Haemostatic profile of healthy premature small for gestational age neonates

Reference intervals for common coagulation tests of preterm infants (CME)

“…First, identifying a coagulation value as “abnormal” depends on having accurate reference intervals for comparison. Reference intervals for late preterm and term infants are available, but meager data are found for preterm infants . This is due, in part, to the large amount of blood needed for these tests relative to the patient's blood volume and the difficulty in obtaining blood samples that are reliably uncontaminated by heparin.…”

“…Thus, our impression that cord blood coagulation tests do not identify the neonates who will go on to have bleeding problems is tentative and subject to modification when thousands of preterm neonates have been similarly screened. The problems of small sample size is common to all previous reports of coagulation tests in preterm neonates . To lessen this problem, we attempted (Table ) to estimate the relevant reference intervals using data from the present plus previous studies and to propose tentative recommendations for management of preterm neonates.…”

“…The problems of small sample size is common to all previous reports of coagulation tests in preterm neonates . To lessen this problem, we attempted (Table ) to estimate the relevant reference intervals using data from the present plus previous studies and to propose tentative recommendations for management of preterm neonates. In doing this we endeavored to incorporate the published recommendations from the Poralla and Bartmann group from Germany, and the Venkatesh and Stanworth groups from Great Britan .…”

Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?

“…Although there was a significant difference in fibrinogen, factor VIIIc, similar to our findings, PT, INR, protein C, AT were not significantly differ between SGA and AGA group. [13] This study showed a direct relationship between protein S levels and birth weight independent of sex and GA. There are very limited studies regarding the coagulation factors in relation to the birth weight in neonatal population.…”

“…[13] There is no discussion about LGA neonates nor there is any role found for birth weight. Our study found that coagulation factors are different between different birth weight groups.…”