Hailey-Hailey disease successfully treated with vitamin D oral supplementation

Abstract

Hailey-Hailey disease (HHD) also known as familial benign chronic pemphigus is a rare autosomal dominant genodermatosis. HHD treatment is often not satisfactory and hence, various modalities of treatment have been tried. We describe the case of a 37-year-old woman with a 2 years history of macerated erythematous plaques along with erosions, fissures, and crusts located on axillae and submammary areas, successfully treated with only oral supplementation of vitamin D (800 I.U./die) for 3 months. We reported this case to suggest that oral vitamin D may be enumerated in the various treatments proposed for HHD so far due to its rapid efficacy on skin lesions and symptoms. K E Y W O R D S 1α,24-dihydroxyvitamin D3, familial benign chronic pemphigus, Hailey-Hailey disease, treatment, vitamin D

Darier and Hailey‐Hailey disease: update 2021

“…Other individual case reports have been published, using high doses of vitamin D3 (8000 IU per day) [119] as well as the anticholinergics glycopyrrolate [120] and oxybutynin [121] for successful reduction of sweating.…”

Atypical discoid eczema-like presentation of Hailey-Hailey disease

“…[5] Few case reports have demonstrated favorable response with narrowband UV-B therapy [6] and Vitamin D supplementation. [7] Our patient had an atypical presentation with discoid eczema-like lesions over the trunk along with involvement of non-intertriginous areas. However, a clinicopathological correlation with a positive family history clinched the diagnosis.…”

Vitamin D in autoimmune bullous disease

“…This requires further research and clinical trials involving the pemphigus and pemphigoid patients. In fact, several case reports have described that the Hailey-Hailey disease, also known as a familial benign chronic pemphigus, can be successfully controlled with vitamin D analogues applied either orally or topically (Bianchi et al, 2004;Rajpara & King, 2005;Megna et al, 2019). Finally, because there are many case reports describing the coexistence of AIBD and psoriasis (Ohata et al, 2015), the role of topically applied vitamin D analogues in the treatment of these disorders needs to be properly evaluated.…”