Hair analysis for cocaine: Factors in laboratory contamination studies and their relevance to proficiency sample preparation and hair testing practices

Hill, Virginia; Cairns, Thomas; Schäffer, Michael

doi:10.1016/j.forsciint.2007.08.011

Cited by 39 publications

(37 citation statements)

References 10 publications

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“…In other words, "hair porosity" should be considered in evaluating external contamination. Hill et al 58) applied a method for determining hair porosity to hair specimens, and the porosity charac-teristics of hair are discussed in relation to experimental and actual contamination of hair.…”

Section: Hairmentioning

confidence: 99%

Analysis of Drugs of Abuse in Biological Specimens

Saito

Kikuchi

et al. 2011

JOURNAL OF HEALTH SCIENCE

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Recent reports of the analysis of drugs of abuse in biological specimens are reviewed herein. Different perspectives from reviews so far published and the need for and the background of drug analysis in biological specimens, and difficulty of drug testing in biological specimens are introduced. Comprehensive biological specimens for the analysis of drugs of abuse in forensic science, including oral fluid (saliva), hair, umbilical cord, placenta, meconium, cadaver tissue (brain, adipose), sweat, breath, and nail clippings, in addition to the commonly used blood and urine specimens in clinical chemistry, are described along with their outlines, advantages/disadvantages, and actual examples. Today, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the method of choice for the analysis of drugs of abuse. A simultaneous screening method for multiple types of drugs has also become popular recently. However, because qualitative determination remains important in forensic science, gas chromatographymass spectrometry (GC-MS) is still in use even if it requires complicated specimen preparation and derivatization procedures. This is because GC-MS is reliable and has been employed ever since for the appraisal of trials.

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Section: Hairmentioning

confidence: 99%

Analysis of Drugs of Abuse in Biological Specimens

Saito

Kikuchi

et al. 2011

JOURNAL OF HEALTH SCIENCE

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“…This perspiration may also deposit drugs on the external surface of the hair and, because it cannot be assumed that all drug users shampoo their hair adequately to remove this, the laboratory must be responsible for removing or minimizing such drug deposits in their analytical results if they are to be accurate in terms of quantities of parent drug or metabolites related to ingestion. Studies on the nature and removal of externally deposited drugs on hair have been ongoing since the early years of hair analysis research [4]. Morphine (5,6-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol) is a therapeutic drug that is commonly used for the control of pain and is also abused as an illicit drug.…”

Section: Introductionmentioning

confidence: 99%

Silane modified magnetic nanoparticles as a novel adsorbent for determination of morphine at trace levels in human hair samples by high-performance liquid chromatography with diode array detection

Boojaria

Masrournia

Ghorbani

et al. 2015

Forensic Sci Med Pathol

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In this paper we report a novel, sensitive, and rapid method of magnetic solid phase extraction based on surface modified magnetic nanoparticles as a novel nano sorbent for HPLC determination of morphine with diode array detection in human hair samples. Factors affecting the extraction efficiency of the proposed method, including the sample pH, quantity of magnetic nanoparticles, sample volume, desorption solvent type and its volume, and extraction time were investigated and optimized. Under the optimized experimental conditions, a good linearity was observed in the range of 1-800 µgL(-1) for the morphine, with a correlation coefficient (R (2)) of 0.990. The pre-concentration factor of 208.69 was achieved in this method. The detection limit of the method was 0.1 μgL(-1) based on S/N = 3 and good reproducibility with a relative standard deviations lower than (n = 5) 2.59 %. The proposed method has been successfully applied to the analysis of trace amounts of morphine in human hair samples with satisfactory results. This method can be applied in medical toxicology research and forensic medical centers.

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“…5 Several analytical methods for COC and BZE detection have been reported in different biological matrices such as whole blood 6,7 , brain 6 , plasma 8 , nails 9 , saliva 10,11 , urine 12 , hair. 13,14 They include GC/MS, HPLC-APCI-MS/MS, GC/ NPD, and HPLC-MS/MS techniques.…”

Section: Introductionmentioning

confidence: 99%

Validation of a Method to Detect Cocaine and Benzoylecgonine in Human Whole Blood by Gas Chromatography-Mass Spectrometry and Application in Body Packers and Stuffers Cases in the North of Chile

Bravo

Contzen²,

Mollo

et al. 2012

J. Chil. Chem. Soc.

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The present paper describes a method for the simultaneous determination of cocaine and benzoylecgonine in human whole blood. The drugs were extracted with phosphate buffer at pH 6, followed by solid-phase extraction and quantification by GC/MS with electron impact ionization using helium as carrier gas. Quantification was performed using cocaine-d3 as internal standard in selected ion monitoring mode. The method is very simple, rapid and sensitive. The specificity, linearity, intra-and inter-assay precision and accuracy, and extraction recovery were fully evaluated. The limits of detection were 3.6 ng/mL for cocaine and 6.8 ng/mL for benzoylecgonine. The method was applied to blood samples removed at autopsy from body packers and stuffers cases in the I -IV and XV regions of Chile during 2008-2010.

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Hair analysis for cocaine: Factors in laboratory contamination studies and their relevance to proficiency sample preparation and hair testing practices

Cited by 39 publications

References 10 publications

Analysis of Drugs of Abuse in Biological Specimens

Analysis of Drugs of Abuse in Biological Specimens

Silane modified magnetic nanoparticles as a novel adsorbent for determination of morphine at trace levels in human hair samples by high-performance liquid chromatography with diode array detection

Validation of a Method to Detect Cocaine and Benzoylecgonine in Human Whole Blood by Gas Chromatography-Mass Spectrometry and Application in Body Packers and Stuffers Cases in the North of Chile

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