Haemostatic factors in women with history of Preeclampsia

Portelinha, Ana; Cerdeira, Ana Sofia; Belo, Luı́s; Braga, Jorge; Tejera, Eduardo; Pinto, A. C. S.; Pinto, Fátima; Areias, Maria José; Patrı́cio, Belmiro; Rebelo, Irene

doi:10.1016/j.thromres.2008.10.005

Cited by 16 publications

(12 citation statements)

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“…Women with previous history of PE or even pregnancy hypertension present an increased risk of future development of cardiovascular disease or hypertension [29-31]. This is clearly expressed in our results (Table 2).…”

Section: Discussionsupporting

confidence: 69%

Preeclampsia: a bioinformatics approach through protein-protein interaction networks analysis

2012

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BackgroundIn this study we explored preeclampsia through a bioinformatics approach. We create a comprehensive genes/proteins dataset by the analysis of both public proteomic data and text mining of public scientific literature. From this dataset the associated protein-protein interaction network has been obtained. Several indexes of centrality have been explored for hubs detection as well as the enrichment statistical analysis of metabolic pathway and disease.ResultsWe confirmed the well known relationship between preeclampsia and cardiovascular diseases but also identified statistically significant relationships with respect to cancer and aging. Moreover, significant metabolic pathways such as apoptosis, cancer and cytokine-cytokine receptor interaction have also been identified by enrichment analysis. We obtained FLT1, VEGFA, FN1, F2 and PGF genes with the highest scores by hubs analysis; however, we also found other genes as PDIA3, LYN, SH2B2 and NDRG1 with high scores.ConclusionsThe applied methodology not only led to the identification of well known genes related to preeclampsia but also to propose new candidates poorly explored or completely unknown in the pathogenesis of preeclampsia, which eventually need to be validated experimentally. Moreover, new possible connections were detected between preeclampsia and other diseases that could open new areas of research. More must be done in this area to resolve the identification of unknown interactions of proteins/genes and also for a better integration of metabolic pathways and diseases.

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Section: Discussionsupporting

confidence: 69%

Preeclampsia: a bioinformatics approach through protein-protein interaction networks analysis

2012

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“…D2 testing is important in predicting thromboembolic disease and pregnancy complications, and as a guide for anticoagulant therapy [21]. Both domestically and internationally, many reports have demonstrated that D2 is increased in venous thromboembolism, pulmonary embolism, preeclampsia, and preterm delivery [22][23][24][25] In our research, the D2 level is dramatically higher during early pregnancy, which is in agreement with other studies [26,27]. Although D2 is increased, evidence to verify that the healthy pregnant women were in a DIC hyperfibrinolytic state was not found; normal pregnancy is a compensatory stage of intravascular coagulation.…”

Section: Discussionmentioning

confidence: 99%

Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy

et al. 2011

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“…The pathogenesis of several pregnancy complications is related to thrombosis, such as preeclampsia (PE) (6,7). PE is characterized by a maternal hypercoagulable state with intravascular coagulation, microthrombosis in several organs, and impairment of the uteroplacental circulation (8). In 40% to 72% of preeclamptic women, the presence of at least one thrombophilic factor after delivery has been reported (9)(10)(11).…”

Section: Impact Statementmentioning

confidence: 99%

Thrombophilia: Women-Specific Reference Ranges Can Prevent Misdiagnosis in Women

Veen

Durian

Kruip

et al. 2018

The Journal of Applied Laboratory Medicine

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Background: Thrombophilia is a state where abnormalities of the hemostatic system predispose a patient to thrombosis. Some coagulation factors are generally lower in women than in men. Therefore, the use of routine reference ranges (RRRs) based on male or mixed-sex groups may be misleading in the diagnosis of thrombophilia in women. We hypothesize that this affects the analysis of thrombophilia after pregnancy complications. Therefore, the aim of our study was to investigate the effect of women-specific reference ranges (WRRs) on the interpretation of hemostatic variables in postpartum women. Methods: Coagulant and anticoagulant variables were measured 3 months postpartum in 61 healthy women with an uncomplicated pregnancy and in 197 women who experienced preeclampsia (PE). In 55 of the healthy women, these variables were also measured at least 6 months after an uncomplicated pregnancy and used to calculate WRR. Results: In total, 48% of healthy women had normal results when using routine reference ranges compared with 89% when using WRRs (P < 0.05). In the women with PE, there were normal results in 26% of women when using routine reference ranges compared with 66% when using WRRs (P < 0.05). Conclusion: When using WRRs, fewer abnormalities were seen in healthy women as well as in women with a history of PE, which may prevent misdiagnosis of thrombophilia.

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Haemostatic factors in women with history of Preeclampsia

Cited by 16 publications

References 40 publications

Preeclampsia: a bioinformatics approach through protein-protein interaction networks analysis

Preeclampsia: a bioinformatics approach through protein-protein interaction networks analysis

Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy

Thrombophilia: Women-Specific Reference Ranges Can Prevent Misdiagnosis in Women

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