Hafnium Oxide Nanoparticles as a Promising Emergent Treatment for Head And Neck Cancer

Tourneau, C. Le; Calugaru, Valentin; Thariat, Juliette; Florescu, C.; Mirabel, X.; Jégoux, Franck; Jouffroy, Thomas; Rodriguez, J; Hoffmann, Caroline; Dodger, B.; Moreno, Víctor; Dimitriu, Mikaela; Lévy, Laurent; Calvo, Emiliano

doi:10.1016/j.ijrobp.2017.12.180

Cited by 11 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, HfO2 is a metal oxide with a high melting point (~2700 °C), high dielectric constant, and a wide band gap of 5 eV. Because HfO2 is composed of Hf, a high Z element, it has been used for electronics and target therapy applications [153,156]. Herein, the radiosensitization of the metal oxides was evidenced by monitoring the decomposition of MB in the presence of the nanomaterial.…”

Section: Discussionmentioning

confidence: 99%

Au@TiO2 nanocomposites synthesized by X-ray radiolysis as potential radiosensitizers

Higgins

Clifford

Rojas

2018

Applied Surface Science

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Au@TiO2 nanocomposites synthesized by X-ray radiolysis as potential radiosensitizers

Higgins

Clifford

Rojas

2018

Applied Surface Science

View full text Add to dashboard Cite

“…Similarly, the long history of RT in practical radiation modes, benefits, and side effects elimination can also provide significant references for X-PDT as discussed above. For example, two RT sensitizers based on nanomaterials have been promoted to clinical trials, including the commercial product of NBTXR3 (Hensify) that was developed by Nanobiotix based on 50 nm-sized hafnium oxide nanoparticles and has recently been approved by European Medicines Agency (EMA) in trending adult soft tissue sarcoma, ,− and 15 other clinical trials underway. Meanwhile, the nanodrug of AGuIX developed by NH TherAguix based on a Gd-based nanoparticle has also entered a human phase 2 clinical trial on brain metastases, , as well as several phase 2 trials in nonsmall cell lung cancer, etc .…”

Section: Clinical Translationmentioning

confidence: 99%

Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses

2022

ACS Nano

View full text Add to dashboard Cite

The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires innovative solutions for its congenitally deficient shadow penetration of the visible-light excitation. X-ray-induced photodynamic therapy (X-PDT) has been proven to be a successful technique in reforming the conventional PDT for deep-seated tumors by creatively utilizing penetrating X-rays as external excitation sources and has witnessed rapid developments over the past several years. Beyond the proof-of-concept demonstration, recent advances in X-PDT have exhibited a trend of minimizing X-ray radiation doses to quite low values. As such, scintillating materials used to bridge X-rays and photosensitizers play a significant role, as do diverse well-designed irradiation modes and smart strategies for improving the tumor microenvironment. Here in this review, we provide a comprehensive summary of recent achievements in X-PDT and highlight trending efforts using low doses of X-ray radiation. We first describe the concept of X-PDT and its relationships with radiodynamic therapy and radiotherapy and then dissect the mechanism of X-ray absorption and conversion by scintillating materials, reactive oxygen species evaluation for X-PDT, and radiation side effects and clinical concerns on X-ray radiation. Finally, we discuss a detailed overview of recent progress regarding low-dose X-PDT and present perspectives on possible clinical translation. It is expected that the pursuit of low-dose X-PDT will facilitate significant breakthroughs, both fundamentally and clinically, for effective deep-seated cancer treatment in the near future.

show abstract

“…In enhancing radiosensitization effect to cancer cell-making, 50nm metallic nanoparticles of gold, silver and hafnium oxide nanoparticles perform better than other sizes. [10][11][12][13] Bimetallic colloids intrigue researchers due to their interesting structure and their unique catalytic, electronic and optical properties. 14 The bimetallic NPs based on structure are categorized as: (i) core-shell alloy, (ii) cluster in the cluster, and (iii) random alloy and alloy structures.…”

Section: Introductionmentioning

confidence: 99%

One Pot Synthesis of PEGylated Bimetallic Gold–Silver Nanoparticles for Imaging and Radiosensitization of Oral Cancers

Ahmed¹,

Baijal

Somashekar³

et al. 2021

IJN

View full text Add to dashboard Cite

Background:Radiotherapy is an important treatment modality for many types of head and neck squamous cell carcinomas. Nanomaterials comprised of high atomic number (Z) elements are novel radiosensitizers enhance radiation injury by production of free radicals and subsequent DNA damage. Gold nanoparticles are upcoming as promising radiosensitizers due to their high (Z) biocompatibility, and ease for surface engineering. Bimetallic nanoparticles have shown enhanced anticancer activity compared to monometallic nanoparticles. Materials and Methods: PEG-coated Au-Ag alloy nanoparticles (BNPs) were synthesized using facile one pot synthesis techniques. Size of ~50±5nm measured by dynamic light scattering. Morphology, structural composition and elemental mapping were analyzed by electron microscopy and SAXS (small-angle X-ray scattering). The radiosensitization effects on KB oral cancer cells were evaluated by irradiation with 6MV X-rays on linear accelerator. Nuclear damage was imaged using confocal microscopy staining cells with Hoechst stain. Computed tomography (CT) contrast enhancement of BNPs was compared to that of the clinically used agent, Omnipaque. Results: BNPs were synthesized using PEG 600 as reducing and stabilizing agent. The surface charge of well dispersed colloidal BNPs solution was −5mV. Electron microscopy reveals spherical morphology. HAADF-STEM and elemental mapping studies showed that the constituent metals were Au and Ag intermixed nanoalloy. Hydrodynamic diameter was ~50±5nm due to PEG layer and water molecules absorption. SAXS measurement confirmed BNPs size around 35nm. Raman shift of around 20 cm −1 was observed when BNPs were coated with PEG. 1 H NMR showed extended involvement of − OH in synthesis. BNPs efficiently enter cytoplasm of KB cells and demonstrated potent in vitro radiosensitization with enhancement ratio ~1.5-1.7. Imaging Hoechst-stained nuclei demonstrated apoptosis in a dose-dependent manner. BNPs exhibit better CT contrast enhancement ability compared to Omnipaque. Conclusion: This bimetallic intermix nanoparticles could serve a dual function as radiosensitizer and CT contrast agent against oral cancers, and by extension possibly other cancers as well.

show abstract

Hafnium Oxide Nanoparticles as a Promising Emergent Treatment for Head And Neck Cancer

Cited by 11 publications

References 0 publications

Au@TiO2 nanocomposites synthesized by X-ray radiolysis as potential radiosensitizers

Au@TiO2 nanocomposites synthesized by X-ray radiolysis as potential radiosensitizers

Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses

One Pot Synthesis of PEGylated Bimetallic Gold–Silver Nanoparticles for Imaging and Radiosensitization of Oral Cancers

Contact Info

Product

Resources

About