Hæmostatic Function and Cardiovascular Death: Early Results of a Prospective Study

Meade, T. W.; Chakrabarti, Ranjan; Haines, Andy; North, W. R. S.; Stirling, Yvonne; Thompson, S.G.; Brozović, Milica

doi:10.1016/s0140-6736(80)91498-1

Cited by 696 publications

(226 citation statements)

References 16 publications

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“…Of interest, moreover, is to consider that an increased risk of ischaemic heart disease, associated with high levels of factor VII [1], is frequently associated with impaired glucose tolerance [11]. This hypothesis supports the possibility to obtain normal factor VII levels, when euglycaemia is achieved in diabetic patients.…”

Section: Discussionmentioning

confidence: 79%

“…High levels of factor VII have been associated with an increased risk of both ischaemic heart disease [1] and atherosclerosis [21. It has long been known that diabetes mellitus is associated with an increased incidence of vascular disease, and several studies of the fluid phase of coagulation suggest that diabetes is associated with a hypercoagulable state [3,4].…”

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confidence: 99%

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Blood glucose may condition factor VII levels in diabetic and normal subjects

Ceriello¹,

Giugliano²,

Quatraro

et al. 1988

Diabetologia

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Summary. Increased factor VII levels have been reported in Type 1 (insulin-dependent) diabetic subjects. A direct correlation between fasting plasma glucose and factor VII level was found to exist in both diabetic and normal subjects. Inducedhyperglycaemia was able to increase factor VII levels in both diabetic patients and normal control subjects while, when euglycaemia was achieved in diabetic patients, factor VII values returned to normal range. This study shows that the level of factor VII may be directly conditioned by circulating blood glucose and, therefore, stresses the role of hyperglycaemia in conditioning coagulation abnormalities in diabetes mellitus.

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Section: Discussionmentioning

confidence: 79%

mentioning

confidence: 99%

Blood glucose may condition factor VII levels in diabetic and normal subjects

Ceriello¹,

Giugliano²,

Quatraro

et al. 1988

Diabetologia

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“…43,44 Fibrinogen: Prospective studies in Europe and North America demonstrated that elevated plasma fibrinogen levels are an independent risk factor for CVD, particularly CAD and stroke. 45,46 Fibrinogen levels are positively correlated with age, smoking, body mass, serum insulin levels and, LDL cholesterol, and negatively correlated with alcohol intake, physical activity, HDL cholesterol and female sex hormone use. 47 Previous studies have yielded conflicting results about whether or not Africans have higher fibrinogen levels than white people.…”

Section: Trends In Cad Inmentioning

confidence: 99%

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Akinboboye

Idris²,

Akinkugbe

2003

J Hum Hypertens

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It has been suggested that the prevalence of coronary artery disease (CAD) is steadily increasing in subSaharan Africa. To address this issue, we conducted a Medline search of English language articles on cardiovascular diseasesFand specifically CAD in AfricaF from 1966 to 1997. The prevalence of CAD and related complications is relatively low in most regions in Africa compared to that obtained in the economically developed countries, although the situation is rapidly changing due to trends in urbanization, changes in lifestyle, acquisition of technology and the increasing numbers of tertiary care institutions. There are variations in reported prevalence rates within the different regions, but there is an upward trend in all the regions of the sub-Saharan Africa. This trend is believed to be related to the increasing frequencies of CAD risk factors in the subcontinent.

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“…[8][9][10][11][12] Infusion of AII has been shown to increase circulating plasminogen activator inhibitor-1 (PAI-1) antigen levels in humans, 13 suggesting that increased levels of AII could reduce fibrinolytic capacity. However, data regarding the effect of angiotensinconverting enzyme (ACE) inhibition and AII receptor blockade on fibrinolytic parameters are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis

et al. 2002

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Hypertension is associated with impaired fibrinolysis. Both angiotensin receptor blockers (ARB) and the DASH (Dietary Approaches to Stop Hypertension) diet effectively lower blood pressure in hypertensive patients. Some evidence suggests that treatment with ARBs could increase fibrinolysis, however, data is conflicting. The impact of the DASH diet on fibrinolytic parameters is not known. Fifty-five hypertensive participants (35 African-American, 20 white) were randomly assigned to receive 8 weeks of either a control diet or the DASH diet. The diets did not differ in sodium content (approximately 3 g/day). Within each diet, individuals were randomly assigned to receive losartan or placebo for 4 weeks in double-blind, cross-over fashion. Tissue plasminogen activator (t-PA) antigen, t-PA activity, plasminogen activator inhibitor-1 (PAI-1) activity and plasma renin activity (PRA) were measured at the end of a 2-

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Hæmostatic Function and Cardiovascular Death: Early Results of a Prospective Study

Cited by 696 publications

References 16 publications

Blood glucose may condition factor VII levels in diabetic and normal subjects

Blood glucose may condition factor VII levels in diabetic and normal subjects

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis

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