Haemostatic agents in apical surgery. A systematic review

Clé-Ovejero, Adrià; Valmaseda‐Castellón, Eduard

doi:10.4317/medoral.21109

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…The insertion of sponges made of gelatin is considered the gold standard treatment. The structure of the sponge provides mechanical stability to the coagulum, and the hemostatic effect of collagen inserts comprises the activation of the intrinsic coagulation pathway and aggregation of platelets upon contact with collagen [45]. Histological cross-sectional images showed correspondingly stable thrombus formations in extraction sockets, which were treated with GSP 5 days after surgery.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Hemostatic Effect of an Innovative Tissue Adhesive during Extraction Therapy under Rivaroxaban in a Rodent Model

Heitzer

Winnand

Ooms

et al. 2023

JFB

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An increase in rivaroxaban therapies is associated with increased numbers of postoperative bleeding despite the use of hemostatic sponges, which are currently the gold standard treatment. VIVO has shown promising hemostatic results, favorable tissue properties, and ease of application, although it has not yet been used in the oral cavity. The aim of this study was to evaluate the hemostatic properties of VIVO in the extraction sockets of 31 rodents and compare this to gelatin sponge (GSP) therapy. At rivaroxaban concentrations of 264.10 ± 250.10 ng/mL, 62 extraction sockets were generated, of which 31 were treated with VIVO and 31 with GSP. The duration time, early and late bleeding events, and wound healing score were determined. Histologic examinations of the tissues were performed after 5 days. VIVO presented a longer procedure, 1.26 ± 0.06 min, but a significantly shorter bleeding time, 0.14 ± 0.03 min. There was no difference between the two groups in terms of the severity and timing of bleeding. More minor early bleeding events were observed for GSP. VIVO showed a significantly better healing score, with favorable histological results. In an animal study, VIVO showed promising hemostatic properties after tooth extraction under ongoing anticoagulative therapy.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Hemostatic Effect of an Innovative Tissue Adhesive during Extraction Therapy under Rivaroxaban in a Rodent Model

Heitzer

Winnand

Ooms

et al. 2023

JFB

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“…Agents that are locally used for this purpose have been reported and include chitosan linear polymer (Celox®), poly-N-acetylglucosamine (Chitin®), fibrin glues, microporous hydrogel-forming polyacrylamide (BioHemostat®), microporous polysaccharide hemosphere (TraumaDEX®), oxidized cellulose (Bloodcare®), and Ankaferd Blood Stopper® (ABS) [4]. However, inflammation and/or infection risks have also been reported in various studies through the use of most of these materials [5][6][7][8][9], and no consensus on which product is the ideal has been reached. Hence, studies in the literature report a continuous search for an optimal hemostatic agent.…”

Section: Introductionmentioning

confidence: 99%

Effects of Algan hemostatic agent foam in rat femoral artery injury model: A randomized animal trial

et al. 2022

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Background/Aim: Nowadays, many deaths are related to vessel injury-induced blood loss. Failure to control bleeding also increases the risk of death. This study aimed to investigate the hemostatic effects of the Algan Hemostatic Agent (AHA) foam application in a rat model in which severe femoral artery bleeding was induced. Methods: Fourteen rats were randomly assigned to two groups: (1) control (physiological saline) (n = 7) and (2) AHA foam (n = 7). The left femoral artery of the rats was incised and when the bleeding started, and the area was pressed with another sponge for 10 s in all rats. Afterwards, physiological saline solution impregnated gauze or AHA foam was placed over same area. A chronometer was started and area was checked after 2 min. If no bleeding occurred during the first 2 min of application, it was recorded as “successful”. If bleeding occurred, the same procedure was repeated up to three times. If hemostasis could not be achieved even after the third application, it was considered a failure, and “failed” was recorded. All animals were sacrificed under high anesthesia for least 10 min after the experiment. Results: Application of AHA resulted in complete (100%) control of bleeding in all rats within the first 2 min. In control group, hemostasis was achieved in 1 out of 7 (14.3%) rats by the third application. Failure was recorded for the remaining six rats. The hemostatic success rate of the AHA foam was significantly higher than the rates of control group (P = 0.005). Conclusion: AHA foam is a very effective hemostatic agent and can be applied easily on vascular trauma models. Further studies are needed to elucidate hemostatic features of AHA.

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“…,47 Quality of evidence: Moderate ⊕⊕⊕⊝ IDENTIFICATION OF BARRIERS: In Colombia, the use of laser is still limited. To date, not enough evidence is reported 3 to indicate the use of laser therapies in EM.…”

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confidence: 99%

Guía De Práctica Clínica Para El Manejo Quirúrgico en Endodoncia De La Enfermedad Periapical Postratamiento

Guerrero

Rodriguez

Serrano

2019

Rev Fac Odontol Univ Antioq

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Introduction: in Colombia, persisting post-endodontic disease has been reported by up to 45%, validating the use of secondary alternative therapies, like endodontic microsurgery (EM). The aim of this study was to systematically—and with reliable scientific evidence—develop de Novo Clinical Practice Guidelines for the surgical endodontic management of post-treatment periapical disease (PPD), with more accurate recommendations for therapeutic decisions and preferences consulted with both practitioners and patients. Method: the guidelines developers team identified EM as a topic in the literature and established the scope, objective, questions, and outcomes, which were analyzed using the scientific evidence reported in secondary or primary clinical studies. A first screening identified titles and abstracts for each question asked. The validity of the selected studies was quantified with tools like AMSTAR or SIGN. Finally, the strength of recommendations and the quality of evidence were confirmed with GRADE. Results: concepts like PPD, EM indication, use of local anesthetics, antibiotics and presurgical anti-inflammatory drugs, effect of magnification, implementation of cone beam computed tomography, hemostasis, retrograde filling, and control time were integrated, supporting each topic with relevant evidence, experts’ recommendations, and even good practice points. Conclusions: this document is considered a tool with sufficient evidence for clinical decision-making in EM.

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Haemostatic agents in apical surgery. A systematic review

Cited by 4 publications

References 24 publications

Evaluation of the Hemostatic Effect of an Innovative Tissue Adhesive during Extraction Therapy under Rivaroxaban in a Rodent Model

Evaluation of the Hemostatic Effect of an Innovative Tissue Adhesive during Extraction Therapy under Rivaroxaban in a Rodent Model

Effects of Algan hemostatic agent foam in rat femoral artery injury model: A randomized animal trial

Guía De Práctica Clínica Para El Manejo Quirúrgico en Endodoncia De La Enfermedad Periapical Postratamiento

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