Hair chromium content of women with gestational diabetes compared with nondiabetic pregnant women

Aharoni, Ariel; Tesler, B; Paltieli, Y.; Tal, J.; Dori, Zvi; Шарф, М

doi:10.1093/ajcn/55.1.104

Cited by 48 publications

(36 citation statements)

References 24 publications

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“…These studies used only hair chromium concentrations, and the problems with measurement mentioned in the Introduction of this article may apply to these data. One study examined hair chromium in women with gestational diabetes compared with women with normal glucose tolerance in pregnancy (18) and found lower hair chromium at the end of pregnancy in women with gestational diabetes. The low median serum concentrations in the present study were consistent with other data that showed lower chromium in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Serum chromium does not predict glucose tolerance in late pregnancy

Gunton

Hams

Hitchman

et al. 2001

The American Journal of Clinical Nutrition

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Background:Chromium is an essential element in human nutrition. Serum concentrations of chromium are not well characterized during pregnancy or in gestational diabetes mellitus. Objective: The objective of this study was to determine whether low plasma chromium concentrations (≤ 3 nmol/L) are associated with altered glucose, insulin, or lipid concentrations during pregnancy. Design: The study was conducted prospectively and took place at the medical obstetric clinic of a tertiary referral hospital. Seventy-nine women with abnormal results of a 50-g glucose challenge test in the third trimester of pregnancy were studied. All women had a formal 75-g oral-glucose-tolerance test, and fasting insulin, lipid, and chromium concentrations were determined. Chromium was measured by graphite furnace atomic absorption spectrometry. Results: The median chromium concentration was 2 nmol/L (95% CI: 0, 12). There were no significant differences in age, plasma glucose, insulin, lipids, calculated insulin resistance, or calculated ␤ cell function between women with normal and those with abnormal (≤ 3 nmol/L) chromium concentrations. Conclusions: Plasma chromium during pregnancy does not correlate with glucose intolerance, insulin resistance, or serum lipids. Plasma chromium concentrations may not accurately reflect tissue stores of chromium. Several trials showed a beneficial effect of chromium supplementation on glucose tolerance, insulin, and lipids. A method for assessing body chromium stores is required to allow further study.Am J Clin Nutr 2001;73:99-104.

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Section: Discussionmentioning

confidence: 99%

Serum chromium does not predict glucose tolerance in late pregnancy

Gunton

Hams

Hitchman

et al. 2001

The American Journal of Clinical Nutrition

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“…The use of human hair as a tool of choice for monitoring the exposure to heavy metals in man is linked with the availability of suitable analytical procedures, sensitive enough to quantify the content of the respective element in the biological specimen tested. Since concentration of metals in human hair reflects their mean level in human body during a period of 2-5 months (Aharoni and Tesler, 1992), its use is far from being the universal tool for monitoring longer exposures to environmental pollutants. Nail analysis becomes a useful alternative for longer exposure period ranging between 12 and 18 months (Suzuki et al, 1988;Wilhelm and Hafner, 1991;Hayashi et al, 1993;Chen et al, 1999;Were et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Monitoring exposure to heavy metals among children in Lake Victoria, Kenya: Environmental and fish matrix

Oyoo–Okoth

Admiraal

Osano

et al. 2010

Ecotoxicology and Environmental Safety

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Monitoring exposure to heavy metals among children in Lake Victoria, Kenya General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. b s t r a c tThis study used hair and nails to biomonitor heavy metals (Pb, Cd, Cr and Cu) from geological source and exposure through regular fish consumption among children in Lake Victoria, Kenya. Concentration of Pb and Cu in water reflected anthropogenic pathways, while Cd and Cr reflected accumulation from the catchment basin. Higher concentration of heavy metals in the nails samples than the hair samples suggested longer term exposure. The estimated intake of Cd and Cr from fish in one site associated with high concentration of the metals from geological source was appreciably above the respective recommended daily allowance, signifying possible health risks to humans. Significant correlations between Pb, Cd and Cu in hair, nails and heavy metals from fish consumed suggested fish consumption as possible pathway of heavy metals in humans. Possible health risks from heavy metals were likely due to consumption of higher quantities of fish and from geological basins.

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“…These results are similar to those found by other researchers. 4,5 If chromium has any role in gestational diabetes, it may be that it is a possible treatment but not a cause or correlation. It is possible that gestational diabetes is different from type 2 diabetes in regard to chromium.…”

Section: Discussionmentioning

confidence: 99%

“…One study looked at hair chromium concentration in relation to gestational diabetes. 4 It demonstrated that hair chromium concentration was significantly higher in patients with gestational diabetes and that the disease was not associated with low chromium status as researchers believed. The study, instead, suggested that the underlying cause of glucose intolerance was the impaired use of chromium.…”

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confidence: 95%

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Serum Chromium and Gestational Diabetes

Woods¹,

Ghodsi²,

Engel³

et al. 2008

The Journal of the American Board of Family Medicine

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Objective: To prospectively assess if chromium levels are different in gestational diabetics than in nondiabetic pregnant women. Therapeutic options could exist if levels are different.Methods: We conducted a 2-year prospective, gestational cohort study. The cohort included newly diagnosed pregnant patients. Two blood samples were taken, the first at consent, the second at the time of diabetes screening.Results: Five hundred eighty patients entered the cohort. One hundred fifty-five were lost to follow up and 425 patients completed the study (396 nondiabetics and 29 diabetics). The patients with gestational diabetes were significantly older, with a family history of gestational diabetes, and were significantly more likely to have been a gestational diabetic in a previous pregnancy (P < 05). There was no significant difference between the 2 groups for chromium levels both at enrollment (0.15 ؎ 0.06 ng/mL vs 0.14 ؎ 0.03 ng/mL; P ‫؍‬ .28) and during the second trimester (0.14 ؎ 0.06 ng/mL vs 0.14 ؎ 0.04 ng/mL; P ‫؍‬ .82).Conclusion: Serum chromium levels do not exhibit any significant variation between gestational diabetic women and nondiabetic women when assessed prospectively.

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Hair chromium content of women with gestational diabetes compared with nondiabetic pregnant women

Cited by 48 publications

References 24 publications

Serum chromium does not predict glucose tolerance in late pregnancy

Serum chromium does not predict glucose tolerance in late pregnancy

Monitoring exposure to heavy metals among children in Lake Victoria, Kenya: Environmental and fish matrix

Serum Chromium and Gestational Diabetes

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