Haemostatic and fibrinolytic factors in men with a small abdominal aortic aneurysm

Abstract

: Fibrin turnover was increased in these men with a small AAA, independently of concomitant CVD, conventional risk factors and inflammatory markers. Enhanced fibrin turnover may contribute to the risk of cardiac complications in this group.

Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm

“…14 Only three studies have analyzed both tPA antigen and PAI-1 activity levels, and all three studies report no significant difference compared to their control populations. 47,50,51 Adam et al 43 are the only group to report tPA activity and PAI-1 activity levels which were comparable to the manufacturer's normal reference range in patients with symptomatic, non-ruptured AAAs.…”

“…[29][30][31] An association between elevated fibrinogen and atherosclerotic peripheral arterial disease has been widely reported, and elevated levels of plasma fibrinogen are found in patients who subsequently develop peripheral arterial disease. 30,[32][33][34] The association between intact AAAs and plasma fibrinogen levels has been extensively investigated 8,[35][36][37][38][39][40][41][42][43][44][45][46][47] (Table I). Seven of 14 studies have reported significantly elevated fibrinogen levels in patients with asymptomatic AAAs.…”

“…All studies report elevated levels of plasma D-dimer in patients with AAAs. On multivariate analysis, both Lee et al 44 and Parry et al 47 reported an independent association between circulating D-dimer levels and AAAs.…”

“…Six studies have reported the effect of AAAs on both D-dimer levels and tPA and/or PAI-1. 35,43,44,47,50,51 The majority of studies report no difference in circulating tPA antigen levels in patients with and without an AAA. The one exception is Wanhainen et al 53 who report elevated levels of tPA antigen in patients with screen-detected AAAs.…”

Perioperative assessment of changes in tissue factor and its inhibitor in patients with abdominal aortic aneurysm treated using classical and intravascular methods

“…Inflammatory factors and progressive degradation of the extracellular matrix damage the endothelium, triggering the coagulation cascade. Such hemostatic disturbances are one of the main characteristics of AAA frequently leading to perioperative complications [4]. The coagulation cascade is activated by TF, a 47 kDa trans membrane protein receptor for Factor VII/VIIa, constitutively expressed in cells surrounding blood vessels and certain tissues, such as heart, brain and lungs.…”