Hair as a Biopsy Material

Klevay, Leslie M.

doi:10.1001/archinte.1978.03630320065021

Cited by 22 publications

(4 citation statements)

References 14 publications

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“…However, this rise may simply reflect the lower average initial values in this particular statistical set. Hair zinc concentration is considered by some a useful measure of zinc status [32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans

et al. 1987

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The comparative absorption of zinc after oral administration of three different complexed forms was studied in 15 healthy human volunteers in a double-blind four-period crossover trial. The individuals were randomly divided into four groups. Each group rotated for four week periods through a random sequence of oral supplementation including: zinc picolinate, zinc citrate, and zinc gluconate (equivalent to 50 mg elemental zinc per day) and placebo. Zinc was measured in hair, urine, erythrocyte and serum before and after each period. At the end of four weeks hair, urine and erythrocyte zinc levels rose significantly (p less than 0.005, p less than 0.001, and p less than 0.001) during zinc picolinate administration. There was no significant change in any of these parameters from zinc gluconate, zinc citrate or placebo administration. There was a small, insignificant rise in serum zinc during zinc picolinate, zinc citrate and placebo supplementation. The results of this study suggest that zinc absorption in humans can be improved by complexing zinc with picolinic acid.

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Section: Discussionmentioning

confidence: 99%

Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans

et al. 1987

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“…However, acid digestion of whole blood is required before analysis and data are limited [41]. The selenium content of hair [43, 44] and toenails [45, 46] can also be used to assess longer term selenium status. However, although these samples can be easily stored at room temperature for long periods of time and they show quite a good correlation with other selenium biomarkers, their analysis by nuclear absorption is expensive and lack of external contamination must be assured.…”

Section: Analysis Of Nutrient Statusmentioning

confidence: 99%

Nutrition and allergic disease

et al. 2006

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Summary The prevalence of asthma and allergic diseases has increased dramatically over the past few decades with the highest incidence occurring in children. Most asthma and related atopic disorders have their origins in early life. Thus, it is imperative to understand the early life origins of the disease in order to identify targets for prevention and early intervention. Although atopic diseases have genetic determinants, the increased incidence of these diseases has occurred far too rapidly for genetic changes to explain the increase. This, most likely, results from changes in environmental influences acting on a pre‐existent genetic susceptibility. One of the environmental changes over the last 20–40 years that could have contributed to the recent increase in atopic diseases is diet. Food allergy is often one of the earliest manifestations of atopy, and sensitization to food is a risk factor for the subsequent appearance of respiratory allergy and asthma. However, studies investigating the effects of dietary restrictions on the prevention of allergy have been disappointing. On the other hand, current data suggests that exclusive breastfeeding should be encouraged for at least 4–6 months in infants at both high and low risk of atopy. Increased risk of asthma has also been observed in low birth weight infants, suggesting that under‐nutrition can detrimentally alter foetal development. Epidemiological and immunological studies also suggest that dietary modification or supplementation in the foetal and early life could reduce the development of atopic diseases. The current dietary hypotheses relate to antioxidants, lipids, electrolytes and probiotics. The aims of this report are: (i) to assess the best methods to analyse nutrient intake and nutrient status; (ii) to review the existing epidemiological evidence for an association between dietary intake (nutrients and food) and allergic diseases; and (iii) to define the windows of opportunity for nutritional supplementation to be used as a preventative strategy for asthma and allergy.

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“…Abnormal concentrations of As, Hg, Pb, and Cd in hair have been observed in exposed populations [Hammer et al, 1971;Klevay, 1973;Arunachalam et al, 1978;Chattopadhyay et al, 1974;Al-Sharistani et al, 19761. Also, it has been reported that the elemental concentration of heavy metals in human hair may be correlated to the exposure conditions as judged by the level of contamination found in food, air, water, or soil [Klevay, 1973;Chattopadhyay et a]., Al-Sharistani et al, 19761. There is, however, only limited data on the relationship between elemental composition of hair and the concentration of these elements in different body tissues [Kowal et al, 19791.…”

Section: Introductionmentioning

confidence: 99%

Hair cadmium content: Is it a biological indicator of the body burden of cadmium for the occupationally exposed worker?

Ellis

Yasumura

Cohn

1981

American J Industrial Med

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The primary objective of this study was to evaluate the cadmium (Cd) levels measured in scalp hair as a potential predictive index of the body burden of Cd. In vivo measurements of kidney and liver Cd along with hair, blood, and urine Cd levels were obtained in 29 industrially-exposed workers and ten control subjects. The relationship of hair Cd levels to the Cd values for the kidney, liver, blood, and urine were tested using nonparametric analyses. In the control group no statistically significant correlations were found. In the Cd-exposed workers with more than one year of employment there were weak correlations (p approximately equal to 0.05); however, the relationships were not sufficiently quantitative for predicting the status of an individual worker. Furthermore, when workers with less than one year of exposure were included in the analysis, no significant correlations were obtained. Although this latter group of workers had low body burdens of Cd, exceptionally high Cd concentrations were found in their hair--an observation that was unexpected. It was concluded that hair Cd levels are not a good index of body burden of Cd in the industrially-exposed individual.

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Hair as a Biopsy Material

Cited by 22 publications

References 14 publications

Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans

Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans

Nutrition and allergic disease

Hair cadmium content: Is it a biological indicator of the body burden of cadmium for the occupationally exposed worker?

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