Haemostatic variables associated with diabetes and its complications.

Fuller, J. H.; Keen, H.; Jarrett, R. J.; Omer, Tahir; Meade, T. W.; Chakrabarti, Ranjan; North, W. R. S.; Stirling, Yvonne

doi:10.1136/bmj.2.6196.964

Cited by 278 publications

(129 citation statements)

References 18 publications

(2 reference statements)

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“…Albuminuria and hyperfibrinogenaemia, another cardiovascular risk factor, are frequently associated [7,8] in diabetes. Such an association is important in that fibrinogen, an acutephase protein, is a powerful and independent cardiovascular risk factor [1][2][3]. However, the mechanism(s) of the association between hyperfibrinogenaemia and albuminuria, as well as the response of hepatic albumin synthesis to albuminuria in type 2 diabetes, are not known.…”

Section: Discussionmentioning

confidence: 99%

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Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

et al. 2006

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Aims/hypothesis: Hyperfibrinogenaemia and albuminuria are cardiovascular risk factors, often coexisting in diabetic and non-diabetic people. Albuminuria in turn is associated with a compensatory albumin overproduction in non-diabetic patients. It is not known whether the presence of albuminuria in patients with type 2 diabetes mellitus is associated with greater albumin and fibrinogen production rates than in normoalbuminuric patients. Subjects, materials, and methods: Using leucine isotope methods, we measured fractional and absolute synthesis rates (FSR, ASR) of albumin and fibrinogen in post-absorptive type 2 diabetic patients with either normal (n=11) or increased (n=10) urinary albumin excretion. Results: In albuminuric patients, albumin FSR (16.2± 1.5%/day) and ASR (20.5±1.9 g/day) were greater (p<0.02 and p<0.05, respectively) than in normoalbuminuric patients (FSR=11.5±1.1%/day; ASR=15.7±1.2 g/day). Fibrinogen FSR was similar between patients with normal and increased albumin excretion, but concentration, the circulating pool and ASR of fibrinogen were 40 to 50% greater (p<0.035) in patients with albuminuria. Albuminuria was positively correlated with albumin ASR, with fibrinogen concentration, the fibrinogen pool and ASR, whereas albumin synthesis was inversely correlated with calculated oncotic pressure. Conclusions/interpretation: Synthesis of albumin and fibrinogen is upregulated in type 2 diabetic patients with increased urinary albumin excretion. Albuminuria is associated with enhanced fibrinogen and albumin synthesis.

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Section: Discussionmentioning

confidence: 99%

“…Hyperfibrinogenaemia and albuminuria are established cardiovascular risk factors in diabetic and in non-diabetic populations [1][2][3]. Hyperfibrinogenaemia is common in type 2 diabetes, and is often associated with albuminuria [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

et al. 2006

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“…The excess cardiovascular morbidity and mortality among diabetics have not been fully explained by major risk factors such as hypertension, cigarette smoking and hypercholesterolemia. Increased attention is being paid to, disordered hemostatic mechanism in pathogenesis of both large vessel and small vessel disease in diabetes [3]. Impaired glucose tolerance exerts an influence by enhancing thrombogenic factors such as, fibrinogen in the diabetics [4].…”

Section: Introductionmentioning

confidence: 99%

“…The present study is undertaken to know the levels of fibrinogen in type 2 diabetes mellitus and its relation with glycemic control. Evidence of increased thrombotic tendency in diabetes would have etiological, preventive and therapeutic implications [3]. Cardiovascular complications account for nearly 50% of deaths in type 2 diabetes mellitus and 25% in type 1 patients.…”

Section: Introductionmentioning

confidence: 99%

A Study of Plasma Fibrinogen Level in Type-2 Diabetes Mellitus and its Relation to Glycemic Control

Bembde

2011

Indian J Hematol Blood Transfus

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The high prevalence of classic cardiac risk factors in patients with type 2 diabetes mellitus does not explain the increased cardiovascular related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. This study is undertaken to know the fibrinogen levels in type 2 diabetes mellitus and its relations to glycemic control. In the present study fibrinogen levels (Clauss method) were estimated in 100 type 2 diabetic subjects and 100 age and sex matched controls. Fibrinogen was correlated with various parameters like glycosylated hemoglobin (cation exchange resin method), age, sex, smoking, body mass index (kg/m 2 ), hypertension and ischemic heart disease. Higher plasma fibrinogen levels were found in type 2 diabetes mellitus patients (656 ± 130 mg/dl) as compared to controls (324 ± 139 mg/dl) which were statistically significant. Fibrinogen levels were associated with age (P \ 0.01), hypertension (P \ 0.01), body mass index (P \ 0.01), smoking (P \ 0.01), ischemic heart disease (P \ 0.01), and glycosylated hemoglobin (r = 0.49) in diabetics in a significant manner. But no correlation was found with sex (P \ 0.05) in diabetes. In controls, association was found between fibrinogen levels and smoking (P \ 0.01) and body mass index (P \ 0.01). Patients with type 2 diabetes mellitus had a high prevalence of hyperfibrinogenemia. Fibrinogen levels were independently associated with hemoglobin A1c values, which suggests that fibrinogen may be involved in the increased cardiovascular risk of patients with type 2 diabetes mellitus.

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“…Since increased factor VII levels have been reported in diabetes [5,6], the aim of this study is to evaluate the influence of hyperglycaemia on factor VII in both diabetic and normal subjects.…”

mentioning

confidence: 99%

Blood glucose may condition factor VII levels in diabetic and normal subjects

Ceriello¹,

Giugliano²,

Quatraro

et al. 1988

Diabetologia

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Summary. Increased factor VII levels have been reported in Type 1 (insulin-dependent) diabetic subjects. A direct correlation between fasting plasma glucose and factor VII level was found to exist in both diabetic and normal subjects. Inducedhyperglycaemia was able to increase factor VII levels in both diabetic patients and normal control subjects while, when euglycaemia was achieved in diabetic patients, factor VII values returned to normal range. This study shows that the level of factor VII may be directly conditioned by circulating blood glucose and, therefore, stresses the role of hyperglycaemia in conditioning coagulation abnormalities in diabetes mellitus.

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Haemostatic variables associated with diabetes and its complications.

Cited by 278 publications

References 18 publications

Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

A Study of Plasma Fibrinogen Level in Type-2 Diabetes Mellitus and its Relation to Glycemic Control

Blood glucose may condition factor VII levels in diabetic and normal subjects

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