for the effects of parent training programs on morning child cortisol was 0.01 (95%CI: − 0.14 to 0.16; I 2 : 47.5%), and for caregivers it was 0.04 (95%CI: − 0.22 to 0.30; I 2 : 0.0%). Similar null results were observed for child evening cortisol and for the slope between morning and evening child cortisol. No evidence of publication bias was found. Conclusion Existing evidence shows no effect of parent-training interventions on child or caregiver post-intervention cortisol. Researchers are encouraged to adopt standardized protocols to improve evaluation standards, to test for intervention effects on psychosocial outcomes that are theorized to mediate the effects on biomarkers, and to use additional biomarkers for chronic stress.

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“…Chronic psychosocial stress: Chronic stress has a detrimental impact on human health if allowed to persist indefinitely. An important physiological response to stress is the stimulation of the hypothalamic-pituitary-adrenal axis and release of cortisol [38]. Due to diurnal variation in cortisol release, measurement of cortisol levels in body fluids such as urine, blood and saliva may be fraught with inconsistencies [38].…”

Section: Current Hair Testing Applications In Medicinementioning

confidence: 99%

“…An important physiological response to stress is the stimulation of the hypothalamic-pituitary-adrenal axis and release of cortisol [38]. Due to diurnal variation in cortisol release, measurement of cortisol levels in body fluids such as urine, blood and saliva may be fraught with inconsistencies [38]. Hence, hair cortisol level measurement is now being used as a surrogate biomarker for chronic psychosocial stress [38,39].…”

Section: Current Hair Testing Applications In Medicinementioning

confidence: 99%

Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of ‘Omics-Based Approaches

Adeola¹,

Wyk²,

Arowolo³

et al. 2018

Keratin

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Minimally and noninvasive investigation of pathology and treatment monitoring is highly attractive in medicine. The use of human hair samples as a non-invasive testing substrate is potentially poised to improve diagnostic and forensic medicine. Hair has the unique ability to capture long-term information about health and disease in an individual as compared to urine and blood. Testing long hair offers a potential means of long-term monitoring of drug compliance, drug abuse, chronic alcohol abuse, and diagnostic biomarker discovery. Even though human hair is mostly composed of keratin and keratin-associated proteins, very little literature has been published on human hair proteomics. Emerging high throughput omics based techniques such as proteomics are increasingly improving our depth of knowledge about the diagnosis, prognosis and prediction of diseases globally. Although many aspects of the use of these novel molecular aids to improve disease diagnosis and patient management remains elusive; it is evident that these techniques have improved precision medicine tremendously. This chapter aims to discuss current plausible application of human hair omics-based approaches to the field of pathology, diagnostics and precision/individualized medicine.

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Hair Cortisol Analysis: A Promising Biomarker of HPA Activation in Older Adults: Figure 1.

Cited by 81 publications

References 37 publications

Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-Age study

Association of generalized and central obesity with serum and salivary cortisol secretion patterns in the elderly: findings from the cross sectional KORA-Age study

Effects of parenting interventions on child and caregiver cortisol levels: systematic review and meta-analysis

Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of ‘Omics-Based Approaches

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