Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage

Cotanche, Douglas A.; Lee, Kenneth H.; Stone, Jennifer S.; Picard, Daniel A.

doi:10.1007/bf00193125

Cited by 148 publications

(72 citation statements)

References 84 publications

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“…In chicks, a descending proximo-distal gradient of GTTR uptake, particularly in hair cells along the neural edge, is similar to the pattern of avian hair cell death following aminoglycoside treatment (Bhave et al, 1995;Cotanche et al, 1994;Hashino et al, 1995b). Recent studies show that noise-trauma can induce avian hair cell death processes within 3−6 h of insult (Mangiardi et al, 2004).…”

Section: Chicksmentioning

confidence: 73%

Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo

et al. 2006

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Aminoglycoside uptake in the inner ear remains poorly understood. We subcutaneously injected a fluorescently-conjugated aminoglycoside, gentamicin-Texas Red (GTTR), to investigate the in vivo uptake of GTTR in the inner ear of several vertebrates, and in various murine sensory cells using confocal microscopy.In bullfrogs, GTTR uptake was prominent in mature hair cells, but not in immature hair cells. Avian hair cells accrued GTTR more rapidly at the base of the basilar papilla. GTTR was associated with the hair bundle; and, in guinea pigs and mice, somatic GTTR fluorescence was initially diffuse before punctate (endosomal) fluorescence could be observed. A baso-apical gradient of intracellular GTTR uptake in guinea pig cochleae could only be detected at early time points (<3 h). In 21−28 day mice, cochlear GTTR uptake was greatly reduced compared to guinea pigs, 6-day-old mice, or mice treated with ethacrynic acid. In mice, GTTR was also rapidly taken up, and retained, in the kidney, dorsal root and trigeminal ganglia. In linguinal and vibrissal tissues rapid GTTR uptake cleared over a period of several days.The preferential uptake of GTTR by mature saccular, and proximal hair cells resembles the pattern of aminoglycoside-induced hair cell death in bullfrogs and chicks. Differences in the degree of GTTR uptake in hair cells of different species suggests variation in serum levels, clearance rates from serum, and/or the developmental and functional integrity of the blood-labyrinth barrier. GTTR uptake by hair cells in vivo suggests that GTTR has potential to elucidate aminoglycoside transport mechanisms into the inner ear, and as a bio-tracer for in vivo pharmacokinetic studies.

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Section: Chicksmentioning

confidence: 73%

Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo

et al. 2006

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“…Previous studies have shown that treatment with a combination of ototoxic drugs and intense sound exposure causes larger hair cell lesions than either drugs or sound presentation alone (Bone and Ryan, 1978;Collins, 1988;Brummett et al, 1990Brummett et al, , 1992Pye and Collins, 1991). Treatment with only low-frequency sound exposure does not result in hair cell damage localized to the apical end of the basilar papilla Rubel, 1982, 1985;Cotanche et al, 1994;Woolley, unpublished observations). Instead, lesions are spread out along the length of the papilla or occur in patches.…”

Section: Methodsmentioning

confidence: 92%

High-Frequency Auditory Feedback Is Not Required for Adult Song Maintenance in Bengalese Finches

Woolley

Rubel

1999

J. Neurosci.

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Male Bengalese finches do not normally change their vocal patterns in adulthood; song is stereotyped and stable over time. Adult song maintenance requires auditory feedback. If adults are deafened, song will degrade within 1 week. We tested whether feedback of all sound frequencies is required for song maintenance. The avian basilar papilla is tonotopically organized; hair cells in the basal region encode high frequencies, and low frequencies are encoded in progressively apical regions. We restricted the spectral range of feedback available to a bird by killing either auditory hair cells encoding higher frequencies or those encoding both high and low frequencies and documented resultant changes in song. Birds were treated with either Amikacin alone to kill high-frequency hair cells or Amikacin and sound exposure to target hair cells across the entire papilla. During treatment, song was recorded from all birds weekly. After treatment and song recording, evokedpotential audiograms were evaluated on each bird, and papillas were evaluated by scanning electron microscopy. Results showed that hair cell damage over 46-63% of the basal papilla and the corresponding high-frequency hearing loss had no effect on song structure. In birds with hair cell damage extending further into the apical region of the papilla and corresponding low-frequency and high-frequency hearing loss, song degradation occurred within 1 week of beginning treatment and was comparable with degradation after surgical deafening. We conclude that either low-frequency spectral cues or temporal cues via feedback of the song amplitude envelope are sufficient for song maintenance in adult Bengalese finches.

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“…The avian inner ear provides a useful model for the study of hair-cell regeneration and recovery in the vertebrate ear, but the ultimate value of this regenerative capacity depends on whether it results in functional recovery of auditory and vocal behavior (1)(2)(3). In response to either acoustic trauma or insult from ototoxic drugs, both young and adult birds show a temporary period of hair-cell loss and regeneration, usually culminating in considerable anatomical, physiological, and behavioral recovery within several weeks (4)(5)(6)(7)(8)(9)(10)(11)(12).…”

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confidence: 99%

Recovery of hearing and vocal behavior after hair-cell regeneration

Dooling

Ryals²,

Manabe

1997

Proc. Natl. Acad. Sci. U.S.A.

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Postmitotic hair-cell regeneration in the inner ear of birds provides an opportunity to study the effect of renewed auditory input on auditory perception, vocal production, and vocal learning in a vertebrate. We used behavioral conditioning to test both perception and vocal production in a small Australian parrot, the budgerigar. Results show that both auditory perception and vocal production are disrupted when hair cells are damaged or lost but that these behaviors return to near normal over time. Precision in vocal production completely recovers well before recovery of full auditory function. These results may have particular relevance for understanding the relation between hearing loss and human speech production especially where there is consideration of an auditory prosthetic device. The present results show, at least for a bird, that even limited recovery of auditory input soon after deafening can support full recovery of vocal precision.The avian inner ear provides a useful model for the study of hair-cell regeneration and recovery in the vertebrate ear, but the ultimate value of this regenerative capacity depends on whether it results in functional recovery of auditory and vocal behavior (1-3). In response to either acoustic trauma or insult from ototoxic drugs, both young and adult birds show a temporary period of hair-cell loss and regeneration, usually culminating in considerable anatomical, physiological, and behavioral recovery within several weeks (4-12). Behavioral recovery, as typically defined, refers only to a return of absolute auditory sensitivity to near pretrauma levels (13-16). Much less is known about the recovery of more complex auditory behavior, and nothing is known about the effect of hearing loss and recovery on the production or recognition of learned vocalizations. Though evolutionarily distant from humans, birds provide the only animal model for studying hearing restoration by renewed sensory-cell input and for examining the effect of such recovery on learned vocalizations. The question is whether a ''new'' auditory periphery results in sufficient functional recovery that a bird can again perceive, learn, and produce complex acoustic communication signals. The nature of this recovery bears on fundamental issues in auditory plasticity and sensorimotor interfaces. Moreover, the ability to track the time course of such recovery in a vertebrate auditory system may have particular significance for the effective use of auditory prosthetic devices, such as cochlear implants, for the severely hearing impaired (17).Budgerigars (domesticated parakeets), learn new vocalizations throughout life, especially in response to changes in their social milieu (18)(19)(20). Further, our work, as well as the work of others, has shown that these birds experience hair-cell loss and threshold shift after administration of the ototoxic drug kanamycin followed, within several days or weeks, by hair-cell regeneration and a gradual recovery to within 20 dB of normal auditory sensitivity (21,22). In th...

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Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage

Cited by 148 publications

References 84 publications

Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo

Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo

High-Frequency Auditory Feedback Is Not Required for Adult Song Maintenance in Bengalese Finches

Recovery of hearing and vocal behavior after hair-cell regeneration

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