Hailey-Hailey disease treated successfully with naltrexone and magnesium

Alajmi, Ali; Jfri, Abdulhadi; Lovett, Audrey

doi:10.1016/j.jdcr.2019.06.022

Cited by 11 publications

(10 citation statements)

References 9 publications

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“…In February 2020, the patient decided to start oral magnesium chloride solution at 300 mg/day nightly in addition to her naltrexone after reading a case report on HHD treated with this combination. 6 Within 6 months of this combination, further decrease in episode frequency was observed, with only one exacerbation during summertime which was less severe than initial episodes. A timeline of management is presented in Figure 3 .…”

Section: Case Reportmentioning

confidence: 87%

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Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report

Lim

Bélisle

Davar

2020

SAGE Open Medical Case Reports

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Hailey–Hailey disease is a rare autosomal dominant acantholytic disorder due to mutation in the ATP2C1 gene and presents with flaccid blisters in intertriginous regions. Its chronic and relapsing course may negatively impact patients’ quality of life. Multiple medical and interventional treatments have been described with various efficacy. Low-dose naltrexone and oral magnesium chloride represent emerging treatments. Sustained improvement in Hailey–Hailey disease has been reported with the former in case series, while others have shown variable results. Oral magnesium chloride has been reported in four patients with possible results after 2–4 weeks. Two recent cases suggest that the combination of both treatments may have a synergistic effect. Herein, we present a 63-year-old woman with long-standing and recurrent bilateral inguinal Hailey–Hailey disease who significantly improved with low-dose naltrexone and oral magnesium chloride, representing the third case described with this combination.

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Section: Case Reportmentioning

confidence: 87%

“…More recently, significant improvement was reported in a man with recalcitrant HHD within 2 weeks of naltrexone at 4.5 mg combined with magnesium chloride at 286 mg daily, started simultaneously. 6 …”

Section: Discussionmentioning

confidence: 99%

Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report

Lim

Bélisle

Davar

2020

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

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“…HHD is a rare inherited disease that is caused by a mutation of ATP2C1 , which encodes for a magnesium-dependent calcium pump [ 6 , 7 ]. It was first described in 1939 by brothers Hailey and Hailey as an autosomal dominant disorder which manifests as recurrent episodes of pruritic vesicles and erosions [ 4 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…HHD is not a life-threatening disease, but it may decrease patients' quality of life significantly [ 6 ]. We report the case of an 84-year-old male that presented with recurrent nonresolving ulcerations in the mouth.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Ulcerations in an 84-Year-Old Male Diagnosed with Hailey-Hailey Disease

Qooz¹,

Almuharraqi²,

Salam³

et al. 2020

Case Rep Dermatol

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Hailey-Hailey disease (HHD), or familial benign chronic pemphigus, is a rare inherited acantholytic dermatosis. It is an autosomal dominant disease affecting the intertriginous areas. HHD has been characterized by flaccid blisters, erosions, and macerations that are limited to flexural (friction-prone) areas. The painful blisters and erosions significantly decrease patients’ quality of life. There are multiple types of therapy related to this disorder. Many of the studies have suggested benefits from steroid therapy in addition to oral antibiotics.

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“…More recently, there has been a description of the use of botulinum toxin, naltrexone, and magnesium chloride with potentially promising results. 3,4 The magnesium ion (Mg 2+ ) represents the second most abundant intracellular cation and is essential in biochemical processes. 5 It is the cofactor of more than 300 enzymatic reactions involving kinases, cell metabolism, energy production, protein synthesis, modulation of transmembrane transport of sodium and potassium, as well as cytoskeletal function and maintenance of cell integrity.…”

mentioning

confidence: 99%

Successful treatment of refractory Hailey‐Hailey disease with oral magnesium chloride

Garcia¹,

Baréa²,

Bauer³

et al. 2020

Dermatologic Therapy

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Hailey-Hailey disease (HHD), or familial benign chronic pemphigus, is a rare autosomal dominant genodermatosis with complete penetrance that affects the ATP2C1 gene, located in the long arm of chromosome 3 and responsible for encoding the calcium ATPase enzyme of the Golgi complex. Defective calcium channels in keratinocytes impair the formation of desmosome adhesion proteins and lead to acantholysis. 1-3 The estimated incidence is 1/50000 individuals, 3 and the condition usually appears between the second and fourth decades of life. 2,4 Clinically, it presents with eroded, macerated, vegetating, malodorous plaques in intertriginous areas. 1,3,4 Secondary infections are frequent and relevant in the exacerbation of the condition. 3,4 We describe the case of a healthy 42-year-old woman who had erythematous, macerated, crusted, painful plaques with a foul odor bilaterally in the inframammary regions for 4 years (Figure 1A). She eventually had similar lesions in the groins, but to a lesser extent.

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Hailey-Hailey disease treated successfully with naltrexone and magnesium

Cited by 11 publications

References 9 publications

Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report

Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report

Recurrent Ulcerations in an 84-Year-Old Male Diagnosed with Hailey-Hailey Disease

Successful treatment of refractory Hailey‐Hailey disease with oral magnesium chloride

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