Hafnium Oxide-Based Nanoplatform for Combined Chemoradiotherapy

Abstract

Recently, the combined therapy has become one of the main approaches in cancer treatment. Combining different approaches may provide a significant outcome by triggering several death mechanisms or causing increased damage of tumor cells without hurting healthy ones. The supramolecular nanoplatform based on a high-Z metal reported here is a suitable system for the targeted delivery of chemotherapeutic compounds, imaging, and an enhanced radiotherapy outcome. HfO2 nanoparticles coated with oleic acid and a monomethoxypoly­(ethylene glycol)-poly­(ε-caprolactone) copolymer shell (nanoplatform) are able to accumulate inside cancer cells and release doxorubicin (DOX) under specific conditions. Neither uncoated nor coated nanoparticles show any cytotoxicity in vitro. DOX loaded onto a nanoplatform demonstrates a lower IC50 value than pure DOX. X-ray irradiation of cancer cells loaded with a nanoplatform shows a higher death rate than that for cells without nanoparticles. These results provide an important foundation for the development of complex nanoscale systems for combined cancer treatment.

Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium

“…Hafnium oxide is also one of the most commonly used antireflection coating materials for optical components due to a high refractive index coupled with a transparent spectral range between infrared and ultraviolet energies coupled and thermal stability . Some hafnium compounds such as hafnium oxide exhibit high chemical inertness and stability with established nanoscale synthesis capacity ,− minimizing toxicity in biological systems and enabling a multitude of medical applications. ,,,− Moreover, an advantageous distribution of mass attenuation coefficient values across the energy spectrum for clinical radiation-based therapy and imaging modalities alongside a well-placed k-edge absorption value lays the groundwork for multifunctional medical applications.…”

“…Hafnium-based nanomaterials can be designed to exhibit properties advantageous to a broad range of applications such as therapy radiosensitizers, ,,,,− X-ray-based imaging contrast agents, − ,− , sensor components, ,,− semiconductors, ,− ferroelectrics, − and optical device components. ,, As such, appropriate characterization methodology conducive to preparing materials with the relevant properties for each application is critical. Nanomaterial morphology encompasses particle size, shape, and composition .…”

“…Experimental results support both enhanced radiation effect and immune response. Sherstiuk et al studied an innovative supramolecular hafnium-based nanoplatform for joint chemo- and radiotherapy. The prepared material incorporated a copolymer shell for pH-sensitive doxorubicin release.…”

Osteogenic and Biomedical Prospects of Hafnium and Its Compounds: A Scoping Review

“…In the current research, the geographic distribution of the study centers is widespread. Of the included studies, five are from China, two studies from Russia and India each, one study from Japan and Poland each, and one from a multicenter study [ 23 , 24 ]. Due to the distribution of studies in a wide geographic range, the results can be extrapolated with minimal risk of bias.…”

“…The widespread use of this transition metal is researched in targeted RT, chemoradiotherapy, inflammatory bowel disease treatment, and bone tissue regeneration [ 34 , 35 ]. In previous studies on RT, hafnium has proven as a potential biomaterial [ 23 , 26 , 36 ].…”