Hair bundles: keeping it together

LeMasurier, Meredith; Gillespie, Peter G.

doi:10.1038/nn0107-11

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Indeed, several essential features of hair cells are derived and made possible by exclu- sive expression of specific proteins in subcellular compartments. Whereas most of the mechanosensory apparatus such as transduction channels and adaptation motor are expressed at or in close proximity to apical stereociliary bundle membranes (45,46), prestin, the motor protein of outer hair cells (27), voltage-gated ion channels, and synaptic protein machinery are compartmentalized at the basolateral membrane. Although until now studies on the role of membrane lipid compartmentalization in hair cells remained limited, in heterologous expression systems, prestin floats in low-density membrane fractions and associates with markers of lipid microdomains (24).…”

Section: Discussionmentioning

confidence: 99%

Plasticity in Membrane Cholesterol Contributes toward Electrical Maturation of Hearing

Levic

Yamoah

2011

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Plasticity in Membrane Cholesterol Contributes toward Electrical Maturation of Hearing

Levic

Yamoah

2011

Journal of Biological Chemistry

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“…The connection of MET channel with tip links is depicted in this schematic of an apical hair cell section. (LeMasurier and Gillespie, 2007) The hair bundles of IHCs have no physical contact to the lower surface of the tectorial membrane, whereas the tips of the hair bundles of OHCs touch the tectorial membrane. Vertical vibration of the basilar membrane due to a sound stimulus lifts and lowers the Organ of Corti which causes a shearing force between the hair bundle of OHCs and the tectorial membrane leading to a displacement of the tips of the stereocilia bundle.…”

Section: Figure I5: Apical Section Of a Hair Cellmentioning

confidence: 99%

Biochemistry and physiological role of otoferlin

Kirsten¹

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Spontaneous activity of striatal projection neurons supports maturation of striatal inputs to substantia nigra dopaminergic neurons

Kokinovic,

Seja,

Donati

et al. 2024

Preprint

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Spontaneous activity of neurons during early ontogenesis is instrumental for stabilization and refinement of developing neuronal connections. The role of spontaneous activity in synaptic development has been described in detail for cortical-like structures. Yet, very little is known about activity-dependent development of long-range inhibitory projections, such as projections from striatum. Here, we show that striatal projection neurons (SPNs) in dorsal striatum are spontaneously active in P4-P14 mice. Spontaneous activity was detected in both direct-pathway SPNs (dSPNs) and indirect-pathway SPNs (iSPNs). Most of the spontaneously active cells were in striosomes – a chemical compartment in striatum defined by expression of µ-opioid receptor. Higher excitability of both striosomal dSPNs and iSPNs was related to their intrinsic excitability properties (higher action potential half-width and IV slope). Tonic activation of muscarinic M1 receptor maintains the spontaneous activity of striosomal SPNs, the effect being stronger in iSPNs and weaker in dSPNs. To investigate if the neonatal spontaneous activity is needed for the stabilization of SPN long-range projections, we chemogenetically inhibited striosomal SPNs in neonatal animals and studied the efficiency of striatonigral projections in adult animals. Inhibition of striosomal SPNs by chronic CNO administration to P6-14 pups caused a reduction in the functional GABAergic innervation and in the density of gephyrin puncta in dopaminergic neurons of substantia nigra pars compacta of the adult (P52-79) animals. Chronic administration of CNO later in development (P21-29), on the contrary, resulted in higher mIPSC frequency in dopaminergic cells of the adult animals. Thus, the activity-dependent stabilization of striosomal projections has different developmental phases, and the long-term outcome of perturbations in these processes depends on the developmental period when they occur. Taken together, our results demonstrate that spontaneous activity of SPNs is essential for the maturation and stabilization of striatal efferents.

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Hair bundles: keeping it together

Cited by 3 publications

References 6 publications

Plasticity in Membrane Cholesterol Contributes toward Electrical Maturation of Hearing

Plasticity in Membrane Cholesterol Contributes toward Electrical Maturation of Hearing

Biochemistry and physiological role of otoferlin

Spontaneous activity of striatal projection neurons supports maturation of striatal inputs to substantia nigra dopaminergic neurons

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